1|Page
NR546 MID-TERM EXAM NEWEST 2025 ACTUAL EXAM TEST
BANK| ADVANCED PHARMACOLOGY
PSYCHOPHARMACOLOGY FOR THE PMHNP MID-TERM
EXAM WITH COMPLETE 350 REAL EXAM QUESTIONS AND
CORRECT VERIFIED ANSWERS/ ALREADY GRADED A+
(MOST RECENT!!)
Which medication is least associated with weight gain? - ANSWER -
aripiprazole
Which dopamine pathway is associated with positive symptoms of
schizophrenia? - ANSWER - mesolimbic pathway
Which pathway is associated with negative symptoms? - ANSWER -
The mesocortical pathway
Is part of the extrapyramidal nervous system and associated with
extrapyramidal symptoms (EPS) - ANSWER - nigrostriatal pathway
This pathway is associated with hyperprolactinemia. - ANSWER - The
tuberoinfundibular pathway
A 34-year old male recently began experiencing breast secretions while
receiving risperidone . Which dopamine pathway is associated with this
side effect? - ANSWER - tuberoinfundibular pathway
pg. 1
,2|Page
A 44-year-old woman is initiated on an atypical antipsychotic for the
treatment of schizophrenia. Regarding affinity, atypical antipsychotics
demonstrate which of the following most often? - ANSWER - Atypical
antipsychotics have equal positive symptom antipsychotic actions and
low extrapyramidal symptoms.
What medication has the highest risk for galactorrhea, due to
hyperprolactinemia. - ANSWER - risperidone
Include other symptoms such as disorganized speech, disorganized
behavior, gross distortions of reality testing, and as diminished
emotional expression and decreased motivation. - ANSWER - Negative
symptoms
If the functioning of this pathway is disrupted by lesions or drugs,
prolactin levels can also rise. Elevated prolactin levels are associated
with galactorrhea (breast secretions), gynecomastia (enlarged breasts
especially in men), amenorrhea (loss of ovulation and menstrual
periods), and possibly other problems such as sexual dysfunction. -
ANSWER - tuberoinfundibular DA neurons
Projects from the midbrain VTA but sends its axons to areas of the
prefrontal cortex, where they may have a role in mediating cognitive
symptoms (dorsolateral prefrontal cortex or DLPFC) and affective
symptoms (ventromedial prefrontal cortex or VMPFC) of schizophrenia.
- ANSWER - The mesocortical dopamine pathway
pg. 2
,3|Page
which projects from the substantia nigra to the basal ganglia or striatum,
is part of the extrapyramidal nervous system and controls motor function
and movement. - ANSWER - Nigrostriatal dopamine pathway
projects from the midbrain ventral tegmental area (VTA) to the nucleus
accumbens, a part of the limbic system of the brain thought to be
involved in many behaviors such as pleasurable sensations,the powerful
euphoria of drugs of abuse, and delusions and hallucinations of
psychosis. - ANSWER - mesolimbic dopamine pathway
What are the three major hypotheses of pychosis? - ANSWER - The
Dopamine theory, the Glutamate theory, and the serotonin theory.
is a syndrome that can be associated with several different psychiatric
disorders. Symptoms include hallucinations, delusions, disorganized
speech, disorganized behavior, and distortions of reality. This syndrome
can affect a person's cognition, affective response, communication,
capacity to recognize reality, and ability to relate to others. - ANSWER -
psychosis
What diagnosis has a diagnosis of psychosis as a feature? - ANSWER -
mania
depression
cognitive disorders
dementia
pg. 3
, 4|Page
What are some positive symptoms? - ANSWER - Hallucinations
Delusions
Thought disorder
Hostility
Excitability
What are some Negative symptoms? - ANSWER - Affective flattening
Alogia
Anhedonia
Amotivation
Asociality
What area of the brain is associated with negative and affective
symptoms? - ANSWER - Mesocortical and ventromedial prefrontal
cortex:
What area of the brain is associated with cognitive symptoms? -
ANSWER - Dorsolateral
What area of the brain is associated with aggressive, impulsive
symptoms? - ANSWER - Orbitofrontal and connections to the amygdala
pg. 4
NR546 MID-TERM EXAM NEWEST 2025 ACTUAL EXAM TEST
BANK| ADVANCED PHARMACOLOGY
PSYCHOPHARMACOLOGY FOR THE PMHNP MID-TERM
EXAM WITH COMPLETE 350 REAL EXAM QUESTIONS AND
CORRECT VERIFIED ANSWERS/ ALREADY GRADED A+
(MOST RECENT!!)
Which medication is least associated with weight gain? - ANSWER -
aripiprazole
Which dopamine pathway is associated with positive symptoms of
schizophrenia? - ANSWER - mesolimbic pathway
Which pathway is associated with negative symptoms? - ANSWER -
The mesocortical pathway
Is part of the extrapyramidal nervous system and associated with
extrapyramidal symptoms (EPS) - ANSWER - nigrostriatal pathway
This pathway is associated with hyperprolactinemia. - ANSWER - The
tuberoinfundibular pathway
A 34-year old male recently began experiencing breast secretions while
receiving risperidone . Which dopamine pathway is associated with this
side effect? - ANSWER - tuberoinfundibular pathway
pg. 1
,2|Page
A 44-year-old woman is initiated on an atypical antipsychotic for the
treatment of schizophrenia. Regarding affinity, atypical antipsychotics
demonstrate which of the following most often? - ANSWER - Atypical
antipsychotics have equal positive symptom antipsychotic actions and
low extrapyramidal symptoms.
What medication has the highest risk for galactorrhea, due to
hyperprolactinemia. - ANSWER - risperidone
Include other symptoms such as disorganized speech, disorganized
behavior, gross distortions of reality testing, and as diminished
emotional expression and decreased motivation. - ANSWER - Negative
symptoms
If the functioning of this pathway is disrupted by lesions or drugs,
prolactin levels can also rise. Elevated prolactin levels are associated
with galactorrhea (breast secretions), gynecomastia (enlarged breasts
especially in men), amenorrhea (loss of ovulation and menstrual
periods), and possibly other problems such as sexual dysfunction. -
ANSWER - tuberoinfundibular DA neurons
Projects from the midbrain VTA but sends its axons to areas of the
prefrontal cortex, where they may have a role in mediating cognitive
symptoms (dorsolateral prefrontal cortex or DLPFC) and affective
symptoms (ventromedial prefrontal cortex or VMPFC) of schizophrenia.
- ANSWER - The mesocortical dopamine pathway
pg. 2
,3|Page
which projects from the substantia nigra to the basal ganglia or striatum,
is part of the extrapyramidal nervous system and controls motor function
and movement. - ANSWER - Nigrostriatal dopamine pathway
projects from the midbrain ventral tegmental area (VTA) to the nucleus
accumbens, a part of the limbic system of the brain thought to be
involved in many behaviors such as pleasurable sensations,the powerful
euphoria of drugs of abuse, and delusions and hallucinations of
psychosis. - ANSWER - mesolimbic dopamine pathway
What are the three major hypotheses of pychosis? - ANSWER - The
Dopamine theory, the Glutamate theory, and the serotonin theory.
is a syndrome that can be associated with several different psychiatric
disorders. Symptoms include hallucinations, delusions, disorganized
speech, disorganized behavior, and distortions of reality. This syndrome
can affect a person's cognition, affective response, communication,
capacity to recognize reality, and ability to relate to others. - ANSWER -
psychosis
What diagnosis has a diagnosis of psychosis as a feature? - ANSWER -
mania
depression
cognitive disorders
dementia
pg. 3
, 4|Page
What are some positive symptoms? - ANSWER - Hallucinations
Delusions
Thought disorder
Hostility
Excitability
What are some Negative symptoms? - ANSWER - Affective flattening
Alogia
Anhedonia
Amotivation
Asociality
What area of the brain is associated with negative and affective
symptoms? - ANSWER - Mesocortical and ventromedial prefrontal
cortex:
What area of the brain is associated with cognitive symptoms? -
ANSWER - Dorsolateral
What area of the brain is associated with aggressive, impulsive
symptoms? - ANSWER - Orbitofrontal and connections to the amygdala
pg. 4
