Endo shorts
1. loop vs thiazides on Ca: loop-ca excretion
thiazide-Ca retension
2. high Ph effect on Ca: low Ca-more Ca bind to albumin
3. alpha and beta R stimulation on insulin secretion
M3: A2-inhbit(think glucagon from alph cells)
B2-increase(think beta cell secret insulin)
M3-stimulate(PSNS-eat realx)
4. Juxta glomerular cell site
macula densa site
function: juxta glomerular cell-afferent-serete renin
macula densa-DCT-sense low Nacl
5. Serum Osmolality (normal range): 275-295 mOsm/kg
,6. SIADH volume status: euvolemia
7. Tolvapton ,conivapton class,use: ADH antagonists
use in SIADH
8. SIADH treatment
-drug 3
-iv fluid
-fluid intake: Fluid restriction,
IV hypertonic saline,
conivaptan/tolvaptan,
demeclocycline
9. diabetes insipidus treatment
-drug central,nephrogenic
-diuretic-not logical MOA
,-fluid intake: Desmopressin (central);
hydrochlorothiazide,
indomethacin,
amiloride (nephrogenic)
give fluid
10. acromegaly test: OGTT-glucose supresses GH normally
, 11. Lugols iodine/KI2 use,MOA: inhibit syntheisis of T4,T3(by inhibiting I entry in to cell)
reduce vascularity of gland
given before thyroidectomy
after radiation exposure
12. propylthiouracil
-action
-use: inhibit 5-dioidenase(T4>T3)
preganancy
(PPP-5penta,preganacy,PTU)
13. prednisolone
use on Graves: to redcue ophthalmopathy
-reduce autoimmune effect
-reduce T4>T3 conversion
14. drug for thyroid storm 4: PTU,propranolol,prednisoslone,potassium iodide
15. psammoma bodies: meningioma
1. loop vs thiazides on Ca: loop-ca excretion
thiazide-Ca retension
2. high Ph effect on Ca: low Ca-more Ca bind to albumin
3. alpha and beta R stimulation on insulin secretion
M3: A2-inhbit(think glucagon from alph cells)
B2-increase(think beta cell secret insulin)
M3-stimulate(PSNS-eat realx)
4. Juxta glomerular cell site
macula densa site
function: juxta glomerular cell-afferent-serete renin
macula densa-DCT-sense low Nacl
5. Serum Osmolality (normal range): 275-295 mOsm/kg
,6. SIADH volume status: euvolemia
7. Tolvapton ,conivapton class,use: ADH antagonists
use in SIADH
8. SIADH treatment
-drug 3
-iv fluid
-fluid intake: Fluid restriction,
IV hypertonic saline,
conivaptan/tolvaptan,
demeclocycline
9. diabetes insipidus treatment
-drug central,nephrogenic
-diuretic-not logical MOA
,-fluid intake: Desmopressin (central);
hydrochlorothiazide,
indomethacin,
amiloride (nephrogenic)
give fluid
10. acromegaly test: OGTT-glucose supresses GH normally
, 11. Lugols iodine/KI2 use,MOA: inhibit syntheisis of T4,T3(by inhibiting I entry in to cell)
reduce vascularity of gland
given before thyroidectomy
after radiation exposure
12. propylthiouracil
-action
-use: inhibit 5-dioidenase(T4>T3)
preganancy
(PPP-5penta,preganacy,PTU)
13. prednisolone
use on Graves: to redcue ophthalmopathy
-reduce autoimmune effect
-reduce T4>T3 conversion
14. drug for thyroid storm 4: PTU,propranolol,prednisoslone,potassium iodide
15. psammoma bodies: meningioma
