GMS 6552 Exam 2026 Questions and
Answers
Which type of receptor most often utilizes second-messenger systems in its
signaling? - Correct answer-G-protein coupled receptors
Assume you have receptor antagonists that are able to stop receptor signaling
immediately. For which type of receptor would it take the longestto see the effects
of your drug at the cellular level? - Correct answer-Nuclear receptors
For which type of receptor would having adequate membrane permeability of an
agonist be most critical? - Correct answer-Nuclear receptors
Is it more likely for a G-protein coupled receptor agonist to bind near the N- or C-
terminus of the receptor? - Correct answer-N-terminus
Is it more likely to find a GPCR bound to a G-protein that is also bound to GTP or
GDP? - Correct answer-GDP
Which protein ultimately is translocated from the cytoplasm to the nucleus as a
result of JAK signaling? - Correct answer-STAT
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, Where, in relation to the protein-coding region of a gene, are the binding sites that
become occupied by nuclear receptors? - Correct answer-Upstream
The levels of which second-messenger would be expected to increase following
administration of nitroglycerin? - Correct answer-cGMP
Does TGF-β treatment cause cells to grow more or less in the soft-agar assay? -
Correct answer-More
The latent TBF-β peptide must be cleaved by what protease in order to be
activated? - Correct answer-Plasmin
In the TGF-β pathway, which protein becomes activated first upon binding of a
ligand? - Correct answer-TGFβR2
How many DNA binding domains do Smads have? - Correct answer-1
Different Smad complexes bind different genes. Which group of Smads is
responsible for this specificity? - Correct answer-R-Smads
Would it likely be most beneficial (for the tumor) for an early tumor to up- or
down-regulate the TGF-β pathway? - Correct answer-Down-regulate
Would it likely be most beneficial (for the tumor) for a large, well-developed tumor
to up- or down-regulate the TGF-β pathway? - Correct answer-Up-regulate
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Answers
Which type of receptor most often utilizes second-messenger systems in its
signaling? - Correct answer-G-protein coupled receptors
Assume you have receptor antagonists that are able to stop receptor signaling
immediately. For which type of receptor would it take the longestto see the effects
of your drug at the cellular level? - Correct answer-Nuclear receptors
For which type of receptor would having adequate membrane permeability of an
agonist be most critical? - Correct answer-Nuclear receptors
Is it more likely for a G-protein coupled receptor agonist to bind near the N- or C-
terminus of the receptor? - Correct answer-N-terminus
Is it more likely to find a GPCR bound to a G-protein that is also bound to GTP or
GDP? - Correct answer-GDP
Which protein ultimately is translocated from the cytoplasm to the nucleus as a
result of JAK signaling? - Correct answer-STAT
©COPYRIGHT 2025, ALL RIGHTS RESERVED 1
, Where, in relation to the protein-coding region of a gene, are the binding sites that
become occupied by nuclear receptors? - Correct answer-Upstream
The levels of which second-messenger would be expected to increase following
administration of nitroglycerin? - Correct answer-cGMP
Does TGF-β treatment cause cells to grow more or less in the soft-agar assay? -
Correct answer-More
The latent TBF-β peptide must be cleaved by what protease in order to be
activated? - Correct answer-Plasmin
In the TGF-β pathway, which protein becomes activated first upon binding of a
ligand? - Correct answer-TGFβR2
How many DNA binding domains do Smads have? - Correct answer-1
Different Smad complexes bind different genes. Which group of Smads is
responsible for this specificity? - Correct answer-R-Smads
Would it likely be most beneficial (for the tumor) for an early tumor to up- or
down-regulate the TGF-β pathway? - Correct answer-Down-regulate
Would it likely be most beneficial (for the tumor) for a large, well-developed tumor
to up- or down-regulate the TGF-β pathway? - Correct answer-Up-regulate
©COPYRIGHT 2025, ALL RIGHTS RESERVED 2
