UWSA1 EXAM – Questions With Fully Explained
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Terms in this set (108)
diabetic nephropathy
Kimmelstiel-Wilson nodules
complication of Paget's Osteosarcoma , excessive blood flow : high output
disease heart failure and vascular steal and fracture
destruction of the normal trabecular bone pattern ,
mixed radiosense (sclerotic) and radiolucent (lytic)
Describe osteosarcoma
areas, and periosteal new bone formation with lifting of
the periosteum .
Radiographic finding of crescent sign ( subchondral collapse at the femoral
avascular necrosis head)
Sensitive indicator of DNA laddering: DNA fragments in multiples of 180 base
apoptosis pairs .
evade programmed cell death , via overexpression of
A hallmark of cancer cells BCL2 , an antiapoptotic protein. In fact, most follicular B
is their ability to .... cell lymphomas are associated with a T ( 14,18), that
leads to BCL2 overexpression
Mechanism of action of Aumenta ACH - anticholinesterase - Cholinomimetic
physostigmine agent -
Muscarinic effects (DUMBBELS), Nicotinic effecrs
Cholinomimetic effects
(neuromusc blockade)
antidote for Physostigmine
anticholinergics
Antidote for cholinergic atropine (anti-cholinergic drug)
poisoning
,Bronchoconstriction (M3) is Cholinergic agents - treat with muscarinic antagonist
an effect of ?
Atropine . Although cocaine
Confusion , agitation , bugs
toxicity can also be characterized
crawling on his skin ,
by tactile hallucinations pt has to
blurred vision , mucus
be diaphoretic ( not dry) and also
membranes are dry and
usually they will have tachycardia
skin is warm and flushed .
, htn, vasoconstriction resulting in
Overdose of?
chest pain
Both offspring were found Germline mosaicism
to be heterozygous for the
same mutation. How
unaffected couple having
children with disorder?
Occurrence of multiple, seemingly unrelated
Pleiotropy phenotypic manifestation, often in different organ
systems, as a result of a single genetic defect
Not all individuals with a mutant genotype show the
incomplete penetrance
mutant phenotype
t (15;17).
29 yo , fatigue , fever and
Auer rods are primary granules found in myeloblasts
sore throat . Auer rods.
and promyelocytes - found in Acute Myeloid Leukemia (
What is the chromosomal
AML) - Particularly acute promyelocytic leukemia (APL)
abnormalities
.
T (8;14)
Burkitt lymphoma
translocation
T (9;22) Leukocytosis with many
CML (chronic myelogenous immature myeloid cells
leukemia) translocation
T (12;21)
acute lymphocytic Anemia , thrombocytopenia and
leukemia lymphoblasts.
, T (14;18) FOURlicular (4 , 8)
Follicular lymphoma Malignant cells with notches or
translocation clefts.
IL-2 (Stimulate the growth and
which cytokine is produced
differentiation of T cells , B cells ,
exclusively by lymphocytes
NK cells and macrphages )
?
Intercellular adhesions Cadherins.
between epithelial cells are They are adhesion molecules that bind epithelial cells
disruped but the cell together. Interactions between the extracellular
adhesions to the basement domains of adjacent cadherins are calcium-dependent ,
m. remain intact. The same removing calcium from the extracel fluid will cause
effect happens in an dissociation of cadherin-mediated junctions , leading to
depleted of calcium ions. loss of cell-cell adhesion
What is the molecule
affected ?
Action of Cell adhesin to the basement membrane
hemidesmosomes
Low pH of duodenal content.
which trigger copious The delivery of acid to the duodenum triggers
bicarbonate-rich fluid gallbladder bile release and stimulates S cells to
accumulation in teh release secretin. Secretin (+) bicarbonate-rich fluid , to
duodenum? establish a neutral pH in the duodenal lumen.and allows
enzymes to function properly.
What is the immediate transient dimerization
effect of ligand binding to
tyrosine kinase r?
Heminefrectomy . How is 80%
the GFR six weeks after
surgery ?
Increase cGMP in the smooth
Inhibition of isoenzyme
muscle that surround the
phosphodiesterase 5 acts
cavernous venous sinuses of the
where ?
corpora cavernosa ( area B)
Solutions
Save
Terms in this set (108)
diabetic nephropathy
Kimmelstiel-Wilson nodules
complication of Paget's Osteosarcoma , excessive blood flow : high output
disease heart failure and vascular steal and fracture
destruction of the normal trabecular bone pattern ,
mixed radiosense (sclerotic) and radiolucent (lytic)
Describe osteosarcoma
areas, and periosteal new bone formation with lifting of
the periosteum .
Radiographic finding of crescent sign ( subchondral collapse at the femoral
avascular necrosis head)
Sensitive indicator of DNA laddering: DNA fragments in multiples of 180 base
apoptosis pairs .
evade programmed cell death , via overexpression of
A hallmark of cancer cells BCL2 , an antiapoptotic protein. In fact, most follicular B
is their ability to .... cell lymphomas are associated with a T ( 14,18), that
leads to BCL2 overexpression
Mechanism of action of Aumenta ACH - anticholinesterase - Cholinomimetic
physostigmine agent -
Muscarinic effects (DUMBBELS), Nicotinic effecrs
Cholinomimetic effects
(neuromusc blockade)
antidote for Physostigmine
anticholinergics
Antidote for cholinergic atropine (anti-cholinergic drug)
poisoning
,Bronchoconstriction (M3) is Cholinergic agents - treat with muscarinic antagonist
an effect of ?
Atropine . Although cocaine
Confusion , agitation , bugs
toxicity can also be characterized
crawling on his skin ,
by tactile hallucinations pt has to
blurred vision , mucus
be diaphoretic ( not dry) and also
membranes are dry and
usually they will have tachycardia
skin is warm and flushed .
, htn, vasoconstriction resulting in
Overdose of?
chest pain
Both offspring were found Germline mosaicism
to be heterozygous for the
same mutation. How
unaffected couple having
children with disorder?
Occurrence of multiple, seemingly unrelated
Pleiotropy phenotypic manifestation, often in different organ
systems, as a result of a single genetic defect
Not all individuals with a mutant genotype show the
incomplete penetrance
mutant phenotype
t (15;17).
29 yo , fatigue , fever and
Auer rods are primary granules found in myeloblasts
sore throat . Auer rods.
and promyelocytes - found in Acute Myeloid Leukemia (
What is the chromosomal
AML) - Particularly acute promyelocytic leukemia (APL)
abnormalities
.
T (8;14)
Burkitt lymphoma
translocation
T (9;22) Leukocytosis with many
CML (chronic myelogenous immature myeloid cells
leukemia) translocation
T (12;21)
acute lymphocytic Anemia , thrombocytopenia and
leukemia lymphoblasts.
, T (14;18) FOURlicular (4 , 8)
Follicular lymphoma Malignant cells with notches or
translocation clefts.
IL-2 (Stimulate the growth and
which cytokine is produced
differentiation of T cells , B cells ,
exclusively by lymphocytes
NK cells and macrphages )
?
Intercellular adhesions Cadherins.
between epithelial cells are They are adhesion molecules that bind epithelial cells
disruped but the cell together. Interactions between the extracellular
adhesions to the basement domains of adjacent cadherins are calcium-dependent ,
m. remain intact. The same removing calcium from the extracel fluid will cause
effect happens in an dissociation of cadherin-mediated junctions , leading to
depleted of calcium ions. loss of cell-cell adhesion
What is the molecule
affected ?
Action of Cell adhesin to the basement membrane
hemidesmosomes
Low pH of duodenal content.
which trigger copious The delivery of acid to the duodenum triggers
bicarbonate-rich fluid gallbladder bile release and stimulates S cells to
accumulation in teh release secretin. Secretin (+) bicarbonate-rich fluid , to
duodenum? establish a neutral pH in the duodenal lumen.and allows
enzymes to function properly.
What is the immediate transient dimerization
effect of ligand binding to
tyrosine kinase r?
Heminefrectomy . How is 80%
the GFR six weeks after
surgery ?
Increase cGMP in the smooth
Inhibition of isoenzyme
muscle that surround the
phosphodiesterase 5 acts
cavernous venous sinuses of the
where ?
corpora cavernosa ( area B)
