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Exam (elaborations)

NCLEX Pharmacology Exam 2025/2026 | 100% Verified Questions and Answers with Detailed Rationales

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Prepare confidently for your NCLEX Pharmacology Exam 2025/2026 with this comprehensive and verified study guide featuring 100% accurate pharmacology questions and answers. This resource covers all key nursing drug categories, including mechanisms of action, adverse effects, contraindications, safe medication administration, and patient education. Perfect for nursing students, NCLEX test-takers, RN, and LPN candidates, this guide strengthens your clinical decision-making and pharmacology mastery through realistic NCLEX-style questions and detailed rationales that ensure exam readiness and confidence.

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1.A provider prescribes phenobarbital for a client who has a seizure disorder. The medication has a long
half-life of 4 days. How many times per day should the nurse expect to administer this medication?



A. One



B. Two



C. Three



D. Four - ANSWER✔✔✨---A. Medications with long half-lives remain at their therapeutic levels
between doses for long periods of time. The nurse should expect to administer this medication once a
day.



A staff educator is reviewing medication dosages and factors that influence medication metabolism with
a group of nurses at an in-service presentation. Which of the following factors should the educator
include as a reason to administer lower medication dosages? (Select all that apply.)



A. Increased renal secretion



B. Increased medication-metabolizing enzymes



C. Liver failure



D. Peripheral vascular disease

,E. Concurrent use of medication the same pathway metabolizes - ANSWER✔✔✨---Answer:



C. Liver failure decreases metabolism and thus increases the concentration of a medication. This
requires decreasing the dosage.



E. When the same pathway metabolizes two medications, they compete for metabolism, thereby
increasing the concentration of one or both medications. This requires decreasing the dosage of one or
both medications.



A nurse is preparing to administer

eye drops to a client. Which of

the following actions should the

nurse take? (Select all that apply.)



A.have the client lie on her side.



B.Ask the client to look

up at the ceiling.



C.Tell the client to blink when the drops enter her eye.



D.Drop the medication

into the center of the

client's conjunctival sac.



E.Instruct the client to close her eye gently after instillation - ANSWER✔✔✨---B. The client should
look upward to

keep the drops from falling onto her cornea.

D. The nurse should drop the medication into the

center of the conjunctival sac to promote distribution.

,E. The client should close her eye gently

to promote distribution of the medication



A nurse is completing discharge teaching for a client who has a new prescription for transdermal
patches. Which of the following

statements should the nurse identify as an indication that the client

understands the instructions?



A."I will clean the site with

an alcohol swab before

I apply the patch."



B."I will rotate the application sites weekly."



C."I will apply the patch to an area of skin with no hair."



D."I will place the new patch on the site of the old patch. - ANSWER✔✔✨---C. The client should
apply the patch to a hairless

area of skin to promote absorption of the medication.



A nurse reviewing a client's

medical record notes a new prescription for verifying the trough

level of the client's medication. Which of the following actions should the nurse take?



A.Obtain a blood specimen

immediately prior to

administering the next

dose of medication.

, B.Verify that the client has

been taking the medication

for 24 hr before obtaining

a blood specimen.



C.Ask the client to pr

ovide a urine specimen after the next dose of medication.



D.Administer the medication,and obtain a blood specimen 30 min late - ANSWER✔✔✨---A. To verify
trough levels of a medication, the

nurse should obtain a blood specimen immediately

before administering the next dose of medication.



A nurse is preparing a client's medications. Which of the following actions should the nurse take in
following legal practice

guidelines? (Select all that apply.)



A.maintain skill competency.



B.Determine the dosage.



C. monitor for adverse effects.



D.Safeguard medications.



E.Identify the client's diagnosis - ANSWER✔✔✨---A.maintaining skill competency and using
appropriate

administration techniques are legal responsibilities of the nurse

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