Pathopharmacological
Foundations Tested Questions
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A 23-year-old woman comes in for prenatal counseling. While completing her
family history, she reports her brother has cystic fibrosis. She does not know if she
is a carrier. She asks if her children will be affected by the disease.
What is an accurate way to determine the likelihood of this patient's children being
affected?
A sweat test
A genetic or a carrier test
A history and a physical
A fertility test - Correct Answer-✔✔A genetic or carrier test
The disease occurs when an individual inherits the mutated gene from each parent.
When only one mutated gene is inherited, the individual is labeled a carrier.
chance of the disease.
A 31-year-old man comes into the office for an exam. He is 6' 5 " with a high-
pitched voice, and he has a moderate degree of mental impairment. It is
discovered upon exam that his body hair is sparse, his testes are small, and he has
gynecomastia.
Which genetic disorder should this patient be tested for?
,Klinefelter syndrome
Turner syndrome
Partial trisomy
Sex chromosome aneuploidy - Correct Answer-✔✔Klinefelter syndrome: a
hereditary disease also known as 47,XXY or XXY that manifests as the series of
symptoms described.
A six-month-old female infant with failure to thrive comes in to the office with her
parents. It is noticed upon exam that the patient has facial deformities and is
jaundiced. A complete blood count (CBC) is ordered, which reveals anemia. When
that patient's blood is examined under a microscope, the red blood cells appear
small and abnormally shaped. A mutational analysis is ordered, and alpha
thalassemia is diagnosed.
What is the likelihood of incidence of these parent's future children having alpha
thalassemia?
25%
100%
0%
50% - Correct Answer-✔✔25% or 1/4 chance
A 64-year-old male truck driver comes in complaining of pain in his lower left calf.
He states he drives eight to ten hours per day. Upon exam, swelling and mottled
coloring are noted in the patient's calf. A D-dimer test is ordered and comes back
positive.
,Which additional test should be ordered to confirm a diagnosis in this patient?
A CT scan
A Doppler Ultrasound
The D-dimer test again
A clotting factors test - Correct Answer-✔✔A Doppler Ultrasound is the initial test of
choice for patients who are not initially stratified according to clinical pretest
probability (PTP) as being low, moderate, or high risk for DVT.
A 54-year-old man comes into a clinic for a routine visit. His initial BP is 148/92.
After a recheck 15 minutes later, his BP is 140/90. He states he suffers from "white
coat hypertension." He states he has no history of high blood pressure and no
family history of high blood pressure.
Which nursing intervention would assist this patient in receiving a clinical diagnosis
of hypertension?
Ordering the patient a cholesterol level test
Checking the patient's blood pressure in three months
Completing a biochemical blood profile
Completing an ambulatory blood pressure assessment - Correct Answer-
✔✔Completing an ambulatory BP assessment.
Assessing blood pressure in a location of comfort like the home environment when
no professional is present will enable the ability to determine his blood pressure
under routine circumstances.
, A 58-year-old woman comes in complaining of retrosternal chest pain, worsening
with recumbent position. She states she has had a low-grade fever for two days.
Upon exam, the patient has a friction rub. An EKG reveals sinus tachycardia with
inflammatory changes. An ultrasound is performed, and she is diagnosed with an
acute pericarditis.
Which condition would make pericarditis more likely in this patient?
Stroke
Hypertension
Lupus
Asthma - Correct Answer-✔✔Lupus
Lupus is an autoimmune disorder that is often responsible for causing an
inflammatory response in the pericardial sac. Autoimmune disorders are known to
cause chronic pericarditis.
A 54-year-old Caucasian man comes in for a lab review. His lipids reveal an LDL of
180, an HDL of 52, and triglycerides of 326. He has no history of atherosclerotic
cardiovascular disease (ASCVD) or diabetes. His blood pressure is 118/64. He has a
pulse rate of 64, and he weighs 320 lb. He smokes one pack of cigarettes per day,
and his ASCVD risk score is 12.8.
Which medication should this patient be started on?
Fenofibrate (Tricor) 145mg
Ezetimibe (Zetia) 10mg
Atorvastatin (Lipitor) 20mg
Ibuprofen (Motrin) 200mg - Correct Answer-✔✔Atorvastatin (Lipitor) 20mg