Nurs 5315 MSK – Questions With Actual
Solutions
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Terms in this set (88)
Which bone cell is c. Osteoclast
primarily responsible for
bone resorption?
a. Osteoblast
b. Osteocyte
c. Osteoclast
d. Chondrocyte
What signaling molecule b. Sclerostin
secreted by osteocytes
inhibits osteoblast
activity?
a. RANK
b. Sclerostin
c. Cathepsin K
d. Osteocalcin
Which of the following is b. Osteocalcin
a biochemical marker of
osteoblast activity?
a. Tartrate-resistant acid
phosphatase (TRAP)
b. Osteocalcin
c. Cathepsin K
d. Matrix
metalloproteinases
(MMPs)
,What is the primary c. Maintaining bone homeostasis
function of osteocytes
within the bone matrix?
a. Synthesizing osteoid
b. Resorbing bone tissue
c. Maintaining bone
homeostasis
d. Initiating fracture
repair
Which enzyme is b. Cathepsin K
secreted by osteoclasts
to degrade the collagen
matrix?
a. Alkaline phosphatase
b. Cathepsin K
c. Acid phosphatase
d. Osteopontin
True or False: False (Osteoblasts originate from mesenchymal
Osteoblasts originate stem cells.)
from hematopoietic stem
cells.
True or False: The True
RANKL/OPG ratio is
critical in regulating
osteoclast activity.
True or False:Sclerostin False (Sclerostin production decreases in response
production by to mechanical loading.)
osteocytes is increased in
response to mechanical
loading.
True or False: Vitamin D False (Vitamin D deficiency impairs calcium
deficiency leads to absorption, while Vitamin C deficiency affects
impaired collagen collagen synthesis.)
synthesis in the bone
matrix.
, True or False: Osteocytes True
communicate with
neighboring cells
through dendritic
processes in canaliculi.
What is the role of the b. OPG binds to RANKL, preventing its interaction
RANK/RANKL/OPG with RANK, thereby inhibiting osteoclast activity.
system in bone
remodeling?
a. RANK/RANKL
interaction promotes
osteoblast differentiation
and activity, leading to
bone formation.
b. OPG binds to RANKL,
preventing its interaction
with RANK, thereby
inhibiting osteoclast
activity
.c. OPG promotes
osteoclast differentiation
and increases bone
resorption.
d. RANK/RANKL
interaction inhibits
osteoblast activity,
reducing bone formation.
Solutions
Save
Terms in this set (88)
Which bone cell is c. Osteoclast
primarily responsible for
bone resorption?
a. Osteoblast
b. Osteocyte
c. Osteoclast
d. Chondrocyte
What signaling molecule b. Sclerostin
secreted by osteocytes
inhibits osteoblast
activity?
a. RANK
b. Sclerostin
c. Cathepsin K
d. Osteocalcin
Which of the following is b. Osteocalcin
a biochemical marker of
osteoblast activity?
a. Tartrate-resistant acid
phosphatase (TRAP)
b. Osteocalcin
c. Cathepsin K
d. Matrix
metalloproteinases
(MMPs)
,What is the primary c. Maintaining bone homeostasis
function of osteocytes
within the bone matrix?
a. Synthesizing osteoid
b. Resorbing bone tissue
c. Maintaining bone
homeostasis
d. Initiating fracture
repair
Which enzyme is b. Cathepsin K
secreted by osteoclasts
to degrade the collagen
matrix?
a. Alkaline phosphatase
b. Cathepsin K
c. Acid phosphatase
d. Osteopontin
True or False: False (Osteoblasts originate from mesenchymal
Osteoblasts originate stem cells.)
from hematopoietic stem
cells.
True or False: The True
RANKL/OPG ratio is
critical in regulating
osteoclast activity.
True or False:Sclerostin False (Sclerostin production decreases in response
production by to mechanical loading.)
osteocytes is increased in
response to mechanical
loading.
True or False: Vitamin D False (Vitamin D deficiency impairs calcium
deficiency leads to absorption, while Vitamin C deficiency affects
impaired collagen collagen synthesis.)
synthesis in the bone
matrix.
, True or False: Osteocytes True
communicate with
neighboring cells
through dendritic
processes in canaliculi.
What is the role of the b. OPG binds to RANKL, preventing its interaction
RANK/RANKL/OPG with RANK, thereby inhibiting osteoclast activity.
system in bone
remodeling?
a. RANK/RANKL
interaction promotes
osteoblast differentiation
and activity, leading to
bone formation.
b. OPG binds to RANKL,
preventing its interaction
with RANK, thereby
inhibiting osteoclast
activity
.c. OPG promotes
osteoclast differentiation
and increases bone
resorption.
d. RANK/RANKL
interaction inhibits
osteoblast activity,
reducing bone formation.
