GMS6552 EXAM Questions AND Correct Answers
a GRK inhibitor would have what effect on GPCR inactivation in the presence of
a GPCR agonist?
•it would decrease it
•it would maintain the same rate of inactivation
•it would increase it - ✔✔it would decrease it
assume you have receptor antagonists that are able to stop receptor signaling
immediately. for which type of receptor would it take the longest to see the
effects of your drug at the cellular level?
•kinase linked receptors
•channel linked receptors
•nuclear receptors
•G protein coupled receptors - ✔✔nuclear receptors
based on figure 6D, what would be expected to happen if ATF4, CHOP, and
XBP1s were knocked out or inhibited in cells overexpressing EGFR?
•cell death upon treatment with tcyDTO would increase
•cells would still die upon treatment with tcyDTO, but to a lesser extent
•cells would no longer respond to tcyDTO - ✔✔cells would still die upon
treatment with tcyDTO, but to a lesser extent
,based on the effects on NF-kappaB signaling, would cancer cells be expected to
increase or decrease its activity for their own benefit?
•increase
•decrease - ✔✔increase
beta-arrestin has what effect on ERK signaling?
•increases it
•has no effect on it
•decreases it - ✔✔increases it
death ligands directly activate the ___ apoptotic pathway.
•intrinsic
•extrinsic - ✔✔extrinsic
different Smad complexes bind different genes. which group of Smads is
responsible for this specificity?
•R-Smads
•Co-Smads
•I-Smads - ✔✔R-Smads
does TGF-beta treatment cause cells to grow more or less in the soft agar assay?
, •more
•less - ✔✔more
does the presence of oncogenes make it harder or easier to develop selective
anti cancer agents with fewer side effects?
•harder
•easier - ✔✔easier
for which type of receptor would having adequate membrane permeability of
an agonist be most critical?
•kinase linked receptors
•channel linked receptors
•nuclear receptors
•G protein coupled receptors - ✔✔nuclear receptors
from figure 5B alone, which conclusion can be drawn?
•tcyDTO causes cell death through the extrinsic apoptosis pathway
•tcyDTO causes cell death through the intrinsic apoptosis pathway
•tcyDTO causes cell death through the apoptosis pathway
•tcyDTO does not cause cell death through the apoptosis pathway - ✔✔tcyDTO
causes cell death through the apoptosis pathway
a GRK inhibitor would have what effect on GPCR inactivation in the presence of
a GPCR agonist?
•it would decrease it
•it would maintain the same rate of inactivation
•it would increase it - ✔✔it would decrease it
assume you have receptor antagonists that are able to stop receptor signaling
immediately. for which type of receptor would it take the longest to see the
effects of your drug at the cellular level?
•kinase linked receptors
•channel linked receptors
•nuclear receptors
•G protein coupled receptors - ✔✔nuclear receptors
based on figure 6D, what would be expected to happen if ATF4, CHOP, and
XBP1s were knocked out or inhibited in cells overexpressing EGFR?
•cell death upon treatment with tcyDTO would increase
•cells would still die upon treatment with tcyDTO, but to a lesser extent
•cells would no longer respond to tcyDTO - ✔✔cells would still die upon
treatment with tcyDTO, but to a lesser extent
,based on the effects on NF-kappaB signaling, would cancer cells be expected to
increase or decrease its activity for their own benefit?
•increase
•decrease - ✔✔increase
beta-arrestin has what effect on ERK signaling?
•increases it
•has no effect on it
•decreases it - ✔✔increases it
death ligands directly activate the ___ apoptotic pathway.
•intrinsic
•extrinsic - ✔✔extrinsic
different Smad complexes bind different genes. which group of Smads is
responsible for this specificity?
•R-Smads
•Co-Smads
•I-Smads - ✔✔R-Smads
does TGF-beta treatment cause cells to grow more or less in the soft agar assay?
, •more
•less - ✔✔more
does the presence of oncogenes make it harder or easier to develop selective
anti cancer agents with fewer side effects?
•harder
•easier - ✔✔easier
for which type of receptor would having adequate membrane permeability of
an agonist be most critical?
•kinase linked receptors
•channel linked receptors
•nuclear receptors
•G protein coupled receptors - ✔✔nuclear receptors
from figure 5B alone, which conclusion can be drawn?
•tcyDTO causes cell death through the extrinsic apoptosis pathway
•tcyDTO causes cell death through the intrinsic apoptosis pathway
•tcyDTO causes cell death through the apoptosis pathway
•tcyDTO does not cause cell death through the apoptosis pathway - ✔✔tcyDTO
causes cell death through the apoptosis pathway
