GMS 6552 EXAM Questions AND Correct Answers
A GRK inhibitor would have what effect on GPCR inactivation in the presence of
a GPCR agonist? - ✔✔It would decrease it
Assume you have receptor antagonists that are able to stop receptor signaling
immediately. For which type of receptor would it take the longestto see the
effects of your drug at the cellular level? - ✔✔Nuclear receptors
Based on the effects of Nf-κB signaling, would cancer cells be expected to
increase or decrease its activity for their own benefit? - ✔✔Increase
Death ligands directly activate the ______ apoptotic pathway. - ✔✔extrinsic
Different Smad complexes bind different genes. Which group of Smads is
responsible for this specificity? - ✔✔R-Smads
Does TGF-β treatment cause cells to grow more or less in the soft-agar assay? -
✔✔More
For which type of receptor would having adequate membrane permeability of
an agonist be most critical? - ✔✔Nuclear receptors
How is the activity of the IKK complex modulated in order to determine whether
the complex feeds into the canonical or non-canonical signaling pathway? -
✔✔If the complex includes phosphorylated IKKβ, it feeds into the canonical
pathway. If the complex includes phosphorylated IKKα, it feeds into the non-
canonical pathway.
, How many DNA binding domains do Smads have? - ✔✔1
In the TGF-β pathway, which protein becomes activated first upon binding of a
ligand? - ✔✔TGFβR2
Is it more likely for a G-protein coupled receptor agonist to bind near the N- or
C- terminus of the receptor? - ✔✔N-terminus
Is it more likely to find a GPCR bound to a G-protein that is also bound to GTP or
GDP? - ✔✔GDP
Many phospholipase C enzymes contain pleckstrin homology domains. What is
the function of these domains? - ✔✔Bind phosphotidylinositol
Observation of which off the following would be an indication of ongoing
apoptosis? - ✔✔Membrane blebbing
Overexpression of the BAK protein would be expected to _____ the rate of
apoptosis. - ✔✔increase
PI3K is an ______ protein. - ✔✔intracellular
PLC exerts some of its effects through the modulation of which physiological
ion? - ✔✔Calcium
A GRK inhibitor would have what effect on GPCR inactivation in the presence of
a GPCR agonist? - ✔✔It would decrease it
Assume you have receptor antagonists that are able to stop receptor signaling
immediately. For which type of receptor would it take the longestto see the
effects of your drug at the cellular level? - ✔✔Nuclear receptors
Based on the effects of Nf-κB signaling, would cancer cells be expected to
increase or decrease its activity for their own benefit? - ✔✔Increase
Death ligands directly activate the ______ apoptotic pathway. - ✔✔extrinsic
Different Smad complexes bind different genes. Which group of Smads is
responsible for this specificity? - ✔✔R-Smads
Does TGF-β treatment cause cells to grow more or less in the soft-agar assay? -
✔✔More
For which type of receptor would having adequate membrane permeability of
an agonist be most critical? - ✔✔Nuclear receptors
How is the activity of the IKK complex modulated in order to determine whether
the complex feeds into the canonical or non-canonical signaling pathway? -
✔✔If the complex includes phosphorylated IKKβ, it feeds into the canonical
pathway. If the complex includes phosphorylated IKKα, it feeds into the non-
canonical pathway.
, How many DNA binding domains do Smads have? - ✔✔1
In the TGF-β pathway, which protein becomes activated first upon binding of a
ligand? - ✔✔TGFβR2
Is it more likely for a G-protein coupled receptor agonist to bind near the N- or
C- terminus of the receptor? - ✔✔N-terminus
Is it more likely to find a GPCR bound to a G-protein that is also bound to GTP or
GDP? - ✔✔GDP
Many phospholipase C enzymes contain pleckstrin homology domains. What is
the function of these domains? - ✔✔Bind phosphotidylinositol
Observation of which off the following would be an indication of ongoing
apoptosis? - ✔✔Membrane blebbing
Overexpression of the BAK protein would be expected to _____ the rate of
apoptosis. - ✔✔increase
PI3K is an ______ protein. - ✔✔intracellular
PLC exerts some of its effects through the modulation of which physiological
ion? - ✔✔Calcium
