Psychopharmacology of Substance Use Disorders UPDATED ACTUAL
Questions and CORRECT Answers
1. Up to 80% risk of development of Alcohol Use Disorder Antisocial Personality Dis-
& Substance Use Disorder in those with WHAT PER- order
SONALITY D/O? (When extreme impulsivi-
ty & disinhibition are pre-
sent)
2. Relapse occurs as a result of changes within the brain GLUTAMATE
d/t chronic drug use. (by stimuli r/t drug seek-
ing behaviors that inner-
In particular, activation of WHAT neurotransmitter? vate the NaC & VTA)
3. Chronic drug use can alter WHAT structure which is Dorsolateral Prefrontal
responsible for integrating sensory information from Cortex (DLPFC)
other areas within the cortex and mediation of execu-
tive functions and cognitive activities?
FYI, these are important for impulse control.
4. What 2 neurotransmitters are increased in ETOH con- Serotonin & Dopamine
sumption?
5. Genetic variations noted in WHAT Substance Use Dis- Stimulants Use Disorder
order include the variation at RGS17, found to regulate
G-protein signaling?
6. During chronic drug use, the amygdala develops con- Thalamus, which then
nections amongst stimuli present at the time of drug routes information to the
use & the reinforcing effects of the drug. Cerebral Cortex & Pre-
frontal Cortex
Structures that these connections come in contact with
are what?
7. RELAPSE
, Glutamate signaling re-engages neural connections
that provide incentive value, such as a state of wanting,
also known as TRIGGERS.
THIS IS WHAT STAGE OF ADDICTION?
8. Learning & memory are involved in the pathology of Amygdala
addiction.
What anatomical region in the brain is associated with
emotional events such as reward effects as in those of
chronic drug use?
9. Variations in DAT SLC6A3 are associated with WHAT Crack Cocaine
narcotic?
10. Variations in Adenosine A2A Receptor, BDNF, GDNF, & Amphetamine Use Disor-
PROKR2 are associated w/ WHAT Substance Use Disor- der
der?
11. What drug is a full receptor agonist, which suppresses Methadone
withdrawal symptoms fully when administered daily μ-opioid receptor agonists
via oral route?
12. μ-opioid receptor agonists such as Methadone & par- opioid use disorder
tial agonists such as Buprenorphine are used in the
treatment of WHAT substance use disorder?
13. There are two cannabinoid receptors in the brain that CB2
act to mediate the behavioral & psychological effects
of THC: CB1 & CB2.
WHICH RECEPTOR IS PART OF THE IMMUNE SYSTEM
WHERE THEY MODULATE "inflammatory responses?"
Questions and CORRECT Answers
1. Up to 80% risk of development of Alcohol Use Disorder Antisocial Personality Dis-
& Substance Use Disorder in those with WHAT PER- order
SONALITY D/O? (When extreme impulsivi-
ty & disinhibition are pre-
sent)
2. Relapse occurs as a result of changes within the brain GLUTAMATE
d/t chronic drug use. (by stimuli r/t drug seek-
ing behaviors that inner-
In particular, activation of WHAT neurotransmitter? vate the NaC & VTA)
3. Chronic drug use can alter WHAT structure which is Dorsolateral Prefrontal
responsible for integrating sensory information from Cortex (DLPFC)
other areas within the cortex and mediation of execu-
tive functions and cognitive activities?
FYI, these are important for impulse control.
4. What 2 neurotransmitters are increased in ETOH con- Serotonin & Dopamine
sumption?
5. Genetic variations noted in WHAT Substance Use Dis- Stimulants Use Disorder
order include the variation at RGS17, found to regulate
G-protein signaling?
6. During chronic drug use, the amygdala develops con- Thalamus, which then
nections amongst stimuli present at the time of drug routes information to the
use & the reinforcing effects of the drug. Cerebral Cortex & Pre-
frontal Cortex
Structures that these connections come in contact with
are what?
7. RELAPSE
, Glutamate signaling re-engages neural connections
that provide incentive value, such as a state of wanting,
also known as TRIGGERS.
THIS IS WHAT STAGE OF ADDICTION?
8. Learning & memory are involved in the pathology of Amygdala
addiction.
What anatomical region in the brain is associated with
emotional events such as reward effects as in those of
chronic drug use?
9. Variations in DAT SLC6A3 are associated with WHAT Crack Cocaine
narcotic?
10. Variations in Adenosine A2A Receptor, BDNF, GDNF, & Amphetamine Use Disor-
PROKR2 are associated w/ WHAT Substance Use Disor- der
der?
11. What drug is a full receptor agonist, which suppresses Methadone
withdrawal symptoms fully when administered daily μ-opioid receptor agonists
via oral route?
12. μ-opioid receptor agonists such as Methadone & par- opioid use disorder
tial agonists such as Buprenorphine are used in the
treatment of WHAT substance use disorder?
13. There are two cannabinoid receptors in the brain that CB2
act to mediate the behavioral & psychological effects
of THC: CB1 & CB2.
WHICH RECEPTOR IS PART OF THE IMMUNE SYSTEM
WHERE THEY MODULATE "inflammatory responses?"
