NR547 WEEK 8 EXAM REVIEW NOTES
– HIGH-YIELD TOPICS SIMPLIFIED
FOR EASY LEARNING
the recurrent use of a substance, such as alcohol or drugs, causes clinically significant
impairment
-including health problems, disability, or failure to meet responsibilities at home, work, or
school - correct answers ✔✔Substance use disorder occurs when:
With repeated ingestion of a drug, the drug shows decreased effect. Increasing doses
are required to achieve the effects noted with the original administration - correct
answers ✔✔Tolerance
State of adaptation produced with repeated administration of certain drugs so that
physical symptoms occur when the drug is discontinued abruptly. - correct answers
✔✔Dependence
,A change in behavior caused by biochemical changes in the brain after continued
substance use characterized by preoccupation with and repeated use of a substance
despite of negative outcomes. - correct answers ✔✔Addiction
Physiological and psychological reactions that occur when the use of a substance is
stopped abruptly. - correct answers ✔✔Withdrawal
Condition following the ingestion of a substance resulting in changes in level of
consciousness, cognition, perception, judgment, and behavior. - correct answers
✔✔Intoxication
Methadone
Methadone is a full μ-receptor agonist with a long half-life, which can prevent withdrawal
symptoms for 24 hours and provide steady control of cravings throughout the day. It is
only administered in methadone federally regulated opioid treatment programs (OTP).
Methadone clinics incorporate psychosocial interventions and require daily attendance
for the first several months, so this is a good option for a client that has the flexibility to
attend daily meetings. Use of methadone in MAT for opioid use disorder helps extend
client survival. When patients stop methadone, they have a high likelihood of relapsing,
even 10 years after starting treatment. - correct answers ✔✔Bernita is a 64-year-old
who has been using heroin for 6 years. She is currently unemployed and lives with her
daughter in the city center. She does not have health insurance.
prescribe the proper medication:
Methadone
Buprenorphine
Buprenorphine plus naloxone (Suboxone)
Naltrexone
Buprenorphine plus naloxone (Suboxone)
In combination with naloxone (Suboxone): naloxone is a mu opioid receptor antagonist
and can therefore block the effects of buprenorphine; however, because naloxone has
poor sublingual bioavailability, it does not interfere with buprenorphine's effects when
used properly. Naloxone does have good parenteral bioavailability; thus, if one tries to
administer the buprenorphine/naloxone formulation intravenously, naloxone will prevent
any rewarding effects from buprenorphine, making this drug a less desirable street drug.
Suboxone is a good option for a client who may not be able to leave work for medication
dosing, as it does not need to be taken under direct observation. - correct answers
✔✔Antoine is a 34-year-old who has been abusing prescription oxycodone. He is
employed but is on probation at work for increased absenteeism. He desires MAT but is
concerned about his roommates stealing his medication to get high.
prescribe the proper medication:
Methadone
, Buprenorphine
Buprenorphine plus naloxone (Suboxone)
Naltrexone
Naltrexone
Naltrexone blocks mu opioid receptors, preventing exogenous opioids from binding
there and thus preventing the pleasurable effects of opioid consumption. This
medication also reduces alcohol consumption through modulation of opioid systems,
thereby reducing the reinforcing effects of alcohol. For those patients with alcohol use
disorder, who have poor adherence to a regimen, and are unable to maintain
abstinence, long-acting injection naltrexone (Vivitrol) administered monthly can be
efficacious. - correct answers ✔✔Lisa is a 29-year-old who admits to using "pills, heroin,
and booze" regularly. She lives in a rural area and is employed part-time. She has a
history of poor compliance with past treatments.
prescribe the proper medication:
Methadone
Buprenorphine
Buprenorphine plus naloxone (Suboxone)
Naltrexone
Buprenorphine
Buprenorphine is a partial opioid agonist which binds with strong affinity to the mu
opioid receptor, preventing exogenous opioids from binding at the receptor site,
preventing the pleasurable effects of opioid consumption. Buprenorphine is the
recommended MAT for pregnant women who use opioids. - correct answers
✔✔Miranda is a 20-year-old who is 18 weeks pregnant and uses heroin. She wants to
get clean "for her baby."
prescribe the proper medication:
Methadone
Buprenorphine
Buprenorphine plus naloxone (Suboxone)
Naltrexone
Naltrexone
Naltrexone is a good option for clients who use opioids and alcohol and are committed
to abstinence. - correct answers ✔✔Juan is a 19-year-old who has a history of using
oxycodone that he has taken from his grandfather and drinking occasional alcohol. He
wants to stop using both substances.
prescribe the proper medication:
Bupropion
– HIGH-YIELD TOPICS SIMPLIFIED
FOR EASY LEARNING
the recurrent use of a substance, such as alcohol or drugs, causes clinically significant
impairment
-including health problems, disability, or failure to meet responsibilities at home, work, or
school - correct answers ✔✔Substance use disorder occurs when:
With repeated ingestion of a drug, the drug shows decreased effect. Increasing doses
are required to achieve the effects noted with the original administration - correct
answers ✔✔Tolerance
State of adaptation produced with repeated administration of certain drugs so that
physical symptoms occur when the drug is discontinued abruptly. - correct answers
✔✔Dependence
,A change in behavior caused by biochemical changes in the brain after continued
substance use characterized by preoccupation with and repeated use of a substance
despite of negative outcomes. - correct answers ✔✔Addiction
Physiological and psychological reactions that occur when the use of a substance is
stopped abruptly. - correct answers ✔✔Withdrawal
Condition following the ingestion of a substance resulting in changes in level of
consciousness, cognition, perception, judgment, and behavior. - correct answers
✔✔Intoxication
Methadone
Methadone is a full μ-receptor agonist with a long half-life, which can prevent withdrawal
symptoms for 24 hours and provide steady control of cravings throughout the day. It is
only administered in methadone federally regulated opioid treatment programs (OTP).
Methadone clinics incorporate psychosocial interventions and require daily attendance
for the first several months, so this is a good option for a client that has the flexibility to
attend daily meetings. Use of methadone in MAT for opioid use disorder helps extend
client survival. When patients stop methadone, they have a high likelihood of relapsing,
even 10 years after starting treatment. - correct answers ✔✔Bernita is a 64-year-old
who has been using heroin for 6 years. She is currently unemployed and lives with her
daughter in the city center. She does not have health insurance.
prescribe the proper medication:
Methadone
Buprenorphine
Buprenorphine plus naloxone (Suboxone)
Naltrexone
Buprenorphine plus naloxone (Suboxone)
In combination with naloxone (Suboxone): naloxone is a mu opioid receptor antagonist
and can therefore block the effects of buprenorphine; however, because naloxone has
poor sublingual bioavailability, it does not interfere with buprenorphine's effects when
used properly. Naloxone does have good parenteral bioavailability; thus, if one tries to
administer the buprenorphine/naloxone formulation intravenously, naloxone will prevent
any rewarding effects from buprenorphine, making this drug a less desirable street drug.
Suboxone is a good option for a client who may not be able to leave work for medication
dosing, as it does not need to be taken under direct observation. - correct answers
✔✔Antoine is a 34-year-old who has been abusing prescription oxycodone. He is
employed but is on probation at work for increased absenteeism. He desires MAT but is
concerned about his roommates stealing his medication to get high.
prescribe the proper medication:
Methadone
, Buprenorphine
Buprenorphine plus naloxone (Suboxone)
Naltrexone
Naltrexone
Naltrexone blocks mu opioid receptors, preventing exogenous opioids from binding
there and thus preventing the pleasurable effects of opioid consumption. This
medication also reduces alcohol consumption through modulation of opioid systems,
thereby reducing the reinforcing effects of alcohol. For those patients with alcohol use
disorder, who have poor adherence to a regimen, and are unable to maintain
abstinence, long-acting injection naltrexone (Vivitrol) administered monthly can be
efficacious. - correct answers ✔✔Lisa is a 29-year-old who admits to using "pills, heroin,
and booze" regularly. She lives in a rural area and is employed part-time. She has a
history of poor compliance with past treatments.
prescribe the proper medication:
Methadone
Buprenorphine
Buprenorphine plus naloxone (Suboxone)
Naltrexone
Buprenorphine
Buprenorphine is a partial opioid agonist which binds with strong affinity to the mu
opioid receptor, preventing exogenous opioids from binding at the receptor site,
preventing the pleasurable effects of opioid consumption. Buprenorphine is the
recommended MAT for pregnant women who use opioids. - correct answers
✔✔Miranda is a 20-year-old who is 18 weeks pregnant and uses heroin. She wants to
get clean "for her baby."
prescribe the proper medication:
Methadone
Buprenorphine
Buprenorphine plus naloxone (Suboxone)
Naltrexone
Naltrexone
Naltrexone is a good option for clients who use opioids and alcohol and are committed
to abstinence. - correct answers ✔✔Juan is a 19-year-old who has a history of using
oxycodone that he has taken from his grandfather and drinking occasional alcohol. He
wants to stop using both substances.
prescribe the proper medication:
Bupropion
