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Test Bank for Harrison’s Principles of Internal Medicine | 21st Edition (2025/2026 Update) | Joseph Loscalzo, Anthony Fauci, Dennis Kasper, Stephen Hauser, Dan Longo, J. Larry Jameson | Advanced Clinical Scenarios + Rationales

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The 2025/2026 updated Test Bank for Harrison’s Principles of Internal Medicine (21st Edition) provides an in-depth collection of clinical scenario–based MCQs spanning all major specialties — from cardiology and endocrinology to infectious diseases and oncology. Each question is crafted to promote critical reasoning, diagnostic accuracy, and evidence-based clinical decision-making, supported by comprehensive rationales. Perfect for medical students, residents, and nurse practitioners preparing for USMLE, NCLEX®, or internal medicine board exams.

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Test Bank for Harrison's Principles of Internal
Medicine, 21e Joseph Loscalzo, Anthony Fauci,
Dennis Kasper, Stephen Hauser, Dan Longo, J. Larry
Jameson




Part 1: The Profession of Medicine
Chapter 1: The Practice of Medicine

1. What is the primary focus of patient-centered care in contemporary
medicine?

A. The physician’s expertise

B. The patient’s preferences and values

C. Advanced diagnostic technologies

D. Insurance coverage

Answer: B. The patient’s preferences and values

Rationale: Patient-centered care emphasizes understanding and
respecting the patient’s individual preferences, values, and needs, and
involves them in all aspects of their treatment plan.

,2. Which of the following principles is essential in practicing
evidence-based medicine?

A. Reliance on clinical experience alone

B. Prioritizing patient wishes over scientific evidence

C. Using the best available research evidence

D. Avoiding consideration of healthcare costs

Answer: C. Using the best available research evidence

Rationale: Evidence-based medicine integrates clinical expertise with the
best available research evidence and patient values to guide clinical
decision-making.

3. A 60-year-old woman presents with chronic back pain. After
reviewing her imaging results, the clinician suggests a patient-
centered care approach. What does patient-centered care prioritize?

A. Clinician’s diagnosis

B. Medical costs

C. Patient’s preferences and involvement in decision-making

D. Strict adherence to clinical guidelines

Answer: C. Patient’s preferences and involvement in decision-making

Rationale: Patient-centered care emphasizes the importance of
understanding the patient’s individual preferences and involving them in the
decision-making process.



4. Which of the following is NOT a core principle of patient-centered
care?

,A. Respect for the patient’s values

B. Making decisions without consulting the patient

C. Providing clear communication

D. Emotional support

Answer: B. Making decisions without consulting the patient

Rationale: A core principle of patient-centered care is to involve the patient
in decision-making and respect their values and preferences.



5. A physician is considering two different treatment plans for a
patient with heart failure. Both treatments have similar efficacy, but
one is more expensive. How should the physician decide?

A. Choose the most expensive treatment

B. Choose based on the physician’s preference

C. Avoid discussing the costs with the patient

D. Include the patient in the decision and discuss the costs

Answer: D. Include the patient in the decision and discuss the costs

Rationale: Patient-centered care involves discussing the treatment
options, including the financial aspects, and allowing the patient to
participate in the decision.



6. Which of the following best defines evidence-based medicine?

A. Treating all patients the same way

B. Using the best available evidence, clinical expertise, and patient
preferences

, C. Relying on clinical trials exclusively

D. Ignoring patient preferences

Answer: B. Using the best available evidence, clinical expertise, and
patient preferences

Rationale: Evidence-based medicine combines clinical expertise, the best
available research, and consideration of patient values.



7. A 40-year-old patient is hesitant to take the recommended
treatment for diabetes due to fear of side effects. What is the best
approach to promote shared decision-making?

A. Ignore the patient's concerns

B. Provide the patient with clear information about risks and benefits

C. Prescribe the medication without further discussion

D. Reassure the patient without any explanation

Answer: B. Provide the patient with clear information about risks and
benefits

Rationale: Shared decision-making involves informing the patient about
risks, benefits, and alternatives, ensuring they have the information to
make an informed choice.



8. Which of the following is an advantage of using clinical decision
support systems (CDSS) in medicine?

A. Reduces diagnostic errors

B. Replaces clinician judgment

Connected book
 image
Joseph Loscalzo, Anthony S. Fauci, Dennis L. Kasper, Stephen Hauser, Dan Longo, J. Larry Jameson Harrison\'s Principles of Internal Medicine, Twenty-Second Edition (Vol.1 & Vol.2)
Publisher: 2025 ISBN: 9781265979522 Edition: Unknown

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