Hemostasis Harr Exam Questions with Verified Solutions 100% Verified
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1. which of the following initiates in vivo coagulation by activation of factor
VII?: tissue factor
2. which of the following is referred to as an endogenous activator of plasmino-
gen?: tissue plasminogen activator
3. which protein is the primary inhibitor of the fibrinolytic system?: a2- antiplasmin
4. which of the following statements is correct regarding the D-dimer test?: test
has a negative predictive value
5. a protein that plays a role in both coagulation and platelet aggregation
is:: factor I
6. a standard 4.5 mL blue top tube filled with 3 mL of blood was submitted to the
lab for PT and APTT tests. the sample is from a patient undergoing surgery the
following morning for a tonsillectomy. which of the following is the necessary
course of action by the tech?: reject the sample and request a new one
7. which statement is correct regarding sample storage for the prothrombin
time?: stable for 24 hours is the sample is capped
8. in primary fibrinolysis, the fibrinolytic activity results in response to:: spontaneous
activation of fibrinolysis
9. plasminogen deficiency is associated with:: thrombosis
10. which of the following clotting factors are activated by thrombin that is
generated by tissue pathway (TF-VIIa)?: V, VIII
11. what substrate is used in a chromogenic factor assay?: p-nitroanaline
12. which of the following antibodies is used in the D-dimer assay?: monoclonal against
D-dimer
13. thrombotic thromocytopenic purpura is characterized by:: increased platelet aggre-
gation
14. thrombocytopenia may be associated with:: hypersplenism
15. aspirin prevents platelet aggregation by inhibiting the action of which en-
zyme?: cyclo-oxygenase
16. normal platelet adhesion depends upon:: glycoprotein Ib
17. which of the following test results is normal in a patient with classic von
Willebrands disease?: platelet count
18. bernard-soulier syndrome is associated with:: thrombocytopenia and giant platelets
1/7
, Hemostasis Harr Exam Questions with Verified Solutions 100% Verified
Study online at https://quizlet.com/_i2u1eg
19. when performing platelet aggregation studies, which set of platelet aggre-
gation results would most likely be associated with bernard-soulier syndrome?-
: normal platelet aggregation to collagen, ADP, and epinephrine; decreased aggregation to ristocetin
20. which set of platelet responses would be most likely associated with glanz-
manns thrombasthenia?: normal platelet aggregation to ristocetin; decreased aggregation to collagen,
ADP, and epinephrine
21. which of the following is a characteristic of acute immune thrombocytopenic
purpura?: spontaneous remission within a few weeks
22. TTP differs from DIC in that:: APTT is normal in TTP but prolonged in DIC
23. several hours after birth, a baby boy develops petechiae and purpura and a
hemorrhagic diathesis. the platelet count is 18x10^9. what is the most likely
explanation for the low platelet count?: neonatal alloimmune thrombocytopenia
24. which of the following is associated with post transfusion purpura (PTP)?: im-
mune mediated thrombocytopenia/alloantibodies
25. hemolytic uremic syndrome (HUS) is associated with:: E. Coli 0157
26. storage pool deficiencies are defects of:: platelet granules
27. lumi-aggregation measures:: platelet aggregation and ATP release
28. neurological findings may be commonly associated with which of the follow-
ing disorders?: TTP
29. which of the following is correct regarding acquired thrombotic thrombocy-
topenic purpura?: autoimmune disease
30. hereditary hemorrhage telangiectasia is a disorder of:: connective tissue
31. which of the following prevents platelet aggregation?: prostacyclin
32. which defect characterizes grays syndrome?: alpha granule defect
33. the P2Y12 ADP receptor agonist assay may be used to monitor platelet
aggregation inhibition to which of the following drugs?: clopidogrel (plavix)
34. which of the following instruments can be used to evaluate platelet func-
tion?: platelet aggregometer, verifynow, PFA 100
35. which of the following platelet aggregating agents demonstrates a
monophasic aggregation curve when used in optimal concentration?: collagen
36. the APTT is sensitive to a deficiency of which clotting factor?: factor X
2/7
Study online at https://quizlet.com/_i2u1eg
1. which of the following initiates in vivo coagulation by activation of factor
VII?: tissue factor
2. which of the following is referred to as an endogenous activator of plasmino-
gen?: tissue plasminogen activator
3. which protein is the primary inhibitor of the fibrinolytic system?: a2- antiplasmin
4. which of the following statements is correct regarding the D-dimer test?: test
has a negative predictive value
5. a protein that plays a role in both coagulation and platelet aggregation
is:: factor I
6. a standard 4.5 mL blue top tube filled with 3 mL of blood was submitted to the
lab for PT and APTT tests. the sample is from a patient undergoing surgery the
following morning for a tonsillectomy. which of the following is the necessary
course of action by the tech?: reject the sample and request a new one
7. which statement is correct regarding sample storage for the prothrombin
time?: stable for 24 hours is the sample is capped
8. in primary fibrinolysis, the fibrinolytic activity results in response to:: spontaneous
activation of fibrinolysis
9. plasminogen deficiency is associated with:: thrombosis
10. which of the following clotting factors are activated by thrombin that is
generated by tissue pathway (TF-VIIa)?: V, VIII
11. what substrate is used in a chromogenic factor assay?: p-nitroanaline
12. which of the following antibodies is used in the D-dimer assay?: monoclonal against
D-dimer
13. thrombotic thromocytopenic purpura is characterized by:: increased platelet aggre-
gation
14. thrombocytopenia may be associated with:: hypersplenism
15. aspirin prevents platelet aggregation by inhibiting the action of which en-
zyme?: cyclo-oxygenase
16. normal platelet adhesion depends upon:: glycoprotein Ib
17. which of the following test results is normal in a patient with classic von
Willebrands disease?: platelet count
18. bernard-soulier syndrome is associated with:: thrombocytopenia and giant platelets
1/7
, Hemostasis Harr Exam Questions with Verified Solutions 100% Verified
Study online at https://quizlet.com/_i2u1eg
19. when performing platelet aggregation studies, which set of platelet aggre-
gation results would most likely be associated with bernard-soulier syndrome?-
: normal platelet aggregation to collagen, ADP, and epinephrine; decreased aggregation to ristocetin
20. which set of platelet responses would be most likely associated with glanz-
manns thrombasthenia?: normal platelet aggregation to ristocetin; decreased aggregation to collagen,
ADP, and epinephrine
21. which of the following is a characteristic of acute immune thrombocytopenic
purpura?: spontaneous remission within a few weeks
22. TTP differs from DIC in that:: APTT is normal in TTP but prolonged in DIC
23. several hours after birth, a baby boy develops petechiae and purpura and a
hemorrhagic diathesis. the platelet count is 18x10^9. what is the most likely
explanation for the low platelet count?: neonatal alloimmune thrombocytopenia
24. which of the following is associated with post transfusion purpura (PTP)?: im-
mune mediated thrombocytopenia/alloantibodies
25. hemolytic uremic syndrome (HUS) is associated with:: E. Coli 0157
26. storage pool deficiencies are defects of:: platelet granules
27. lumi-aggregation measures:: platelet aggregation and ATP release
28. neurological findings may be commonly associated with which of the follow-
ing disorders?: TTP
29. which of the following is correct regarding acquired thrombotic thrombocy-
topenic purpura?: autoimmune disease
30. hereditary hemorrhage telangiectasia is a disorder of:: connective tissue
31. which of the following prevents platelet aggregation?: prostacyclin
32. which defect characterizes grays syndrome?: alpha granule defect
33. the P2Y12 ADP receptor agonist assay may be used to monitor platelet
aggregation inhibition to which of the following drugs?: clopidogrel (plavix)
34. which of the following instruments can be used to evaluate platelet func-
tion?: platelet aggregometer, verifynow, PFA 100
35. which of the following platelet aggregating agents demonstrates a
monophasic aggregation curve when used in optimal concentration?: collagen
36. the APTT is sensitive to a deficiency of which clotting factor?: factor X
2/7
