RBC exam
Study online at https://quizlet.com/_hsesfw
1. three areas of RBC metabolism that are crucial for normal erythrocyte survival
and function:: - RBC membrane
- hemoglobin structure and function
- RBC metabolic pathways
2. 3 layers of RBC membrane: - outer hydrophilic= glycolipid, glycoprotein, and protein
- central hydrophobic= protein, cholesterol, and phospholipid
- inner hydrophilic= contains proteins
**40% lipids, 52% proteins, and 8% carbs
3. 2 important proteins within the cell membrane: - sceptrin
- glycophorin
4. spectrin: - A fibrous protein that gives shape to an RBC plasma membrane.
- helps maintain biconcave shape and flexibility of RBC
- alpha and beta chain
5. glycophorin: integral membrane protein
- accounts for most of the sialic acid, which gives RBC neg charge
6. RBC permeability: - freely permeable to water and anions (Cl and HCO3)
- the more cholesterol the less permeable
7. target cells: cholesterol accumulation in the RBC membrane
- thalassemia, liver disease, asplenia, HbC disease
8. acanthocytes (spur cells): - Abetalipoproteinemia with cholesterol accumulation
- liver disease
9. hemolysis with RBC fragmentation: - LCAT deficiency with cholesterol accumulation
10. bite cells and spherocytes: - Decreased phosphorylated spectrin or altered spectrin
11. hemoglobin synthesis dependent on 3 processes: - adequate iron delivery
- adequate synthesis of protoporphyrin's
- adequate globin synthesis
1/4
Study online at https://quizlet.com/_hsesfw
1. three areas of RBC metabolism that are crucial for normal erythrocyte survival
and function:: - RBC membrane
- hemoglobin structure and function
- RBC metabolic pathways
2. 3 layers of RBC membrane: - outer hydrophilic= glycolipid, glycoprotein, and protein
- central hydrophobic= protein, cholesterol, and phospholipid
- inner hydrophilic= contains proteins
**40% lipids, 52% proteins, and 8% carbs
3. 2 important proteins within the cell membrane: - sceptrin
- glycophorin
4. spectrin: - A fibrous protein that gives shape to an RBC plasma membrane.
- helps maintain biconcave shape and flexibility of RBC
- alpha and beta chain
5. glycophorin: integral membrane protein
- accounts for most of the sialic acid, which gives RBC neg charge
6. RBC permeability: - freely permeable to water and anions (Cl and HCO3)
- the more cholesterol the less permeable
7. target cells: cholesterol accumulation in the RBC membrane
- thalassemia, liver disease, asplenia, HbC disease
8. acanthocytes (spur cells): - Abetalipoproteinemia with cholesterol accumulation
- liver disease
9. hemolysis with RBC fragmentation: - LCAT deficiency with cholesterol accumulation
10. bite cells and spherocytes: - Decreased phosphorylated spectrin or altered spectrin
11. hemoglobin synthesis dependent on 3 processes: - adequate iron delivery
- adequate synthesis of protoporphyrin's
- adequate globin synthesis
1/4
