PN Hesi Pharmacology Exam Prep Test Bank with 360
Questions and Correct Answers with Rationales // Hesi PN
Pharmacology 2025-2026 Latest Exam Practice Test Bank
1) The burn client is receiving treatments of topical mafenide acetate (Sulfamylon)
to the site of injury. The nurse monitors the client, knowing that which of the
following indicates that a systemic effect has occurred?
1.Hyperventilation
2.Elevated blood pressure
3.Local pain at the burn site
4.Local rash at the burn site - ANSWER-1.Hyperventilation
Rationale:
Mafenide acetate is a carbonic anhydrase inhibitor and can suppress renal excretion
of acid, thereby causing acidosis. Clients receiving this treatment should be
monitored for signs of an acid-base imbalance (hyperventilation). If this occurs, the
medication should be discontinued for 1 to 2 days. Options 3 and 4 describe local
rather than systemic effects. An elevated blood pressure may be expected from the
pain that occurs with a burn injury.
2.) A nurse is caring for a client who is receiving an intravenous (IV) infusion of
an antineoplastic medication. During the infusion, the client complains of pain at
the insertion site. During an inspection of the site, the nurse notes redness and
swelling and that the rate of infusion of the medication has slowed. The nurse
should take which appropriate action?
1. Notify the registered nurse.
2. Administer pain medication to reduce the discomfort.
3. Apply ice and maintain the infusion rate, as prescribed.
4. Elevate the extremity of the IV site, and slow the infusion. - ANSWER-1.
Notify the registered nurse.
pg. 1
,Rationale:
When antineoplastic medications (Chemotheraputic Agents) are administered via
IV, great care must be taken to prevent the medication from escaping into the
tissues surrounding the injection site, because pain, tissue damage, and necrosis
can result. The nurse monitors for signs of extravasation, such as redness or
swelling at the insertion site and a decreased infusion rate. If extravasation occurs,
the registered nurse needs to be notified; he or she will then contact the health care
provider.
3.) Salicylic acid is prescribed for a client with a diagnosis of psoriasis. The nurse
monitors the client, knowing that which of the following would indicate the
presence of systemic toxicity from this medication?
1. Tinnitus
2. Diarrhea
3. Constipation
4. Decreased respirations - ANSWER-1. Tinnitus
Rationale:
Salicylic acid is absorbed readily through the skin, and systemic toxicity
(salicylism) can result. Symptoms include tinnitus, dizziness, hyperpnea, and
psychological disturbances. Constipation and diarrhea are not associated with
salicylism.
4.) The camp nurse asks the children preparing to swim in the lake if they have
applied sunscreen. The nurse reminds the children that chemical sunscreens are
most effective when applied:
1. Immediately before swimming
2. 15 minutes before exposure to the sun
3. Immediately before exposure to the sun
4. At least 30 minutes before exposure to the sun - ANSWER-4. At least 30
minutes before exposure to the sun
pg. 2
,Rationale:
Sunscreens are most effective when applied at least 30 minutes before exposure to
the sun so that they can penetrate the skin. All sunscreens should be reapplied after
swimming or sweating.
5.) Mafenide acetate (Sulfamylon) is prescribed for the client with a burn injury.
When applying the medication, the client complains of local discomfort and
burning. Which of the following is the most appropriate nursing action?
1. Notifying the registered nurse
2. Discontinuing the medication
3. Informing the client that this is normal
4. Applying a thinner film than prescribed to the burn site - ANSWER-3.
Informing the client that this is normal
Rationale:
Mafenide acetate is bacteriostatic for gram-negative and gram-positive organisms
and is used to treat burns to reduce bacteria present in avascular tissues. The client
should be informed that the medication will cause local discomfort and burning
and that this is a normal reaction; therefore options 1, 2, and 4 are incorrect
6.) A nurse is caring for a client with hyperparathyroidism and notes that the
client's serum calcium level is 13 mg/dL. Which medication should the nurse
prepare to administer as prescribed to the client?
1. Calcium chloride
2. Calcium gluconate
3. Calcitonin (Miacalcin)
4. Large doses of vitamin D - ANSWER-3. Calcitonin (Miacalcin)
Rationale:
The normal serum calcium level is 8.6 to 10.0 mg/dL. This client is experiencing
hypercalcemia. Calcium gluconate and calcium chloride are medications used for
pg. 3
, the treatment of tetany, which occurs as a result of acute hypocalcemia. In
hypercalcemia, large doses of vitamin D need to be avoided. Calcitonin, a thyroid
hormone, decreases the plasma calcium level by inhibiting bone resorption and
lowering the serum calcium concentration.
7.) Isotretinoin is prescribed for a client with severe acne. Before the
administration of this medication, the nurse anticipates that which laboratory test
will be prescribed?
1. Platelet count
2. Triglyceride level
3. Complete blood count
4. White blood cell count - ANSWER-2. Triglyceride level
Rationale:
Isotretinoin can elevate triglyceride levels. Blood triglyceride levels should be
measured before treatment and periodically thereafter until the effect on the
triglycerides has been evaluated. Options 1, 3, and 4 do not need to be monitored
specifically during this treatment.
8.) A client with severe acne is seen in the clinic and the health care provider
(HCP) prescribes isotretinoin. The nurse reviews the client's medication record and
would contact the (HCP) if the client is taking which medication?
1. Vitamin A
2. Digoxin (Lanoxin)
3. Furosemide (Lasix)
4. Phenytoin (Dilantin) - ANSWER-1. Vitamin A
Rationale:
Isotretinoin is a metabolite of vitamin A and can produce generalized
intensification of isotretinoin toxicity. Because of the potential for increased
toxicity, vitamin A supplements should be discontinued before isotretinoin therapy.
Options 2, 3, and 4 are not contraindicated with the use of isotretinoin.
pg. 4
Questions and Correct Answers with Rationales // Hesi PN
Pharmacology 2025-2026 Latest Exam Practice Test Bank
1) The burn client is receiving treatments of topical mafenide acetate (Sulfamylon)
to the site of injury. The nurse monitors the client, knowing that which of the
following indicates that a systemic effect has occurred?
1.Hyperventilation
2.Elevated blood pressure
3.Local pain at the burn site
4.Local rash at the burn site - ANSWER-1.Hyperventilation
Rationale:
Mafenide acetate is a carbonic anhydrase inhibitor and can suppress renal excretion
of acid, thereby causing acidosis. Clients receiving this treatment should be
monitored for signs of an acid-base imbalance (hyperventilation). If this occurs, the
medication should be discontinued for 1 to 2 days. Options 3 and 4 describe local
rather than systemic effects. An elevated blood pressure may be expected from the
pain that occurs with a burn injury.
2.) A nurse is caring for a client who is receiving an intravenous (IV) infusion of
an antineoplastic medication. During the infusion, the client complains of pain at
the insertion site. During an inspection of the site, the nurse notes redness and
swelling and that the rate of infusion of the medication has slowed. The nurse
should take which appropriate action?
1. Notify the registered nurse.
2. Administer pain medication to reduce the discomfort.
3. Apply ice and maintain the infusion rate, as prescribed.
4. Elevate the extremity of the IV site, and slow the infusion. - ANSWER-1.
Notify the registered nurse.
pg. 1
,Rationale:
When antineoplastic medications (Chemotheraputic Agents) are administered via
IV, great care must be taken to prevent the medication from escaping into the
tissues surrounding the injection site, because pain, tissue damage, and necrosis
can result. The nurse monitors for signs of extravasation, such as redness or
swelling at the insertion site and a decreased infusion rate. If extravasation occurs,
the registered nurse needs to be notified; he or she will then contact the health care
provider.
3.) Salicylic acid is prescribed for a client with a diagnosis of psoriasis. The nurse
monitors the client, knowing that which of the following would indicate the
presence of systemic toxicity from this medication?
1. Tinnitus
2. Diarrhea
3. Constipation
4. Decreased respirations - ANSWER-1. Tinnitus
Rationale:
Salicylic acid is absorbed readily through the skin, and systemic toxicity
(salicylism) can result. Symptoms include tinnitus, dizziness, hyperpnea, and
psychological disturbances. Constipation and diarrhea are not associated with
salicylism.
4.) The camp nurse asks the children preparing to swim in the lake if they have
applied sunscreen. The nurse reminds the children that chemical sunscreens are
most effective when applied:
1. Immediately before swimming
2. 15 minutes before exposure to the sun
3. Immediately before exposure to the sun
4. At least 30 minutes before exposure to the sun - ANSWER-4. At least 30
minutes before exposure to the sun
pg. 2
,Rationale:
Sunscreens are most effective when applied at least 30 minutes before exposure to
the sun so that they can penetrate the skin. All sunscreens should be reapplied after
swimming or sweating.
5.) Mafenide acetate (Sulfamylon) is prescribed for the client with a burn injury.
When applying the medication, the client complains of local discomfort and
burning. Which of the following is the most appropriate nursing action?
1. Notifying the registered nurse
2. Discontinuing the medication
3. Informing the client that this is normal
4. Applying a thinner film than prescribed to the burn site - ANSWER-3.
Informing the client that this is normal
Rationale:
Mafenide acetate is bacteriostatic for gram-negative and gram-positive organisms
and is used to treat burns to reduce bacteria present in avascular tissues. The client
should be informed that the medication will cause local discomfort and burning
and that this is a normal reaction; therefore options 1, 2, and 4 are incorrect
6.) A nurse is caring for a client with hyperparathyroidism and notes that the
client's serum calcium level is 13 mg/dL. Which medication should the nurse
prepare to administer as prescribed to the client?
1. Calcium chloride
2. Calcium gluconate
3. Calcitonin (Miacalcin)
4. Large doses of vitamin D - ANSWER-3. Calcitonin (Miacalcin)
Rationale:
The normal serum calcium level is 8.6 to 10.0 mg/dL. This client is experiencing
hypercalcemia. Calcium gluconate and calcium chloride are medications used for
pg. 3
, the treatment of tetany, which occurs as a result of acute hypocalcemia. In
hypercalcemia, large doses of vitamin D need to be avoided. Calcitonin, a thyroid
hormone, decreases the plasma calcium level by inhibiting bone resorption and
lowering the serum calcium concentration.
7.) Isotretinoin is prescribed for a client with severe acne. Before the
administration of this medication, the nurse anticipates that which laboratory test
will be prescribed?
1. Platelet count
2. Triglyceride level
3. Complete blood count
4. White blood cell count - ANSWER-2. Triglyceride level
Rationale:
Isotretinoin can elevate triglyceride levels. Blood triglyceride levels should be
measured before treatment and periodically thereafter until the effect on the
triglycerides has been evaluated. Options 1, 3, and 4 do not need to be monitored
specifically during this treatment.
8.) A client with severe acne is seen in the clinic and the health care provider
(HCP) prescribes isotretinoin. The nurse reviews the client's medication record and
would contact the (HCP) if the client is taking which medication?
1. Vitamin A
2. Digoxin (Lanoxin)
3. Furosemide (Lasix)
4. Phenytoin (Dilantin) - ANSWER-1. Vitamin A
Rationale:
Isotretinoin is a metabolite of vitamin A and can produce generalized
intensification of isotretinoin toxicity. Because of the potential for increased
toxicity, vitamin A supplements should be discontinued before isotretinoin therapy.
Options 2, 3, and 4 are not contraindicated with the use of isotretinoin.
pg. 4
