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JACI PRIMER NEWEST 2025/2026 ACTUAL EXAM WITH COMPLETE
QUESTIONS AND CORRECT DETAILED ANSWERS (100% VERIFIED
ANSWERS) |ALREADY GRADED A+| ||PROFESSOR VERIFIED||
Question 1. The lifelong prevalence of anaphylaxis from all
triggers in the general population is estimated at —
A. 0.001%.
B. 0.01%.
C. 0.1%.
D. 0.05% to 2%. - ANSWER-1. Answer: D
Explanation: Accurate community-based population estimates are
difficult to obtain because of underdiagnosis, underreporting, and
miscoding; however, lifelong prevalence of anaphylaxis from all
triggers in the general population is estimated at 0.05% to 2%.
Question 2. You diagnose idiopathic anaphylaxis in a 50 year-old
woman who has had 2 episodes during the past year. What
should you do next?
A. Refer her for a bone marrow biopsy.
B. Measure her serum total tryptase level.
C. Advise her to avoid peanut, tree nuts, shellfish, and fish.
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D. Prescribe prednisone, 60 mg daily, for a week and then taper
the dose. - ANSWER-2. Answer: B
Explanation: In patients with newly diagnosed idiopathic
anaphylaxis, the serum total tryptase level should be measured.
This test reflects the increased burden of mast cells in all forms of
mastocytosis and is therefore an important screening test for
mastocytosis. If the total tryptase level is greater than 11.4 ng/mL,
the new upper limit of normal, meticulous examination for
cutaneous mastocytosis is indicated, and if the level is greater
than 20 ng/mL, a bone marrow biopsy is indicated, even if
cutaneous manifestations are absent.
Question 3. For which of the following is a 3- to 5-year course of
subcutaneous immunotherapy recommended based on
randomized, double-blind, placebo-controlled trials?
A. food-induced anaphylaxis
B. medication-induced anaphylaxis
C. stinging insect venom-induced anaphylaxis
D. natural rubber latex-induced anaphylaxis - ANSWER-3.
Answer: C
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Explanation: A 3- to 5-year course of subcutaneous injections of
the relevant standardized insect venom or venoms reduces the
risk of anaphylaxis from a subsequent sting, based on
randomized, double-blind, placebo-controlled trials. In children, a
98% protection rate can be achieved.
Question 4. Epinephrine is the drug of first choice in anaphylaxis
because —
A. its a1-adrenergic vasoconstrictor effects decrease mucosal
edema and increase peripheral vascular resistance.
B. its a2-adrenergic receptor effects decrease release of insulin
and norepinephrine.
C. its b1-adrenergic effects increase the rate and force of cardiac
contractions.
D. its b2-adrenergic effects increase bronchodilation and
decrease mediator release. - ANSWER-4. Answer: A
Explanation: Epinephrine's multiple pharmacologic effects in
many organ systems are useful in anaphylaxis; however, its a1-
adre- nergic vasoconstrictor effects in the small arterioles and
precapillary sphincters are unique among medications used in the
prehospital treatment of anaphylaxis. By decreasing mucosal
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edema, it prevents and relieves upper airway obstruction. It also
prevents and relieves hypotension and shock. When used in first-
aid treatment, prompt injection is important. The epinephrine
doses currently available in autoinjectors for outpatient use are
too low for use in cardiopulmonary resuscitation.
Question 4. Which of the following is a feature of defensins?
A. biochemical characterized as charge neutral molecules
B. They are primarily produced by Paneth cells.
C. They participate as an element of the acquired immune
system.
D. Three different types have been identified. - ANSWER-4.
Answer: B
Explanation: Defensins are synthesized primarily by Paneth cells
and function as one part of the innate immune system. Six
different subtypes of these highly charged molecules have been
thus far identified.
JACI PRIMER NEWEST 2025/2026 ACTUAL EXAM WITH COMPLETE
QUESTIONS AND CORRECT DETAILED ANSWERS (100% VERIFIED
ANSWERS) |ALREADY GRADED A+| ||PROFESSOR VERIFIED||
Question 1. The lifelong prevalence of anaphylaxis from all
triggers in the general population is estimated at —
A. 0.001%.
B. 0.01%.
C. 0.1%.
D. 0.05% to 2%. - ANSWER-1. Answer: D
Explanation: Accurate community-based population estimates are
difficult to obtain because of underdiagnosis, underreporting, and
miscoding; however, lifelong prevalence of anaphylaxis from all
triggers in the general population is estimated at 0.05% to 2%.
Question 2. You diagnose idiopathic anaphylaxis in a 50 year-old
woman who has had 2 episodes during the past year. What
should you do next?
A. Refer her for a bone marrow biopsy.
B. Measure her serum total tryptase level.
C. Advise her to avoid peanut, tree nuts, shellfish, and fish.
,2|Page
D. Prescribe prednisone, 60 mg daily, for a week and then taper
the dose. - ANSWER-2. Answer: B
Explanation: In patients with newly diagnosed idiopathic
anaphylaxis, the serum total tryptase level should be measured.
This test reflects the increased burden of mast cells in all forms of
mastocytosis and is therefore an important screening test for
mastocytosis. If the total tryptase level is greater than 11.4 ng/mL,
the new upper limit of normal, meticulous examination for
cutaneous mastocytosis is indicated, and if the level is greater
than 20 ng/mL, a bone marrow biopsy is indicated, even if
cutaneous manifestations are absent.
Question 3. For which of the following is a 3- to 5-year course of
subcutaneous immunotherapy recommended based on
randomized, double-blind, placebo-controlled trials?
A. food-induced anaphylaxis
B. medication-induced anaphylaxis
C. stinging insect venom-induced anaphylaxis
D. natural rubber latex-induced anaphylaxis - ANSWER-3.
Answer: C
,3|Page
Explanation: A 3- to 5-year course of subcutaneous injections of
the relevant standardized insect venom or venoms reduces the
risk of anaphylaxis from a subsequent sting, based on
randomized, double-blind, placebo-controlled trials. In children, a
98% protection rate can be achieved.
Question 4. Epinephrine is the drug of first choice in anaphylaxis
because —
A. its a1-adrenergic vasoconstrictor effects decrease mucosal
edema and increase peripheral vascular resistance.
B. its a2-adrenergic receptor effects decrease release of insulin
and norepinephrine.
C. its b1-adrenergic effects increase the rate and force of cardiac
contractions.
D. its b2-adrenergic effects increase bronchodilation and
decrease mediator release. - ANSWER-4. Answer: A
Explanation: Epinephrine's multiple pharmacologic effects in
many organ systems are useful in anaphylaxis; however, its a1-
adre- nergic vasoconstrictor effects in the small arterioles and
precapillary sphincters are unique among medications used in the
prehospital treatment of anaphylaxis. By decreasing mucosal
, 4|Page
edema, it prevents and relieves upper airway obstruction. It also
prevents and relieves hypotension and shock. When used in first-
aid treatment, prompt injection is important. The epinephrine
doses currently available in autoinjectors for outpatient use are
too low for use in cardiopulmonary resuscitation.
Question 4. Which of the following is a feature of defensins?
A. biochemical characterized as charge neutral molecules
B. They are primarily produced by Paneth cells.
C. They participate as an element of the acquired immune
system.
D. Three different types have been identified. - ANSWER-4.
Answer: B
Explanation: Defensins are synthesized primarily by Paneth cells
and function as one part of the innate immune system. Six
different subtypes of these highly charged molecules have been
thus far identified.
