Toxicology Exam quiz and answers
well graded A+
When considering the dose-response relationship for an essential substance______ -
ANS✅✅adverse responses increase in severity with increasing or decreasing dosages outside of
the homeostatic range.
T/F: Modern toxicology is concerned with the study of the adverse effects of chemicals on ancient
forms of life - ANS✅✅False
T/F. Modern toxicology studies embrace principles from such disciplines as biochemistry, botany,
chemistry, physiology, and physics. - ANS✅✅True
Knowledge of the toxicology of poisonous agents was published earliest in the _____ -
ANS✅✅Ebers papyrus
Paracelsus, a physician-alchemist, formulated many revolutionary views that remain integral to the
structure of toxicology, pharmacology, and therapeutics today. He focused on the primary toxic
agent as a chemical entity and articulated the dose-response relation. Describe 4 statements that
are attributable to Paracelsus - ANS✅✅1. Experimentation is essential in the examination of
responses to chemicals
2. One should make a distinction between the therapeutic and toxic properties of chemicals
3. These properties are sometimes but not always indistinguishable except by dose
4. One can ascertain a degree of specificity of chemicals and their therapeutic or toxic effects
Which modern toxicologist is credited with saying that "you can be a toxicologist in two easy lesions,
each of 10 years?" - ANS✅✅Arnold Lehman
T/F. Louis Lewin trained under Oswald Schmeideberg and published much of the early work on the
toxicity of narcotics, methanol, and chloroform - ANS✅✅True
, Harmful chemicals that are produced by living organisms - ANS✅✅Toxin
A term to denote any chemical that can
potentially produce harm - ANS✅✅toxicant
Xenobiotics - ANS✅✅means foreign to the body and can refer to any chemical that is not a natural
component of the body
Which physician is credited with being one of the first physicians to apply basic pharmacology and
toxicology principles to the practice of medicine, including
concepts of bioavailability and overdose. - ANS✅✅Hippocrates
This contains the recipes of more than 800 "medicinal" and poisonous preparations. It describes
poisons known at that time, including hemlock, later to be used as the state poison of the Greeks, as
well as opium, aconite (a Chinese arrow poison), and heavy metals such as lead, copper, and
antimony - ANS✅✅Ebers Papyrus
____may be very useful in
demonstrating that an adverse outcome
(e.g., cancer, birth defects) observed in
laboratory animals is directly relevant to
humans. - ANS✅✅Mechanistic toxicology
______Is concerned directly with toxicity testing,
which provides information for safety
evaluation and regulatory requirements. - ANS✅✅Descriptive toxicology
• Is concerned with deciding, whether a drug
or other chemical poses a sufficiently low
risk to be marketed for a stated purpose or
subsequent human or environmental
exposure resulting from its use. - ANS✅✅Regulatory toxicology
well graded A+
When considering the dose-response relationship for an essential substance______ -
ANS✅✅adverse responses increase in severity with increasing or decreasing dosages outside of
the homeostatic range.
T/F: Modern toxicology is concerned with the study of the adverse effects of chemicals on ancient
forms of life - ANS✅✅False
T/F. Modern toxicology studies embrace principles from such disciplines as biochemistry, botany,
chemistry, physiology, and physics. - ANS✅✅True
Knowledge of the toxicology of poisonous agents was published earliest in the _____ -
ANS✅✅Ebers papyrus
Paracelsus, a physician-alchemist, formulated many revolutionary views that remain integral to the
structure of toxicology, pharmacology, and therapeutics today. He focused on the primary toxic
agent as a chemical entity and articulated the dose-response relation. Describe 4 statements that
are attributable to Paracelsus - ANS✅✅1. Experimentation is essential in the examination of
responses to chemicals
2. One should make a distinction between the therapeutic and toxic properties of chemicals
3. These properties are sometimes but not always indistinguishable except by dose
4. One can ascertain a degree of specificity of chemicals and their therapeutic or toxic effects
Which modern toxicologist is credited with saying that "you can be a toxicologist in two easy lesions,
each of 10 years?" - ANS✅✅Arnold Lehman
T/F. Louis Lewin trained under Oswald Schmeideberg and published much of the early work on the
toxicity of narcotics, methanol, and chloroform - ANS✅✅True
, Harmful chemicals that are produced by living organisms - ANS✅✅Toxin
A term to denote any chemical that can
potentially produce harm - ANS✅✅toxicant
Xenobiotics - ANS✅✅means foreign to the body and can refer to any chemical that is not a natural
component of the body
Which physician is credited with being one of the first physicians to apply basic pharmacology and
toxicology principles to the practice of medicine, including
concepts of bioavailability and overdose. - ANS✅✅Hippocrates
This contains the recipes of more than 800 "medicinal" and poisonous preparations. It describes
poisons known at that time, including hemlock, later to be used as the state poison of the Greeks, as
well as opium, aconite (a Chinese arrow poison), and heavy metals such as lead, copper, and
antimony - ANS✅✅Ebers Papyrus
____may be very useful in
demonstrating that an adverse outcome
(e.g., cancer, birth defects) observed in
laboratory animals is directly relevant to
humans. - ANS✅✅Mechanistic toxicology
______Is concerned directly with toxicity testing,
which provides information for safety
evaluation and regulatory requirements. - ANS✅✅Descriptive toxicology
• Is concerned with deciding, whether a drug
or other chemical poses a sufficiently low
risk to be marketed for a stated purpose or
subsequent human or environmental
exposure resulting from its use. - ANS✅✅Regulatory toxicology
