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MPH 6011 Final Exam Questions with Correct Answers Latest Update

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MPH 6011 Final Exam Questions with Correct Answers Latest Update True or false: A retrospective cohort study is an observational study but a prospective cohort study is an intervention study. - Answers False What study designs are both analytic, observational studies? - Answers Retrospective and prospective cohort studies What is the measure of association if we start with a cohort free of disease and analysis is by cumulative incidence? - Answers relative risk What is the ratio of cumulative incidence rate in exposed compared to cumulative incidence rate in the unexposed? - Answers relative risk What is the measure of association if we start with a cohort free of disease and analysis is by incidence rates with person-time in the denominator? - Answers rate ratio In a cohort study, several design and implementation problems can impact the strength of the measure of association. Choose which of these problems below is least likely in a cohort study? a. information bias b. absence of temporality c. loss to follow-up d. none of the above - Answers b Among the items listed below, which design feature or bias is NOT similarly found in both case-control and cohort studies? a. both make comparisons between exposed and unexposed groups b. confounding c. both measure exposure before disease occurs d. both can have misclassification of exposure - Answers c Exposure is measured __________ disease occurrence in cohort studies. a. before b. after - Answers a In a cohort study, the association between smoking and coronary heart disease was investigated by selecting for study a group of 3000 smokers and 5000 non-smokers who were free of disease at baseline. Both groups were followed for the development of coronary heart disease. 84 smokers developed coronary heart disease and 87 non smokers did too. 4913 persons did not develop disease and did not smoke. The measure of association relating exposed to unexposed would be: - Answers (84/3000)/(87/5000) True or false: Attributable risk tells us how much disease can be prevented if exposure is removed from the population. - Answers True In a 20 year cohort study with 30 cases of heart disease in exposed group and 54,308 person years, while the unexposed group had 60 cases and 51,477 person-years. The measure of association showed 0.47. The best interpretation of this finding was: a. exposed group had a greater risk of heart disease than unexposed group b. unexposed group had reduced risk of heart disease compared to exposed group c. exposed group had a reduced risk of heart disease compared to the unexposed group - Answers c Which of the following is an advantage of cohort studies? a. can examine multiple outcomes from a single exposure b. can match on confounders c. can avoid recall bias d. can enroll cases at beginning of study - Answers a True or false: A case control study can be embedded within a cohort? - Answers True What are the two examples of case-control design embedded within a cohort? - Answers Nested case control and case-cohort What is the design feature unique to experimental studies? - Answers Randomization True or false: The purpose of randomization is to eliminate conscious bias by provider on patient selection for treatment group. - Answers True What are the two reasons why randomization is preferred to non-randomized studies? - Answers 1. eliminates conscious bias by provider on patient selection for treatment group 2. averages unknown confounders and makes groups similar The primary purpose of a double blind study is to: a. achieve comparability of treated and untreated subjects b. reduce efforts of sampling error c. avoid provider bias and participant bias d. avoid participant bias and increase recruitment - Answers c Randomized controlled trials do not include which design: a. randomization b. blinding c. factorial design d. odds ratio - Answers d The first element in developing a study protocol is: a. figuring out how to recruit patients b. planning statistical analysis

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EPID 7020 Midterm Study Questions with Correct Answers

True or False: When calculating the incidence rate of a disease, you exclude from the calculation
persons who had disease at the start of the risk period. - Answers True

Multiple Choice: When disease incidence and disease duration is stable, prevalence will..

A. Increase with increasing disease incidence and decrease with increasing disease duration.

B. Decrease with increasing disease incidence and increase with increasing disease duration.

C. Increase with increasing disease incidence and increase with increasing disease duration.

D. Increase with decreasing disease incidence and increase with decreasing disease duration. -
Answers C. Increase with increasing disease incidence and increase with increasing disease
duration.

Short Answer: Out of the four methods used to estimate incidence proportions which method
can not be used when follow up is incomplete? - Answers Incidence Density Method

Consider a study researching the flu was conducted with a sample size of 350 over a year.
During this study, 30% of the sample contracted the flu. What is the incidence rate of this study?
- Answers 0.3 cases of influenza per one year of person-time

Prevalence is influenced by:

a. disease incidence

b. study duration

c. disease risk

d. initial sample size - Answers a. disease incidence

True or False: In an open population no new members can be added in over time. - Answers
False

True or False: A closed population is a type of population where individuals can join or leave a
study throughout the time period that the study is ongoing. - Answers False

Short Answer: Why would an individual choose to measure the incidence proportion rather than
the incidence density? - Answers - easier to understand

- predicts individual risk

- understand cumulative frequency of disease occurrence when risk overtime is not uniform

Short Answer: What does it mean when we say "the Classic Life Table is just a special case of

, the Kaplan-Meier curve"? - Answers ????

Multiple Select: If the number of people entering a population is balanced by the number exiting
the population in any

period of time within levels of age, sex, and other determinants of risk, the population is ....

a) open

b) closed

c) steady - Answers a) open

c) steady

Short Answer: In a 4-year longitudinal study of cardiovascular disease among 8,000 adults, the
exact date of disease onset is not known. Instead, the researchers have yearly data on the
number of new cases for each year of follow-up. Additionally, some participants leave the study
for unknown reasons, and their data is censored. The researchers want to estimate the annual
probability of developing cardiovascular disease in this population.Which method should be
used for calculating incidence proportion and why? - Answers The method used should be the
Classic Life Table Approach because it doesn't require exact time of events, handles censored
observations, and can measure incidence proportion over long follow-up intervals

Short Answer: How does the use of aggregate data versus individual-level data in the incidence
density method, which estimates incidence proportion from incidence rate data, impact the
assumption of uniformity of losses? - Answers ???

True or False: An assumption for incidence proportion is that risk remains constant over the
follow-up period. - Answers True

True or False: The risk ratio and risk difference, when derived from incidence proportions, are
constrained to an asymmetric range between 0 and 1. - Answers False

True or False: If disease incidence is static, disease prevalence will increase as duration
decreases. - Answers False

True or False: The time-period that is captured by an exposure variable must include the time
immediately before the risk period. - Answers True

Multiple Choice: What does the term "available dose" refer to in exposure measurement?

a) The amount of exposure absorbed by the body

b) The concentration of an agent in the subject's external environment

c) The total duration of exposure

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