Case Study Latest 2025-2026 GRADED
A+ with Complete Solution
A ,28-year-old ,woman ,bleeds ,profusely ,following ,the ,birth ,of ,her ,first ,child. ,She ,has
,had ,a ,mild ,systemic ,bleeding ,tendency ,(following ,hemostatic ,challenges) ,throughout
,her ,life. ,- ,CORRECT ,ANSWER-vWF ,Disease
A ,40-year-old ,female ,with ,rheumatoid ,arthritis ,presents ,with ,her ,second ,deep-vein
,thrombosis. ,There ,is ,no ,family ,history ,of ,thrombosis. ,- ,CORRECT ,ANSWER-Lupus
,Anticoagulant
A ,25-year-old ,woman ,was ,admitted ,to ,the ,hospital ,with ,a ,pulmonary ,embolism ,after
,an ,overseas ,flight. ,Heparin ,and ,Coumadin ,were ,started ,immediately. ,Her ,baseline
,coagulation ,tests ,were ,all ,normal. ,Twenty-four ,hours ,later ,her ,coagulation ,tests ,were
,as ,follows: ,- ,CORRECT ,ANSWER-Antithrombin ,deficiency
An ,18-year-old ,male ,with ,known ,hemophilia ,A ,is ,seen ,in ,the ,emergency ,room ,for
,swelling ,and ,pain ,of ,the ,knees. ,He ,is ,given ,a ,dose ,of ,factor ,VIII ,concentrate
,calculated ,from ,his ,plasma ,volume ,and ,target ,factor ,VIII ,level. ,- ,CORRECT
,ANSWER-Specific ,factor ,VIII ,antibody ,or ,inhibitor
A ,previously ,healthy ,28-year-old ,female ,complains ,of ,bruising ,and ,red ,spots ,on ,her
,legs. ,- ,CORRECT ,ANSWER-idiopathic ,(immune) ,thrombocytopenic ,purpura ,(ITP)
A ,58-year-old ,male ,is ,admitted ,to ,the ,hospital ,with ,jaundice ,and ,nosebleeds. ,-
,CORRECT ,ANSWER-Bleeding ,secondary ,to ,liver ,disease
A ,69-year-old ,female ,is ,in ,the ,hospital ,being ,treated ,for ,recently ,diagnosed ,breast
,cancer. ,- ,CORRECT ,ANSWER-Pancytopenia ,secondary ,to ,cancer ,treatment
A ,30-year-old ,female ,complains ,of ,fatigues, ,weakness,bone ,pain ,and ,brusing. ,-
,CORRECT ,ANSWER-M3 ,acute ,myeloid ,leukemia ,with ,developing ,DIC
A ,50 ,year ,old ,male ,presents ,with ,weight ,loss, ,malaise, ,and ,tender, ,distendend
,abdomen. ,- ,CORRECT ,ANSWER-CML
A ,65 ,year ,old ,female ,complains ,of ,fatigue ,and ,increasing ,back ,pain. ,- ,CORRECT
,ANSWER-Multiple ,Myeloma
, What ,information ,is ,most ,diagnostic ,of ,the ,65 ,year ,old ,women ,with ,fatigue ,and ,back
,pain? ,- ,CORRECT ,ANSWER-Bone ,Marrow ,and ,SPE
Peripheral ,blood ,finding ,of ,the ,65 ,year ,old ,with ,fatigue ,and ,back ,pain? ,- ,CORRECT
,ANSWER-Pancytopenia
A ,32 ,year ,old ,male ,complained ,of ,fever ,and ,night ,sweats. ,Losing ,weight ,over ,the ,last
,few ,months, ,cervical ,node ,large ,and ,enlarged.
What ,are ,the ,cells ,seen? ,- ,CORRECT ,ANSWER-Hodgkins ,Disease ,(NSHD)
Reed-Sternberg ,Cells
An ,elderly ,infirm ,woman ,presents ,with ,shortness ,of ,breath, ,cough ,and ,fever. ,-
,CORRECT ,ANSWER-Bacterial ,infection, ,probably ,pneumococcal ,pneumonia
A ,19 ,year ,old ,male ,complains ,of ,severe ,fatigue, ,sore ,throat ,and ,swollen ,lymph
,nodes. ,- ,CORRECT ,ANSWER-Infectious ,Mononucleosis
A ,65 ,year ,old ,male ,is ,admitted ,to ,the ,hospital ,for ,a ,knee ,replacement. ,- ,CORRECT
,ANSWER-CLL
A ,22 ,year ,old ,white ,male ,with ,fever, ,sore ,throat ,and ,coughing. ,- ,CORRECT
,ANSWER-AML
An ,adult ,woman ,has ,a ,platelet ,count ,of ,6 ,x ,10^9L. ,All ,other ,hematology ,and ,routine
,coagulation ,has ,tests ,were ,normal. ,She ,has ,a ,platelet-associated ,IgG ,in ,her ,serum.
,What ,is ,most ,likely? ,- ,CORRECT ,ANSWER-ITP
A ,22 ,year ,old ,white ,male ,with ,fever, ,sore ,throat ,and ,coughing.
What ,tests ,should ,be ,performed? ,- ,CORRECT ,ANSWER--Cytochemical ,Staining
-Flow ,Cytometry ,
-Karyotyping
Case ,1
A ,28-year-old ,woman ,female ,bleeds ,profusely ,following ,the ,birth ,of ,her ,first ,child.
,She ,has ,had ,a ,mild ,systemic ,bleeding ,tendency ,(following ,hemostatic ,challenges)
,throughout ,her ,life.
Interpret ,the ,coagulation ,screening ,tests.
Tests ,to ,detect ,von ,Willebrand ,disease: ,- ,CORRECT ,ANSWER-APTT ,is ,slightly
,prolonged.
Tests ,to ,detect ,vWF ,disease.
A+ with Complete Solution
A ,28-year-old ,woman ,bleeds ,profusely ,following ,the ,birth ,of ,her ,first ,child. ,She ,has
,had ,a ,mild ,systemic ,bleeding ,tendency ,(following ,hemostatic ,challenges) ,throughout
,her ,life. ,- ,CORRECT ,ANSWER-vWF ,Disease
A ,40-year-old ,female ,with ,rheumatoid ,arthritis ,presents ,with ,her ,second ,deep-vein
,thrombosis. ,There ,is ,no ,family ,history ,of ,thrombosis. ,- ,CORRECT ,ANSWER-Lupus
,Anticoagulant
A ,25-year-old ,woman ,was ,admitted ,to ,the ,hospital ,with ,a ,pulmonary ,embolism ,after
,an ,overseas ,flight. ,Heparin ,and ,Coumadin ,were ,started ,immediately. ,Her ,baseline
,coagulation ,tests ,were ,all ,normal. ,Twenty-four ,hours ,later ,her ,coagulation ,tests ,were
,as ,follows: ,- ,CORRECT ,ANSWER-Antithrombin ,deficiency
An ,18-year-old ,male ,with ,known ,hemophilia ,A ,is ,seen ,in ,the ,emergency ,room ,for
,swelling ,and ,pain ,of ,the ,knees. ,He ,is ,given ,a ,dose ,of ,factor ,VIII ,concentrate
,calculated ,from ,his ,plasma ,volume ,and ,target ,factor ,VIII ,level. ,- ,CORRECT
,ANSWER-Specific ,factor ,VIII ,antibody ,or ,inhibitor
A ,previously ,healthy ,28-year-old ,female ,complains ,of ,bruising ,and ,red ,spots ,on ,her
,legs. ,- ,CORRECT ,ANSWER-idiopathic ,(immune) ,thrombocytopenic ,purpura ,(ITP)
A ,58-year-old ,male ,is ,admitted ,to ,the ,hospital ,with ,jaundice ,and ,nosebleeds. ,-
,CORRECT ,ANSWER-Bleeding ,secondary ,to ,liver ,disease
A ,69-year-old ,female ,is ,in ,the ,hospital ,being ,treated ,for ,recently ,diagnosed ,breast
,cancer. ,- ,CORRECT ,ANSWER-Pancytopenia ,secondary ,to ,cancer ,treatment
A ,30-year-old ,female ,complains ,of ,fatigues, ,weakness,bone ,pain ,and ,brusing. ,-
,CORRECT ,ANSWER-M3 ,acute ,myeloid ,leukemia ,with ,developing ,DIC
A ,50 ,year ,old ,male ,presents ,with ,weight ,loss, ,malaise, ,and ,tender, ,distendend
,abdomen. ,- ,CORRECT ,ANSWER-CML
A ,65 ,year ,old ,female ,complains ,of ,fatigue ,and ,increasing ,back ,pain. ,- ,CORRECT
,ANSWER-Multiple ,Myeloma
, What ,information ,is ,most ,diagnostic ,of ,the ,65 ,year ,old ,women ,with ,fatigue ,and ,back
,pain? ,- ,CORRECT ,ANSWER-Bone ,Marrow ,and ,SPE
Peripheral ,blood ,finding ,of ,the ,65 ,year ,old ,with ,fatigue ,and ,back ,pain? ,- ,CORRECT
,ANSWER-Pancytopenia
A ,32 ,year ,old ,male ,complained ,of ,fever ,and ,night ,sweats. ,Losing ,weight ,over ,the ,last
,few ,months, ,cervical ,node ,large ,and ,enlarged.
What ,are ,the ,cells ,seen? ,- ,CORRECT ,ANSWER-Hodgkins ,Disease ,(NSHD)
Reed-Sternberg ,Cells
An ,elderly ,infirm ,woman ,presents ,with ,shortness ,of ,breath, ,cough ,and ,fever. ,-
,CORRECT ,ANSWER-Bacterial ,infection, ,probably ,pneumococcal ,pneumonia
A ,19 ,year ,old ,male ,complains ,of ,severe ,fatigue, ,sore ,throat ,and ,swollen ,lymph
,nodes. ,- ,CORRECT ,ANSWER-Infectious ,Mononucleosis
A ,65 ,year ,old ,male ,is ,admitted ,to ,the ,hospital ,for ,a ,knee ,replacement. ,- ,CORRECT
,ANSWER-CLL
A ,22 ,year ,old ,white ,male ,with ,fever, ,sore ,throat ,and ,coughing. ,- ,CORRECT
,ANSWER-AML
An ,adult ,woman ,has ,a ,platelet ,count ,of ,6 ,x ,10^9L. ,All ,other ,hematology ,and ,routine
,coagulation ,has ,tests ,were ,normal. ,She ,has ,a ,platelet-associated ,IgG ,in ,her ,serum.
,What ,is ,most ,likely? ,- ,CORRECT ,ANSWER-ITP
A ,22 ,year ,old ,white ,male ,with ,fever, ,sore ,throat ,and ,coughing.
What ,tests ,should ,be ,performed? ,- ,CORRECT ,ANSWER--Cytochemical ,Staining
-Flow ,Cytometry ,
-Karyotyping
Case ,1
A ,28-year-old ,woman ,female ,bleeds ,profusely ,following ,the ,birth ,of ,her ,first ,child.
,She ,has ,had ,a ,mild ,systemic ,bleeding ,tendency ,(following ,hemostatic ,challenges)
,throughout ,her ,life.
Interpret ,the ,coagulation ,screening ,tests.
Tests ,to ,detect ,von ,Willebrand ,disease: ,- ,CORRECT ,ANSWER-APTT ,is ,slightly
,prolonged.
Tests ,to ,detect ,vWF ,disease.
