10/8/25, 7:25 AM PSY 627 Exam fully solved & updated 2025-2026(latest version verified for accuracy) (Questions + Answers) Solved 100% Correct!…
PSY 627 Exam fully solved & updated 2025-
2026(latest version verified for accuracy)
(Questions + Answers) Solved 100% Correct!!
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Terms in this set (44)
activates a receptor just as the natural
Agonist (direct)
neurotransmitter does
Blocks the neurotransmitter by binding to its receptor,
thereby preventing the natural neurotransmitter from
binding - but has no effect on the receptor.
If dopamine is being released, the affect would be to
Antagonist (direct antagonize (blocking the effect of the natural NT).
antagonist)
If the patient is taking an agonist and antagonist then
one will block the other - competition
If the antagonist is present it will compete with the
natural NT or another agonist drug.
A WEAKER effect than a full agonist. - Different partial
agonists have different "set points":
Some are more agonistic, others more antagonistic
Partial agonist
If you raise the dose, it won't make much difference
because the set points are built into the chemical
molecule of the drug (can't take partial agonists and
raise the dose to make a full agonist).
https://quizlet.com/1089404538/psy-627-exam-fully-solved-updated-2025-2026latest-version-verified-for-accuracy-questions-answers-solved-100-cor… 1/18
,10/8/25, 7:25 AM PSY 627 Exam fully solved & updated 2025-2026(latest version verified for accuracy) (Questions + Answers) Solved 100% Correct!…
how a drug is absorbed, distributed, metabolized, and
Pharmacokinetics
excreted.
A route of administration.
•via the gastrointestinal (GI) tract*
•Oral (PO)*: safest and easiest route
•The oral drug must pass through the stomach (acid,
enzymes) and into the small intestine
Enteral •The drug then enters the portal vein to the liver,
where it is metabolized (first-pass metabolism, "first-
pass effect")
*PO takes ~ 1-3 hours for 75% of the dose of most
psychoactive drugs to enter the blood, depending on
lipid (fat) solubility (has to be fatty enough to enter
into the neurons - can't be too fatty because water
and fat don't mix and it won't get far)
Avoids the GI tract and first-pass metabolism
Inhaled: to the lungs*
•Produces the fastest* drug effects (8-10 secs)
•Lungs have the largest surface area
Parenteral
•Avoids most of first-pass metabolism
•Blood goes from the lungs to the left side of the
heart and is quickly pumped out to the arterial system,
including the brain
•Smoking gets a drug to the brain quickly and is very
reinforcing*
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, 10/8/25, 7:25 AM PSY 627 Exam fully solved & updated 2025-2026(latest version verified for accuracy) (Questions + Answers) Solved 100% Correct!…
"Extensive" ("normal"), "intermediate" ("poor"), or "ultra-
fast" ("rapid") metabolizers
Individuals vary* in the amount of enzymes that
metabolize a given drug, due to genetic variations
Rapid metabolizer vs. slow
metabolizer
-A rapid metabolizer for one enzyme may not be
rapid for another enzyme
o DNA testing can identify specific variations in an
individual (rapid metabolizer, slow, etc.)
Most drug doses* are set for "extensive" ("normal")
What are most drug doses
metabolizers - the drug companies figured out what
set for in terms of
the average person needs based on average
metabolizers?
metabolism.
Transformation of a drug into compounds that are
easier to eliminate.
· Performed by enzymes (a protein, made by genes
making the enzyme) primarily in the liver and
intestine
Metabolism
o A drug is usually inactivated, easier to excrete
o A prodrug* is initially inactive but becomes active
when absorbed or metabolized (like vibanx? For
ADHD because it is intended to act the whole day.
Can only work when metabolized so can't be
snorted).
https://quizlet.com/1089404538/psy-627-exam-fully-solved-updated-2025-2026latest-version-verified-for-accuracy-questions-answers-solved-100-cor… 3/18
PSY 627 Exam fully solved & updated 2025-
2026(latest version verified for accuracy)
(Questions + Answers) Solved 100% Correct!!
Save
Terms in this set (44)
activates a receptor just as the natural
Agonist (direct)
neurotransmitter does
Blocks the neurotransmitter by binding to its receptor,
thereby preventing the natural neurotransmitter from
binding - but has no effect on the receptor.
If dopamine is being released, the affect would be to
Antagonist (direct antagonize (blocking the effect of the natural NT).
antagonist)
If the patient is taking an agonist and antagonist then
one will block the other - competition
If the antagonist is present it will compete with the
natural NT or another agonist drug.
A WEAKER effect than a full agonist. - Different partial
agonists have different "set points":
Some are more agonistic, others more antagonistic
Partial agonist
If you raise the dose, it won't make much difference
because the set points are built into the chemical
molecule of the drug (can't take partial agonists and
raise the dose to make a full agonist).
https://quizlet.com/1089404538/psy-627-exam-fully-solved-updated-2025-2026latest-version-verified-for-accuracy-questions-answers-solved-100-cor… 1/18
,10/8/25, 7:25 AM PSY 627 Exam fully solved & updated 2025-2026(latest version verified for accuracy) (Questions + Answers) Solved 100% Correct!…
how a drug is absorbed, distributed, metabolized, and
Pharmacokinetics
excreted.
A route of administration.
•via the gastrointestinal (GI) tract*
•Oral (PO)*: safest and easiest route
•The oral drug must pass through the stomach (acid,
enzymes) and into the small intestine
Enteral •The drug then enters the portal vein to the liver,
where it is metabolized (first-pass metabolism, "first-
pass effect")
*PO takes ~ 1-3 hours for 75% of the dose of most
psychoactive drugs to enter the blood, depending on
lipid (fat) solubility (has to be fatty enough to enter
into the neurons - can't be too fatty because water
and fat don't mix and it won't get far)
Avoids the GI tract and first-pass metabolism
Inhaled: to the lungs*
•Produces the fastest* drug effects (8-10 secs)
•Lungs have the largest surface area
Parenteral
•Avoids most of first-pass metabolism
•Blood goes from the lungs to the left side of the
heart and is quickly pumped out to the arterial system,
including the brain
•Smoking gets a drug to the brain quickly and is very
reinforcing*
https://quizlet.com/1089404538/psy-627-exam-fully-solved-updated-2025-2026latest-version-verified-for-accuracy-questions-answers-solved-100-cor… 2/18
, 10/8/25, 7:25 AM PSY 627 Exam fully solved & updated 2025-2026(latest version verified for accuracy) (Questions + Answers) Solved 100% Correct!…
"Extensive" ("normal"), "intermediate" ("poor"), or "ultra-
fast" ("rapid") metabolizers
Individuals vary* in the amount of enzymes that
metabolize a given drug, due to genetic variations
Rapid metabolizer vs. slow
metabolizer
-A rapid metabolizer for one enzyme may not be
rapid for another enzyme
o DNA testing can identify specific variations in an
individual (rapid metabolizer, slow, etc.)
Most drug doses* are set for "extensive" ("normal")
What are most drug doses
metabolizers - the drug companies figured out what
set for in terms of
the average person needs based on average
metabolizers?
metabolism.
Transformation of a drug into compounds that are
easier to eliminate.
· Performed by enzymes (a protein, made by genes
making the enzyme) primarily in the liver and
intestine
Metabolism
o A drug is usually inactivated, easier to excrete
o A prodrug* is initially inactive but becomes active
when absorbed or metabolized (like vibanx? For
ADHD because it is intended to act the whole day.
Can only work when metabolized so can't be
snorted).
https://quizlet.com/1089404538/psy-627-exam-fully-solved-updated-2025-2026latest-version-verified-for-accuracy-questions-answers-solved-100-cor… 3/18
