Chamberlain University
NR 546 / NR546
Week 5
Antidepressant Medications Table
Course: Advanced Pharmacology
, lOMoARcPSD|51648332
Antidepressant Medications
Indication, starting Half-life Notes/Notable side effects/Precautions
Name dose, target (T1/2)
symptoms, and CYP450
affected neurotransmitters enzyme
SSRIs
Citalopram • Target • Weak • Rare seizures, induction of mania, activation of
(Celexa) symptoms inhibitor suicidal ideation Sexual dysfunction
• Depressed mood of • Decreased appetite, n/d, constipation, dry mouth
• Anxiety CYP450 • Dose dependent insomnia, sedation,
• Panic attacks, 2D6 agitation, tremors, headache,dizzy
avoidant Metabolized by • Pt with bipolar or psychotic d/o may be
behavior, CYPf450 3A4 and more vulnerable to CNS-activating
reexperiencing, 2C19 actions of SSRIs
hyperarousal • Sweating
• Sleep Half-life • Bruising and rare bleeding
disturbance, 23-45 • Rare hyponatremia
insomnia and hour • Syndrome of inappropriate antidiuretic
hypersomnia Indication CYP450 hormone
• Depression •
• PMDD
• OCD
• Panic d/o
• GAD
• PTSD
• Social anxiety
d/o Neurotransmitter
• Serotoni
n
Escitalopram Target symptoms Half-life • Sexual dysfunction ED, delayed ejaculation,
(Lexapro) • Depressed mood 27-32 hours decreased sexual desire, anorgasmia
• Anxiety CYP450 • Decreased appetite, n/d, constipation, dry mouth
• Panic attacks, Substrate for • Insomnia and sedation, agitation, tremors,
, lOMoARcPSD|51648332
avoidant CYP450 and 3A4 headache, dizzy
behavior, No significant • Pt with bipolar or psychotic d/o may be
reexperiencing, actions on CYP450 more vulnerable to CNS-activating
hyperarousal enzymes actions of SSRIs
• Sleep • Sweating
disturbance, • Rare hyponatremia
insomnia and Syndrome of inappropriate antidiuretic hormone
hypersomnia secretion
• Rare seizures, induction of mania, activation of
Indication suicidal ideation
• MDD 12+
• GAD
• Panic d/o
• OCD
• PTSD
• Social anxiety d/o
• PMDD
Neurotransmitter
• Serotonin
NR 546 / NR546
Week 5
Antidepressant Medications Table
Course: Advanced Pharmacology
, lOMoARcPSD|51648332
Antidepressant Medications
Indication, starting Half-life Notes/Notable side effects/Precautions
Name dose, target (T1/2)
symptoms, and CYP450
affected neurotransmitters enzyme
SSRIs
Citalopram • Target • Weak • Rare seizures, induction of mania, activation of
(Celexa) symptoms inhibitor suicidal ideation Sexual dysfunction
• Depressed mood of • Decreased appetite, n/d, constipation, dry mouth
• Anxiety CYP450 • Dose dependent insomnia, sedation,
• Panic attacks, 2D6 agitation, tremors, headache,dizzy
avoidant Metabolized by • Pt with bipolar or psychotic d/o may be
behavior, CYPf450 3A4 and more vulnerable to CNS-activating
reexperiencing, 2C19 actions of SSRIs
hyperarousal • Sweating
• Sleep Half-life • Bruising and rare bleeding
disturbance, 23-45 • Rare hyponatremia
insomnia and hour • Syndrome of inappropriate antidiuretic
hypersomnia Indication CYP450 hormone
• Depression •
• PMDD
• OCD
• Panic d/o
• GAD
• PTSD
• Social anxiety
d/o Neurotransmitter
• Serotoni
n
Escitalopram Target symptoms Half-life • Sexual dysfunction ED, delayed ejaculation,
(Lexapro) • Depressed mood 27-32 hours decreased sexual desire, anorgasmia
• Anxiety CYP450 • Decreased appetite, n/d, constipation, dry mouth
• Panic attacks, Substrate for • Insomnia and sedation, agitation, tremors,
, lOMoARcPSD|51648332
avoidant CYP450 and 3A4 headache, dizzy
behavior, No significant • Pt with bipolar or psychotic d/o may be
reexperiencing, actions on CYP450 more vulnerable to CNS-activating
hyperarousal enzymes actions of SSRIs
• Sleep • Sweating
disturbance, • Rare hyponatremia
insomnia and Syndrome of inappropriate antidiuretic hormone
hypersomnia secretion
• Rare seizures, induction of mania, activation of
Indication suicidal ideation
• MDD 12+
• GAD
• Panic d/o
• OCD
• PTSD
• Social anxiety d/o
• PMDD
Neurotransmitter
• Serotonin
