Chamberlain University
NR 546 / NR546
Week 4
Anxiolytic Table
Course: Advanced Pharmacology
, lOMoARcPSD|51648332
Anxiolytic Medications
Drug Name/ Indication Associated Half-life (T1/2) Notable side effects
Medication list diagnosis and targeted Neurotransmitters Metabolism (CYP 450
class symptoms enzyme)
Gabapentin Partial seizures Binds to the alpha Half-Life Sedation, dizziness
Postherpetic neuralgia 2 delta subunit of 5-7 hrs. Ataxia, fatigue, nystagmus, tremor
Restless leg syndrome voltage-sensitive Metabolism Peripheral edema
Neuropathic pain/ calcium channels Does not metabolize Blurred vision
chronic pain but excreted intact Vomiting, dyspepsia, diarrhea, dry mouth,
Anxiety renally constipation, weight gain
Bipolar disorder Additional effects in children under 12:
hostility, emotional lability, hyperkinesia,
thought disorder, weight gain
Pregabalin Diabetic peripheral Binds to the alpha Half-Life Sedation, dizziness
neuropathy 2 delta subunit of 5-7 hours Ataxia, fatigue, tremor, dysarthria,
Postherpetic neuralgia voltage-sensitive Metabolism paresthesia, memory impairment,
Fibromyalgia calcium channels Pregabalin is not coordination abnormal, impaired
Neuropathic pain metabolized but attention, confusion, euphoric mood,
associated with spinal excreted intact irritability
cord injury renally Vomiting, dry mouth, constipation,
Partial onset seizures weight gain, increased appetite,
in adults and pediatric flatulence
patients Blurred vision, diplopia
Peripheral Peripheral Edema
neuropathic pain Libido decreased, erectile dysfunction
GAD
Panic disorder
Social anxiety disorder
Buspirone Major depressive Boost Half life Dry mouth, constipation, nausea, weight
disorder neurotransmitter Parent: 10-14 Hrs. loss, anorexia, myalgia
Seasonal affective norepinephrine/n Metabolite: 20- Insomnia, dizziness, headache, agitation,
disorder oradrenaline and 27Hrs. anxiety, tremor, abdominal pain, tinnitus
Nicotine addiction dopamine Metabolism Sweating
Bipolar depression CYP450 2D6 Rash
Attention deficit Blocks Hypertension
hyperactivity disorder norepinephrine
(ADHD) reuptake pump,
Sexual Dysfunction presumably
increasing
NR 546 / NR546
Week 4
Anxiolytic Table
Course: Advanced Pharmacology
, lOMoARcPSD|51648332
Anxiolytic Medications
Drug Name/ Indication Associated Half-life (T1/2) Notable side effects
Medication list diagnosis and targeted Neurotransmitters Metabolism (CYP 450
class symptoms enzyme)
Gabapentin Partial seizures Binds to the alpha Half-Life Sedation, dizziness
Postherpetic neuralgia 2 delta subunit of 5-7 hrs. Ataxia, fatigue, nystagmus, tremor
Restless leg syndrome voltage-sensitive Metabolism Peripheral edema
Neuropathic pain/ calcium channels Does not metabolize Blurred vision
chronic pain but excreted intact Vomiting, dyspepsia, diarrhea, dry mouth,
Anxiety renally constipation, weight gain
Bipolar disorder Additional effects in children under 12:
hostility, emotional lability, hyperkinesia,
thought disorder, weight gain
Pregabalin Diabetic peripheral Binds to the alpha Half-Life Sedation, dizziness
neuropathy 2 delta subunit of 5-7 hours Ataxia, fatigue, tremor, dysarthria,
Postherpetic neuralgia voltage-sensitive Metabolism paresthesia, memory impairment,
Fibromyalgia calcium channels Pregabalin is not coordination abnormal, impaired
Neuropathic pain metabolized but attention, confusion, euphoric mood,
associated with spinal excreted intact irritability
cord injury renally Vomiting, dry mouth, constipation,
Partial onset seizures weight gain, increased appetite,
in adults and pediatric flatulence
patients Blurred vision, diplopia
Peripheral Peripheral Edema
neuropathic pain Libido decreased, erectile dysfunction
GAD
Panic disorder
Social anxiety disorder
Buspirone Major depressive Boost Half life Dry mouth, constipation, nausea, weight
disorder neurotransmitter Parent: 10-14 Hrs. loss, anorexia, myalgia
Seasonal affective norepinephrine/n Metabolite: 20- Insomnia, dizziness, headache, agitation,
disorder oradrenaline and 27Hrs. anxiety, tremor, abdominal pain, tinnitus
Nicotine addiction dopamine Metabolism Sweating
Bipolar depression CYP450 2D6 Rash
Attention deficit Blocks Hypertension
hyperactivity disorder norepinephrine
(ADHD) reuptake pump,
Sexual Dysfunction presumably
increasing
