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Akif Uzman
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Jerry Johnson ss
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Joseph Eichberg ss
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William Widger ss
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Swarthmore College ss
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JOHN WILEY & SONS, INC
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, Cover Designer Madelyn Lesure
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Christiansen Cover Photos
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(Vitruvian Man): © Odysseus/Alamy and © Dennis Hallinan/Alamy
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Molecular structures clockwise from top: based on X-ray structures that were
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respectively determined by Richard Dickerson and Horace Drew, Caltech; Gerard Bunick,
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University of Tennessee; Thomas Steitz, Yale University; Alfonso Mondragón, Northwestern
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University; Venki Ramakrishnan, MRC Laboratory of Molecular Biology, Cambridge, U.K.;
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Andrew Leslie and John Walker, MRC Laboratoryof Molecular Biology, Cambridge, U.K.
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Founded in 1807, John Wiley & Sons, Inc. has been a valued source of knowledge and
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understanding for more than 200 years, helping people around the world meet their needs
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and fulfill their aspirations. Our company is built on a foundation of principles that include
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responsibility to the communities we serve andwhere we live and work. In 2008, we launched a
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Corporate Citizenship Initiative, a global effort to address the environmental, social,
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economic, and ethical challenges we face in our business. Among the issues we are addressing
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are carbon impact, paper specifications and procurement, ethical conduct within our business and
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among our vendors, and community and charitable support. For more information, please visit our
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website: www.wiley.com/go/citizenship.
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Copyright © 2012 ss ss John Wiley & Sons, Inc.
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All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or
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transmitted in any form or by any means, electronic, mechanical, photocopying, recording,
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scanning or otherwise, except as permitted under Sections 107 or 108 of the 1976 United
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States Copyright Act, without either the prior written permission of the Publisher, or
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authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center,
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Inc., 222 Rosewood Drive, Danvers, MA 01923, website www.copyright.com. Requests to
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the Publisher for permission should be addressed to thePermissions Department, John Wiley &
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Sons, Inc. 111 River Street, Hoboken, NJ 07030-5774, (201) 748-6011, fax (201) 748-6008, website
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http://www.wiley.com/go/permissions.
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To order books or for customer service, please call 1-800-CALL WILEY (225-5945).
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Student Companion (paperback)
ss ss ISBN-13 978-1-1182-1827-3
Printed in the United States of
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s s
F
s
U
s s
N
s
D A M
bs s s n s s s s
E
s
N
s s
T A L S
s s s s
O
s
F
Biochemistry
LIFE AT bn
THE ss
b s s n s s MOLECULARLEV b
n
EL ss
Voet Voet Pratt
F O U R T H E D I T I O N
Akif Uzman Jerry Johnson Joseph Eichberg William
bn bs s s n s s bn
bn WidgerDonald Voet
bn Judith G. Voet
bn Charlotte b n ss b n ss
,W.Pratt
s
,STUDENT COMPANION TO ACCOMPANY ss ss ss
FUNDAMENTALS OF ss
BIOCHEMISTRY
LIFE ATTHEMOLECULAR LEVEL
ss ss ss ss
Fourth Edition ss
Akif Uzman
ss
University of Houston ss ss
Jerry Johnson ss
University of Houston ss ss
Joseph Eichberg ss
University of Houston ss ss
William Widger ss
University of Houston ss ss
Donald Voet ss
University of Pennsylvania ss ss
Judith G. Voet ss ss
Swarthmore College ss
Charlotte W. Pratt ss ss
Seattle, Washington ss
JOHN WILEY & SONS, INC
ss ss ss ss
, Cover Designer Madelyn Lesure
ss ss ss
Cover Illustration Norm
ss ss ss
Christiansen Cover Photos
ss bn ss
(Vitruvian Man): © Odysseus/Alamy and © Dennis Hallinan/Alamy
ss ss ss ss ss ss ss
Molecular structures clockwise from top: based on X-ray structures that were
s s s s s s s s s s s s s s s s s s s s
respectively determined by Richard Dickerson and Horace Drew, Caltech; Gerard Bunick,
s s ss ss ss ss ss ss ss ss ss ss
University of Tennessee; Thomas Steitz, Yale University; Alfonso Mondragón, Northwestern
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University; Venki Ramakrishnan, MRC Laboratory of Molecular Biology, Cambridge, U.K.;
ss ss ss ss ss ss ss ss ss ss
Andrew Leslie and John Walker, MRC Laboratoryof Molecular Biology, Cambridge, U.K.
ss ss ss ss ss ss ss ss ss ss ss
Founded in 1807, John Wiley & Sons, Inc. has been a valued source of knowledge and
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
understanding for more than 200 years, helping people around the world meet their needs
ss ss s s s s s s s s s s s s s s s s s s s s s s s s
and fulfill their aspirations. Our company is built on a foundation of principles that include
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responsibility to the communities we serve andwhere we live and work. In 2008, we launched a
ss ss ss s s ss ss ss ss ss ss ss ss ss ss ss ss
Corporate Citizenship Initiative, a global effort to address the environmental, social,
ss ss s s s s s s s s s s s s s s s s s s
economic, and ethical challenges we face in our business. Among the issues we are addressing
s s s s s s s s s s ss ss ss ss ss ss ss ss ss ss
are carbon impact, paper specifications and procurement, ethical conduct within our business and
ss ss ss ss ss ss s s ss ss ss ss ss ss
among our vendors, and community and charitable support. For more information, please visit our
ss ss ss ss ss ss s s s s ss ss ss ss ss ss
website: www.wiley.com/go/citizenship.
ss ss
Copyright © 2012 ss ss John Wiley & Sons, Inc.
ss ss ss ss
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or
ss ss ss ss s s ss ss s s ss ss ss ss ss ss ss ss
transmitted in any form or by any means, electronic, mechanical, photocopying, recording,
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scanning or otherwise, except as permitted under Sections 107 or 108 of the 1976 United
s s ss s s s s s s s s s s s s s s s s s s s s s s s s s s
States Copyright Act, without either the prior written permission of the Publisher, or
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authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center,
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Inc., 222 Rosewood Drive, Danvers, MA 01923, website www.copyright.com. Requests to
ss s s ss ss s s s s s s s s s s s s s s
the Publisher for permission should be addressed to thePermissions Department, John Wiley &
s s s s s s s s s s ss ss ss ss ss ss ss ss
Sons, Inc. 111 River Street, Hoboken, NJ 07030-5774, (201) 748-6011, fax (201) 748-6008, website
ss ss ss ss ss ss ss s s ss ss ss ss ss ss
http://www.wiley.com/go/permissions.
ss
To order books or for customer service, please call 1-800-CALL WILEY (225-5945).
ss ss ss ss ss ss ss ss ss ss ss
Student Companion (paperback)
ss ss ISBN-13 978-1-1182-1827-3
Printed in the United States of
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ss America 10 9 8 7 6 5 4 3 2 bn s s s s s s s s ss
ss 1
