Nagelhout Pharm 2 Exam 1 Questions and Answers (Most Recent Version, Complete Study Material)

Nagelhout Pharm 2 Exam 1 Questions
and Answers (Most Recent Version,
Complete Study Material)
The only depolarizing muscle relaxant in clinical use is: -
Correct Answers ✅-Succinylcholine (Anectine)
-Ultra short acting


Short-Acting Non-Depolarizing Blocker - Correct Answers
✅-Mivacurium


Intermediate-acting non-depolarizing blockers - Correct
Answers ✅Atracurium
Cisatracurium
Rocuronium
Vecuronium


Long-Acting Non-Depolarizing Blocker - Correct Answers
✅pancuronium


How is acetylcholine synthesized? Metabolized by?
Metabolites? - Correct Answers ✅-Synthesized in
presynaptic nerve terminal by N-acetyltransferase, combines
acetate and choline
-Metabolized acetylcholinesterase via rapid hydrolysis into
choline and acetic acid
-Choline re-enters the presynaptic terminal and used to make
more Ach

, Nagelhout Pharm 2 Exam 1 Questions
and Answers (Most Recent Version,
Complete Study Material)

Single twitch test - Correct Answers ✅-A single
supramaximal electrical stimulus ranging from 0.1-1.0 HZ
-Requires baseline before drug administration
-Only tells you 100% paralyzed (no twitch) or <100% (1
twitch)


Train of Four Test - Correct Answers ✅-A series of 4
twitches at 2 Hz every 0.5 sec for 2 seconds
-Reflects blockade from 70-100%; useful during onset,
maintenance, and emergence
-TOFR compares T4 to T1


Double Burst Stimulation - Correct Answers ✅Two short
bursts of tetanus (2-4 pulses at 50 Hz) separated by 0.75sec.
- May be better at detecting fade than TOF (more Hz)


Tetanus Test - Correct Answers ✅Generally, consists of
rapid delivery of a 30, 50, or 100 Hz stimulus for 5 seconds.


*Should be used sparingly for deep block assessment,
painful.*