NEUROLOGICAL BASIS OF SUD + PHARMACOLOGY
2025/2026 WITH 100% ACCURATE ANSWERS
1) What is the primitive brain (old)
2) What is the neocortex brain (new)
3) What is “stronger” / harder to override
4) Which one is the primary pleasure / reward system
5) Which one has strong learning paths? How do they react to change? -CORRECT ANSWERS1) Primitive
(old) brain
Primary pleasure/reward systems
Strong learning paths formed that are resistant to change
Irrational, instinctual, emotional
2) Rational, logical, thinking
3) Primitive is stronger / more powerful
4) Primitive
5) Primitive; resistant to change
1) What is the motivated adaptive behaviour
2) Explain classical conditioning’s role in this -CORRECT ANSWERS1) Process of learning/adapting to
maximize access to resources —> survival advantage
Survival of the fittest
2) Cues predict valuable resources
, 1) Dopamine: Novelty (new) ___ , makes you ___ behaviours, reinforces ___
2) Glutamate: Excitatory. ___ neuronal ___ via (___/___), directs ___ - making
3) GABA: Inhibitory, What does it do to a) glutamate b) DA-CORRECT ANSWERS1) Novelty detection,
approach behaviours, reinforces learning
2) Builds neuronal pathways via NMDA/AMPA, directs choice-naking
3) a) Can oppose glutamate; b) Can activate DA
Physiological Mechanisms of Enduring Neuroplasticity
1) Dopamine release promotes the release of what?
The answer to #1 binds to NMDA and AMPA receptors…
2) What do NMDA receptors do
3) What do AMPA receptors do
4) Repeated dopamine and ___ (Q1) activation leads to enduring changes which are ___ ____ ____
-CORRECT ANSWERS1) Glutamate
2) NMDA = Memory encoding, long term potentiation
3) AMPA = Memory retrieval
4) DA + glutamate = enduring changes = stroing learning pathways
Pathological Dysregulation with Acute & Chronic Substance Use
ACUTE/INTERMITTENT USE
2025/2026 WITH 100% ACCURATE ANSWERS
1) What is the primitive brain (old)
2) What is the neocortex brain (new)
3) What is “stronger” / harder to override
4) Which one is the primary pleasure / reward system
5) Which one has strong learning paths? How do they react to change? -CORRECT ANSWERS1) Primitive
(old) brain
Primary pleasure/reward systems
Strong learning paths formed that are resistant to change
Irrational, instinctual, emotional
2) Rational, logical, thinking
3) Primitive is stronger / more powerful
4) Primitive
5) Primitive; resistant to change
1) What is the motivated adaptive behaviour
2) Explain classical conditioning’s role in this -CORRECT ANSWERS1) Process of learning/adapting to
maximize access to resources —> survival advantage
Survival of the fittest
2) Cues predict valuable resources
, 1) Dopamine: Novelty (new) ___ , makes you ___ behaviours, reinforces ___
2) Glutamate: Excitatory. ___ neuronal ___ via (___/___), directs ___ - making
3) GABA: Inhibitory, What does it do to a) glutamate b) DA-CORRECT ANSWERS1) Novelty detection,
approach behaviours, reinforces learning
2) Builds neuronal pathways via NMDA/AMPA, directs choice-naking
3) a) Can oppose glutamate; b) Can activate DA
Physiological Mechanisms of Enduring Neuroplasticity
1) Dopamine release promotes the release of what?
The answer to #1 binds to NMDA and AMPA receptors…
2) What do NMDA receptors do
3) What do AMPA receptors do
4) Repeated dopamine and ___ (Q1) activation leads to enduring changes which are ___ ____ ____
-CORRECT ANSWERS1) Glutamate
2) NMDA = Memory encoding, long term potentiation
3) AMPA = Memory retrieval
4) DA + glutamate = enduring changes = stroing learning pathways
Pathological Dysregulation with Acute & Chronic Substance Use
ACUTE/INTERMITTENT USE
