CANC 380 FINAL EXAM 2025
QUESTIONS WITH COMPLETE
SOLUTIONS!!
Oncogene
of MMPs cell
, Don't know?
2 of 313
Term
What is the risk of cancer in a tissue determined by?
Give this one a try later!
Breakthroughs are often reported using incomplete information
Drugs need to be deemed safe before they can be used for the public
Lifetime number of stem cell divisions in the tissue - replication or repair
errors
External environmental factors
VEGF increases vascular permeability - facilitates tumour cell intravasation
High VEGF concentrations upregulates secretion of proteases that degrades the
basement membrane of endothelial cells
Random genetic mutations
Inherited genetic mutations
Inherited epigenetic mutations
Genotoxic stress
Don't know?
3 of 313
,Term
What cells of a tumour are subject to hypoxia?
Give this one a try later!
Surface cells near nutrient source Central core exposed to oxygen
Inner layers furthest from Outer layers closest to blood
oxygen supply vessels
Don't know?
4 of 313
Definition
Affect other immune cells in surround lymphoid tissue and modulate
myeloid cell activity
Don't infiltrate themselves
Give this one a try later!
How is E cadherin affected by
How do Bregs affect the TME?
hypoxia?
What do adipocytes do in terms of
What do CD8+ T cells require?
cancer?
, Don't know?
5 of 313
Definition
1. Random mutation due to error or exposure to genotoxic agent
2. If it's a driver mutation, clonal expansion will ensue
3. Genomic instability of clones increases frequency of mutation ->
sub clones
4. Most sub clones won't survive but sometimes will get a second
driver mutation and progeny will become pre-dominant
subpopulation within tumour (selective sweep)
5. Sub-clone dominates until newly generated sub-clone
outcompetes
Give this one a try later!
What are the steps involved when
What are the steps of clonal
pVHL binds to HIF-1 alpha to trigger
evolution?
degradation?
What are therapies that target the
What is the seed and soil theory?
TME?
Don't know?
6 of 313
Definition
QUESTIONS WITH COMPLETE
SOLUTIONS!!
Oncogene
of MMPs cell
, Don't know?
2 of 313
Term
What is the risk of cancer in a tissue determined by?
Give this one a try later!
Breakthroughs are often reported using incomplete information
Drugs need to be deemed safe before they can be used for the public
Lifetime number of stem cell divisions in the tissue - replication or repair
errors
External environmental factors
VEGF increases vascular permeability - facilitates tumour cell intravasation
High VEGF concentrations upregulates secretion of proteases that degrades the
basement membrane of endothelial cells
Random genetic mutations
Inherited genetic mutations
Inherited epigenetic mutations
Genotoxic stress
Don't know?
3 of 313
,Term
What cells of a tumour are subject to hypoxia?
Give this one a try later!
Surface cells near nutrient source Central core exposed to oxygen
Inner layers furthest from Outer layers closest to blood
oxygen supply vessels
Don't know?
4 of 313
Definition
Affect other immune cells in surround lymphoid tissue and modulate
myeloid cell activity
Don't infiltrate themselves
Give this one a try later!
How is E cadherin affected by
How do Bregs affect the TME?
hypoxia?
What do adipocytes do in terms of
What do CD8+ T cells require?
cancer?
, Don't know?
5 of 313
Definition
1. Random mutation due to error or exposure to genotoxic agent
2. If it's a driver mutation, clonal expansion will ensue
3. Genomic instability of clones increases frequency of mutation ->
sub clones
4. Most sub clones won't survive but sometimes will get a second
driver mutation and progeny will become pre-dominant
subpopulation within tumour (selective sweep)
5. Sub-clone dominates until newly generated sub-clone
outcompetes
Give this one a try later!
What are the steps involved when
What are the steps of clonal
pVHL binds to HIF-1 alpha to trigger
evolution?
degradation?
What are therapies that target the
What is the seed and soil theory?
TME?
Don't know?
6 of 313
Definition
