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2025 HESI A2 Anatomy & Physiology Practice Questions | Elsevier Prep with Verified Answers

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This 2025 HESI A2 Anatomy & Physiology Practice Question Bank (Elsevier-based) is a complete study resource for students preparing for the HESI Admission Assessment (A2) Exam. It includes a wide variety of exam-style practice questions with verified answers, designed to mirror the official A2 exam format. Content covers all essential anatomy and physiology topics, including cells, tissues, integumentary, skeletal, muscular, nervous, cardiovascular, respiratory, digestive, urinary, endocrine, and reproductive systems. Each question is paired with a clear answer explanation, making it easier to understand key concepts and improve retention. Perfect for nursing school applicants and pre-health students, this HESI A2 A&P practice guide helps strengthen test-taking skills, save study time, and boost confidence before exam day. Whether used for structured prep or last-minute review, this resource ensures you are fully prepared to succeed on the 2025 HESI A2 Exam.

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Elsevier Hesi A2 Anatomy and
Physiology Practice Questions
with Answers



In which of the following locations would the urinary bladder and
internal reproductive organs be found?

1. Thoracic cavity

2.
Mediastinum

3.
Abdominal cavity

4.
Pelvic cavity
- ANS - 4.
Pelvic cavity

Which tissue serves as the framework of the body by providing support
and structure for the organs?

1.
Epithelial
G6`
2.
Connective

3.
Nervous

4.
Muscle
- ANS - 2.
Connective

What are the glands of skin that produce a thin, watery secretion?


1.

,Sebaceous glands

2.
Eccrine glands

3.
Apocrine glands

4.
Endocrine glands
- ANS - 2.
Eccrine glands

You have been given a sample of tissue that has open spaces partially
filled by an assemblage of needle-like structures. What is the tissue?


1.
Spongy bone

2.
Compact bone

3.
Cartilage

4.
Adipose tissue
- ANS - 1.
Spongy bone

Which mineral is responsible for regulating fluid in the body?


1.
Chloride

2.
Sodium

3.
Calcium

4.
Magnesium
- ANS - 2.
Sodium

All actions of the nervous system depend on the transmission of nerve
impulses over which of the following?

,1.
Neuroglia

2.
Efferent pathways

3.
Afferent pathways

4.
Neurons
- ANS - 4.
Neurons

Which leukocytes are correctly matched with their function or description?
(Select all that apply.)


1.
Monocytes—become macrophages

2.
Basophils—the most common type of WBC

3.
Lymphocytes—important in immune response

4.
Neutrophils—phagocytize microorganisms
- ANS - 1, 3, and 4

Which of the following is the blood vessel where exchanges take place
between blood and the cells of the body?


1.
Artery

2.
Vein

3.
Capillary
4.
Arteriole
- ANS - 3.
Capillary

, In order for inhalation to occur, what must happen?


1.
Contraction of the diaphragm, which decreases the volume of the chest
cavity and draws air into the lungs
2.
Contraction of the diaphragm, which enlarges the chest cavity and
draws air into the lungs
3.
Recoil of the lungs as the respiratory muscles contract and the thorax
decreases in size
4.
Recoil of the lungs as the respiratory muscles relax and the thorax
decreases in size
- ANS - 2.
Contraction of the diaphragm, which enlarges the chest cavity and
draws air into the lungs

Which are the functional units of the kidney?


1.
Ureters

2.
Glomeruli

3.
Nephrons

4.
Renal capsules
- ANS - 3.
Nephrons

What separates the thoracic cavity from the abdominal cavity?


1.
Diaphragm

2.
Mediastinum

3.

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