9/22/25, 8:14 AM Advanced Pathophysiology UTMB 5355 EXAM 2: Questions and Answers (Verified Answers) (Latest Update 2025) UPDATE!! Flas…
Advanced Pathophysiology UTMB 5355 EXAM 2:
Questions and Answers (Verified Answers) (Latest
Update 2025) UPDATE!!
Save
Terms in this set (123)
cancer causing genes, promote uncontrolled growth
Oncogenes
of cells
Proto-oncogenes promote normal cell growth factor and division
If proto-oncogenes are Oncogenes
mutated the become -
Tumor Supressor Genes Antioncogenes
(TSGs) are
antioncogenes inhibit tumor progression & prevent mutations
Cancer develops with oncogenes, tumor suppressor genes
increase in - and decrease
in -
What are the 2 main types Gatekeepers & Caretakers
of Tumor Suppressor
Genes?
encode proteins that inhibit growth, prevent and
tumor suppressor genes repair mutations but if mutated will increase cancer
risk
https://quizlet.com/1080308920/advanced-pathophysiology-utmb-5355-exam-2-questions-and-answers-verified-answers-latest-update-2025-update-fla… 1/8
, 9/22/25, 8:14 AM Advanced Pathophysiology UTMB 5355 EXAM 2: Questions and Answers (Verified Answers) (Latest Update 2025) UPDATE!! Flas…
regulate cell proliferation, cell type specific, normally
Gatekeeper prevent uncontrolled growth and potential
progression of cancer
suppress gene mutations, repair DNA, if not
Caretaker
functioning correctly mutation can occur
How does chronic Inflammation increases free radicals and reactive
inflammation cause oxygen species which promote mutation
cancer?
interfere with insulin Pro-inflammatory cytokines
signaling leading to insulin
resistance in stress,
obesity, and Type 2
Diabetes.
tumor suppressor gene, if lost due to mutation cells
TP53 gene escape apoptosis and can divide indefinitely
increasing risk of cancer
tumor necrosis factor is _ pro-inflammatory, may be related to carcinogenesis
cytokine
1)cell survival
2)cell proliferation
4 functions of TNF
3) cell differentiation
4)cell death
CA therapy in relation to Modulation of TNF/receptors
TNF
not used to diagnose, but can be useful in
tumor markers surveillance of cancers or after cancer treatments,
elevated in some cancers
tumor markers are benign & malignant cells, increased levels seen in
produced by both cancerous/noncancerous tumors
tumor markers include hormones, enzymes, genes, antigens and antibodies
CA19-9 pancreatic cancer
https://quizlet.com/1080308920/advanced-pathophysiology-utmb-5355-exam-2-questions-and-answers-verified-answers-latest-update-2025-update-fla… 2/8
Advanced Pathophysiology UTMB 5355 EXAM 2:
Questions and Answers (Verified Answers) (Latest
Update 2025) UPDATE!!
Save
Terms in this set (123)
cancer causing genes, promote uncontrolled growth
Oncogenes
of cells
Proto-oncogenes promote normal cell growth factor and division
If proto-oncogenes are Oncogenes
mutated the become -
Tumor Supressor Genes Antioncogenes
(TSGs) are
antioncogenes inhibit tumor progression & prevent mutations
Cancer develops with oncogenes, tumor suppressor genes
increase in - and decrease
in -
What are the 2 main types Gatekeepers & Caretakers
of Tumor Suppressor
Genes?
encode proteins that inhibit growth, prevent and
tumor suppressor genes repair mutations but if mutated will increase cancer
risk
https://quizlet.com/1080308920/advanced-pathophysiology-utmb-5355-exam-2-questions-and-answers-verified-answers-latest-update-2025-update-fla… 1/8
, 9/22/25, 8:14 AM Advanced Pathophysiology UTMB 5355 EXAM 2: Questions and Answers (Verified Answers) (Latest Update 2025) UPDATE!! Flas…
regulate cell proliferation, cell type specific, normally
Gatekeeper prevent uncontrolled growth and potential
progression of cancer
suppress gene mutations, repair DNA, if not
Caretaker
functioning correctly mutation can occur
How does chronic Inflammation increases free radicals and reactive
inflammation cause oxygen species which promote mutation
cancer?
interfere with insulin Pro-inflammatory cytokines
signaling leading to insulin
resistance in stress,
obesity, and Type 2
Diabetes.
tumor suppressor gene, if lost due to mutation cells
TP53 gene escape apoptosis and can divide indefinitely
increasing risk of cancer
tumor necrosis factor is _ pro-inflammatory, may be related to carcinogenesis
cytokine
1)cell survival
2)cell proliferation
4 functions of TNF
3) cell differentiation
4)cell death
CA therapy in relation to Modulation of TNF/receptors
TNF
not used to diagnose, but can be useful in
tumor markers surveillance of cancers or after cancer treatments,
elevated in some cancers
tumor markers are benign & malignant cells, increased levels seen in
produced by both cancerous/noncancerous tumors
tumor markers include hormones, enzymes, genes, antigens and antibodies
CA19-9 pancreatic cancer
https://quizlet.com/1080308920/advanced-pathophysiology-utmb-5355-exam-2-questions-and-answers-verified-answers-latest-update-2025-update-fla… 2/8
