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MMSC 433 exam 1 Questions with 100% Verified
Answers UPDATED!!!
iron absorption - ANSWER -ferric iron is taken in from diet
-ferric iron is reduced by duodenal cytochrome B to become
ferrous iron
-ferrous iron is absorbed into enterocytes by DMT 1
-absorbed iron is stored as ferritin, or sent into portal hepatic
circulation and carried by transferrin to developing RBCs
transferrin - ANSWER plasma carrier protein for ferrous iron
high iron level regulation - ANSWER -hepcidin is released from
hepatocytes
-ferroportin is inactivated, leading to decreased iron being
transported into circulation
low iron level regulation - ANSWER -hepcidin is down regulated
by hepatocytes
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-ferroportin becomes activated and transports iron out of the
enterocytes and into circulation
dietary iron sources - ANSWER red meat, legumes, dark leafy
vegetables, whole grains
ferrous iron - ANSWER the form of iron that is able to be utilized
in the body for developing red cells
prussian blue stain - ANSWER stain that is used to identify iron
in tissues and bone marrow
thomas plot - ANSWER a chart that is used to compare soluble
transferrin receptors/ log ferritin to hemoglobin concentration
of reticulocytes to identify the iron status of the patient
-iron status is used to correlate to certain diseases/ anemias
stage 1 iron deficiency (progressive loss of storage iron) -
ANSWER -asymptomatic
-RBCs develop normally
-*serum ferritin low*
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stage 2 iron deficiency (exhaustion of iron storage pool) -
ANSWER -subclinical symptoms
-hemoglobin in retics is decreased, *hemogram appears normal
still*
-iron deficiency erythropoiesis is occurring
-hepcidin decreased
-serum iron and ferritin decreased
-RDW, TIBC and sTRs increased
-prussian blue stain of BM is negative for iron
stage 3 iron deficiency (frank anemia) - ANSWER -patient
exhibits fatigue, weakness, pallor, glossitis, koilonychia and pica
-*H/H decreased*
-*hypochromic/ microcytic anemia*
-FEP, TIBC and sTR increased
-ferritin, hepcidin and serum iron decreased
sideroblastic anemia - ANSWER -iron deposits in the
mitochondria of erythroblast cells in the bone marrow interfere
with biosynthesis of heme
-caused by genetic inheritance of drugs/ bone marrow toxins
(*lead*, antibiotics, chemotherapeutics)
MMSC 433 exam 1 Questions with 100% Verified
Answers UPDATED!!!
iron absorption - ANSWER -ferric iron is taken in from diet
-ferric iron is reduced by duodenal cytochrome B to become
ferrous iron
-ferrous iron is absorbed into enterocytes by DMT 1
-absorbed iron is stored as ferritin, or sent into portal hepatic
circulation and carried by transferrin to developing RBCs
transferrin - ANSWER plasma carrier protein for ferrous iron
high iron level regulation - ANSWER -hepcidin is released from
hepatocytes
-ferroportin is inactivated, leading to decreased iron being
transported into circulation
low iron level regulation - ANSWER -hepcidin is down regulated
by hepatocytes
,2|Page
-ferroportin becomes activated and transports iron out of the
enterocytes and into circulation
dietary iron sources - ANSWER red meat, legumes, dark leafy
vegetables, whole grains
ferrous iron - ANSWER the form of iron that is able to be utilized
in the body for developing red cells
prussian blue stain - ANSWER stain that is used to identify iron
in tissues and bone marrow
thomas plot - ANSWER a chart that is used to compare soluble
transferrin receptors/ log ferritin to hemoglobin concentration
of reticulocytes to identify the iron status of the patient
-iron status is used to correlate to certain diseases/ anemias
stage 1 iron deficiency (progressive loss of storage iron) -
ANSWER -asymptomatic
-RBCs develop normally
-*serum ferritin low*
, 3|Page
stage 2 iron deficiency (exhaustion of iron storage pool) -
ANSWER -subclinical symptoms
-hemoglobin in retics is decreased, *hemogram appears normal
still*
-iron deficiency erythropoiesis is occurring
-hepcidin decreased
-serum iron and ferritin decreased
-RDW, TIBC and sTRs increased
-prussian blue stain of BM is negative for iron
stage 3 iron deficiency (frank anemia) - ANSWER -patient
exhibits fatigue, weakness, pallor, glossitis, koilonychia and pica
-*H/H decreased*
-*hypochromic/ microcytic anemia*
-FEP, TIBC and sTR increased
-ferritin, hepcidin and serum iron decreased
sideroblastic anemia - ANSWER -iron deposits in the
mitochondria of erythroblast cells in the bone marrow interfere
with biosynthesis of heme
-caused by genetic inheritance of drugs/ bone marrow toxins
(*lead*, antibiotics, chemotherapeutics)
