Pharm. Ch 1-4, 6
A client is receiving 250 mg of a drug that has a half-life of 12 hours. How much drug would
remain after 36 hours?
31 mg
A nurse is caring for a client who has just been prescribed a loading dose of a drug. The nurse
should explain what rationale to the client for administering a loading dose?
"We want to make sure you get the benefits of the drug as quickly as possible."
The nurse understands that the dosage recommended by drug manufacturers is based on an
individual weighing:
150 lb (68 kg).
A client will soon be discharged home from the hospital after a successful coronary artery
bypass graft (CABG). During client education about drug regimen, the nurse should prioritize
teaching about:
potential adverse effects of the drugs that the client will be taking.
We have an expert-written solution to this problem!
Drugs undergo biotransformation in the liver or gastrointestinal track. What benefit is produced
when the drugs become water soluable (hydrophilic)?
The drugs can be excreted through the kidneys.
Why is it important for the nurse to obtain baseline information from a client, such as a drug
profile, an accurate history of the client's usual abilities, and changes in abilities or health
status?
To determine any new signs and symptoms in the client that could be related to drug therapy
We have an expert-written solution to this problem!
A nurse is aware that older adults tend to have a significantly decreased rate of hepatic blood
flow compared with younger adults. What effect is this likely to have on pharmacokinetics and
pharmacodynamics in an older adult?
Drug clearance is likely to be slower.
,We have an expert-written solution to this problem!
Drugs injected intravenously (IV) reach their full strength in which timeframe?
Immediately
Drug excretion occurs mainly in which organ?
kidneys
A client, prescribed a drug that has an exceptionally narrow margin of safety, should be
educated about the need for what intervention?
serum drug level monitoring
Which factor accounts for the increased risk for drug reactions among clients aged 65 years and
older?
physiologic changes affecting all pharmacokinetic processes
We have an expert-written solution to this problem!
A 72-year-old man with pain issues is being given a drug by the intramuscular route. His serum
blood level concentrations have been erratic. The nurse suspects that this may be due to
decreased blood flow to tissues and muscles.
We have an expert-written solution to this problem!
A client has been diagnosed with cardiovascular disorder. The client is age 68; suffers from
intermittent joint pain and is under drug therapy; eats meat, salads, and fruits; prefers alternative
herb medications along with drug therapy; sometimes smokes; he lives alone and is looked after
by a caregiver. Which item of information has the greatest implication for planning his drug
therapy?
prefers alternative herb medications
The nurse is explaining the pharmacokinetics of a drug being administered to a client. What is
meant by the term "pharmakokinetics?"
actions of drugs
What is the most frequently used drug administration route in clinical practice?
oral
, With buccal medications, what factor affects absorption?
integrity of the mucous membranes
The nurse knows that a client is at high risk for developing drug tolerance because the client will
be taking which drug for a long period of time?
Hydromorphone (Dilaudid) for pain
When researching information about a drug, the nurse finds that the drug tightly binds to protein.
The nurse would interpret this to mean that the drug will:
have a long duration of action.
A client with complex health needs takes a large number of medications. In order to reduce the
likelihood of drug-food interactions, the nurse should encourage the client to:
avoid drinking grapefruit juice.
What drug administration route should be used to assure the best bioavailability as any
particular drug?
intravenous
We have an expert-written solution to this problem!
An experienced nurse has observed that female clients sometimes experience a drug's effects
for a longer time than male clients of similar age and size. The nurse should attribute this to
what factor?
Women have more fat cells so drugs depositing in fat will have a prolonged effect.
We have an expert-written solution to this problem!
A client is taking low-dose aspirin daily for her heart. The client is not receiving all the dosage of
the aspirin that is being ingested because of:
first-pass effect.
For what reason is the creatinine level alone not a good indicator of renal function in the older
adult?
There is a decline in overall muscle mass, which produces a lower creatinine level.
A client is receiving 250 mg of a drug that has a half-life of 12 hours. How much drug would
remain after 36 hours?
31 mg
A nurse is caring for a client who has just been prescribed a loading dose of a drug. The nurse
should explain what rationale to the client for administering a loading dose?
"We want to make sure you get the benefits of the drug as quickly as possible."
The nurse understands that the dosage recommended by drug manufacturers is based on an
individual weighing:
150 lb (68 kg).
A client will soon be discharged home from the hospital after a successful coronary artery
bypass graft (CABG). During client education about drug regimen, the nurse should prioritize
teaching about:
potential adverse effects of the drugs that the client will be taking.
We have an expert-written solution to this problem!
Drugs undergo biotransformation in the liver or gastrointestinal track. What benefit is produced
when the drugs become water soluable (hydrophilic)?
The drugs can be excreted through the kidneys.
Why is it important for the nurse to obtain baseline information from a client, such as a drug
profile, an accurate history of the client's usual abilities, and changes in abilities or health
status?
To determine any new signs and symptoms in the client that could be related to drug therapy
We have an expert-written solution to this problem!
A nurse is aware that older adults tend to have a significantly decreased rate of hepatic blood
flow compared with younger adults. What effect is this likely to have on pharmacokinetics and
pharmacodynamics in an older adult?
Drug clearance is likely to be slower.
,We have an expert-written solution to this problem!
Drugs injected intravenously (IV) reach their full strength in which timeframe?
Immediately
Drug excretion occurs mainly in which organ?
kidneys
A client, prescribed a drug that has an exceptionally narrow margin of safety, should be
educated about the need for what intervention?
serum drug level monitoring
Which factor accounts for the increased risk for drug reactions among clients aged 65 years and
older?
physiologic changes affecting all pharmacokinetic processes
We have an expert-written solution to this problem!
A 72-year-old man with pain issues is being given a drug by the intramuscular route. His serum
blood level concentrations have been erratic. The nurse suspects that this may be due to
decreased blood flow to tissues and muscles.
We have an expert-written solution to this problem!
A client has been diagnosed with cardiovascular disorder. The client is age 68; suffers from
intermittent joint pain and is under drug therapy; eats meat, salads, and fruits; prefers alternative
herb medications along with drug therapy; sometimes smokes; he lives alone and is looked after
by a caregiver. Which item of information has the greatest implication for planning his drug
therapy?
prefers alternative herb medications
The nurse is explaining the pharmacokinetics of a drug being administered to a client. What is
meant by the term "pharmakokinetics?"
actions of drugs
What is the most frequently used drug administration route in clinical practice?
oral
, With buccal medications, what factor affects absorption?
integrity of the mucous membranes
The nurse knows that a client is at high risk for developing drug tolerance because the client will
be taking which drug for a long period of time?
Hydromorphone (Dilaudid) for pain
When researching information about a drug, the nurse finds that the drug tightly binds to protein.
The nurse would interpret this to mean that the drug will:
have a long duration of action.
A client with complex health needs takes a large number of medications. In order to reduce the
likelihood of drug-food interactions, the nurse should encourage the client to:
avoid drinking grapefruit juice.
What drug administration route should be used to assure the best bioavailability as any
particular drug?
intravenous
We have an expert-written solution to this problem!
An experienced nurse has observed that female clients sometimes experience a drug's effects
for a longer time than male clients of similar age and size. The nurse should attribute this to
what factor?
Women have more fat cells so drugs depositing in fat will have a prolonged effect.
We have an expert-written solution to this problem!
A client is taking low-dose aspirin daily for her heart. The client is not receiving all the dosage of
the aspirin that is being ingested because of:
first-pass effect.
For what reason is the creatinine level alone not a good indicator of renal function in the older
adult?
There is a decline in overall muscle mass, which produces a lower creatinine level.
