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NSG530 / NSG 530 Exam 1 | Advanced
Pathophysiology | Questions & Verified Answers with
Rationales | 100% Correct | Grade A+
Interphase - (ANSWER)cell feeds, metabolizes and grows while replicating DNA in
preparation for mitosis
Prophase - (ANSWER)first appearance of chromosomes (will be 92)
Metaphase - (ANSWER)Centrioles pull chromosomes to opposite sides of cell
(chromatid) - 46 each side
Anaphase - (ANSWER)Centromeres split and sister chromatids are pulled apart
Telophase - (ANSWER)New nuclear membrane formed around each group of 46
chromosomes *When it goes right, euploid cells are produced*
Nondisjunction - (ANSWER)Error in meiosis in which homologous chromosomes
fail to separate.
Polyploidy - (ANSWER)condition in which an organism has extra sets of
chromosomes
Triploidy - (ANSWER)when an organism has three copies of every chromsome
instead of two
, 2
Tetrapoloidy - (ANSWER)euploid has 92 chromosomes and fetus usually does not
survive
Huntington's disease - (ANSWER)Single gene disorder (trinucleotide repeat
mutation)
Autosomal dominant (50% chance of passing it on)
Progressive neurologic disease with late onset (40s)
Prevention- genetic testing for pregnancy planning
Cystic fibrosis - (ANSWER)Single gene disorder (CFTR gene mutation)
Autosomal recessive
Most common in white children
Defective transport of chloride ions cause salt imbalance- thickened secretions,
digestive issues, malnutrition. Males and females
Must inherit two copies of gene (1 from each parent)
Turner syndrome - (ANSWER)XO chromosomal disorder, monosomy of X-affects
females
Short stature, webbed neck, undeveloped breasts but female genitalia, usually
sterile
Down syndrome - (ANSWER)Chromosomal disorder, trisomy 21
NSG530 / NSG 530 Exam 1 | Advanced
Pathophysiology | Questions & Verified Answers with
Rationales | 100% Correct | Grade A+
Interphase - (ANSWER)cell feeds, metabolizes and grows while replicating DNA in
preparation for mitosis
Prophase - (ANSWER)first appearance of chromosomes (will be 92)
Metaphase - (ANSWER)Centrioles pull chromosomes to opposite sides of cell
(chromatid) - 46 each side
Anaphase - (ANSWER)Centromeres split and sister chromatids are pulled apart
Telophase - (ANSWER)New nuclear membrane formed around each group of 46
chromosomes *When it goes right, euploid cells are produced*
Nondisjunction - (ANSWER)Error in meiosis in which homologous chromosomes
fail to separate.
Polyploidy - (ANSWER)condition in which an organism has extra sets of
chromosomes
Triploidy - (ANSWER)when an organism has three copies of every chromsome
instead of two
, 2
Tetrapoloidy - (ANSWER)euploid has 92 chromosomes and fetus usually does not
survive
Huntington's disease - (ANSWER)Single gene disorder (trinucleotide repeat
mutation)
Autosomal dominant (50% chance of passing it on)
Progressive neurologic disease with late onset (40s)
Prevention- genetic testing for pregnancy planning
Cystic fibrosis - (ANSWER)Single gene disorder (CFTR gene mutation)
Autosomal recessive
Most common in white children
Defective transport of chloride ions cause salt imbalance- thickened secretions,
digestive issues, malnutrition. Males and females
Must inherit two copies of gene (1 from each parent)
Turner syndrome - (ANSWER)XO chromosomal disorder, monosomy of X-affects
females
Short stature, webbed neck, undeveloped breasts but female genitalia, usually
sterile
Down syndrome - (ANSWER)Chromosomal disorder, trisomy 21
