Chapter 54 Biological Response–Modifying Drugs and Antirheumatic Drugs
Sealock Lilley’s Pharmacology for Canadian Health Care Practice
MULTIPLE CHOICE
1. A patient is receiving interferon therapy. What expected adverse effect should the nurse tell this
patient about?
a. Anemia
b. Increased appetite
c. Constipation
d. Flulike effects
ANS D
Patients who receive interferon therapy may experience flulike effects, fatigue, anorexia, dizziness,
nausea, vomiting, and diarrhea. Patients on interferon therapy will not experience anemia, increased
appetite, or constipation.
DIF Cognitive Level Comprehension
2. Lymphokine-activated killer (LAK) cells, which multiply as a result of interleukin therapy, do what?
a. They directly inhibit deoxyribonucleic acid (DNA) and protein synthesis.
b. They destroy cancer cells and ignore normal cells.
c. They destroy cancer cells by destroying all types of cells.
d. They prevent virus replication and prevent viruses from penetrating healthy cells.
ANS B
LAK cells recognize cancer cells, ignore normal cells, and destroy the cancer cells on contact, thus
avoiding the toxic effects of antineoplastic drugs.
, DIF Cognitive Level Knowledge
3. Capillary leak syndrome during interleukin therapy may result in which problem?
a. Renal failure
b. Asthma
c. Ecchymosis d.
Heart failure
ANS D
When capillary leak syndrome occurs, the capillaries lose their ability to retain vital colloids, and these
substances migrate into the surrounding tissues, resulting in massive fluid retention. As a result, heart
failure, myocardial infarction, and dysrhythmias may occur.
DIF Cognitive Level Comprehension
4. Which is an effect of colony-stimulating factors (CSFs)?
a. Multiplication of T cells
b. Decreased neutrophil counts
c. Increased cytotoxic activity of natural killer (NK)
cells d. Stimulation of certain immune cells
ANS D
CSFs prevent the decrease of neutrophil counts and stimulate certain immune cells (macrophages
and granulocytes) to destroy or inhibit the growth of tumour cells and virus- or fungus-infected
cells.
DIF Cognitive Level Knowledge
5. Which is true in regard to therapy with interferon drugs?
Sealock Lilley’s Pharmacology for Canadian Health Care Practice
MULTIPLE CHOICE
1. A patient is receiving interferon therapy. What expected adverse effect should the nurse tell this
patient about?
a. Anemia
b. Increased appetite
c. Constipation
d. Flulike effects
ANS D
Patients who receive interferon therapy may experience flulike effects, fatigue, anorexia, dizziness,
nausea, vomiting, and diarrhea. Patients on interferon therapy will not experience anemia, increased
appetite, or constipation.
DIF Cognitive Level Comprehension
2. Lymphokine-activated killer (LAK) cells, which multiply as a result of interleukin therapy, do what?
a. They directly inhibit deoxyribonucleic acid (DNA) and protein synthesis.
b. They destroy cancer cells and ignore normal cells.
c. They destroy cancer cells by destroying all types of cells.
d. They prevent virus replication and prevent viruses from penetrating healthy cells.
ANS B
LAK cells recognize cancer cells, ignore normal cells, and destroy the cancer cells on contact, thus
avoiding the toxic effects of antineoplastic drugs.
, DIF Cognitive Level Knowledge
3. Capillary leak syndrome during interleukin therapy may result in which problem?
a. Renal failure
b. Asthma
c. Ecchymosis d.
Heart failure
ANS D
When capillary leak syndrome occurs, the capillaries lose their ability to retain vital colloids, and these
substances migrate into the surrounding tissues, resulting in massive fluid retention. As a result, heart
failure, myocardial infarction, and dysrhythmias may occur.
DIF Cognitive Level Comprehension
4. Which is an effect of colony-stimulating factors (CSFs)?
a. Multiplication of T cells
b. Decreased neutrophil counts
c. Increased cytotoxic activity of natural killer (NK)
cells d. Stimulation of certain immune cells
ANS D
CSFs prevent the decrease of neutrophil counts and stimulate certain immune cells (macrophages
and granulocytes) to destroy or inhibit the growth of tumour cells and virus- or fungus-infected
cells.
DIF Cognitive Level Knowledge
5. Which is true in regard to therapy with interferon drugs?
