Chapter 47 Antifungal Drugs
Sealock Lilley’s Pharmacology for Canadian Health Care Practice
MULTIPLE CHOICE
1. A patient has been prescribed fluconazole. What should the nurse tell the patient to do in regard to
this medication?
a. Have liver function tested.
b. Take antacids with the drug to minimize gastrointestinal upset.
c. Take the drug with a large glass of orange juice or water.
d. Take the drug 2 hours before a meal or 2 hours after a meal.
ANS A
Patients receiving fluconazole requires close assessment of pre-existing GI problems and kidney and
liver functioning due to drug-induced adverse effects impacting these systems.
DIF Cognitive Level Comprehension
2. Which is a contraindication to the use of griseofulvin?
a. Porphyria
b. Renal disease
c. Cardiac disease
d. Meningitis
ANS A
Griseofulvin is contraindicated in patients with porphyria.
DIF Cognitive Level Knowledge
3. The nurse is administering an antifungal medication. What assessment finding may indicate
medication-induced renal damage?
a. Rash and chills
b. Increased urinary output
c. Decreased levels of blood urea nitrogen (BUN) and creatinine
d. A weight gain of 2.5 kg in 1 week
ANS D
, A weight gain of more than 1 kg in in a 24-hour period or 2.3 kg or more in 1 week may indicate possible
medication-induced kidney damage and the need for prompt medical attention. BUN and creatinine
levels will increase, not decrease, if renal damage occurs. Urine output would decrease if renal damage
were indicated. Rash and chills are not symptoms of renal damage.
DIF Cognitive Level Comprehension
4. Which antifungal drug causes increased effects of oral anticoagulants?
a. miconazole
b. fluconazole
c. ketoconazole
d. amphotericin B (Fungizone®)
ANS B
Fluconazole causes increased effects of oral anticoagulants.
DIF Cognitive Level Knowledge
5. During administration of amphotericin B (Fungizone), the patient may experience severe adverse
effects, such as fever, chills, hypotension, tachycardia, malaise, nausea, and headache. The correct
action for the nurse to take is to
a. discontinue the infusion immediately.
b. reduce the infusion rate gradually until the adverse effects subside.
c. administer the medication by rapid intravenous (IV) infusion to reduce the potential adverse
effects.
d. anticipating these effects, pretreat the patient with an antipyretic, such as acetaminophen, an
antihistamine, and an antiemetic drug.
ANS D
Pretreatment with an antipyretic (acetaminophen), an antihistamine, and an antiemetic drug is the
appropriate action to reduce the adverse effects of amphotericin B therapy.
DIF Cognitive Level Analysis
Sealock Lilley’s Pharmacology for Canadian Health Care Practice
MULTIPLE CHOICE
1. A patient has been prescribed fluconazole. What should the nurse tell the patient to do in regard to
this medication?
a. Have liver function tested.
b. Take antacids with the drug to minimize gastrointestinal upset.
c. Take the drug with a large glass of orange juice or water.
d. Take the drug 2 hours before a meal or 2 hours after a meal.
ANS A
Patients receiving fluconazole requires close assessment of pre-existing GI problems and kidney and
liver functioning due to drug-induced adverse effects impacting these systems.
DIF Cognitive Level Comprehension
2. Which is a contraindication to the use of griseofulvin?
a. Porphyria
b. Renal disease
c. Cardiac disease
d. Meningitis
ANS A
Griseofulvin is contraindicated in patients with porphyria.
DIF Cognitive Level Knowledge
3. The nurse is administering an antifungal medication. What assessment finding may indicate
medication-induced renal damage?
a. Rash and chills
b. Increased urinary output
c. Decreased levels of blood urea nitrogen (BUN) and creatinine
d. A weight gain of 2.5 kg in 1 week
ANS D
, A weight gain of more than 1 kg in in a 24-hour period or 2.3 kg or more in 1 week may indicate possible
medication-induced kidney damage and the need for prompt medical attention. BUN and creatinine
levels will increase, not decrease, if renal damage occurs. Urine output would decrease if renal damage
were indicated. Rash and chills are not symptoms of renal damage.
DIF Cognitive Level Comprehension
4. Which antifungal drug causes increased effects of oral anticoagulants?
a. miconazole
b. fluconazole
c. ketoconazole
d. amphotericin B (Fungizone®)
ANS B
Fluconazole causes increased effects of oral anticoagulants.
DIF Cognitive Level Knowledge
5. During administration of amphotericin B (Fungizone), the patient may experience severe adverse
effects, such as fever, chills, hypotension, tachycardia, malaise, nausea, and headache. The correct
action for the nurse to take is to
a. discontinue the infusion immediately.
b. reduce the infusion rate gradually until the adverse effects subside.
c. administer the medication by rapid intravenous (IV) infusion to reduce the potential adverse
effects.
d. anticipating these effects, pretreat the patient with an antipyretic, such as acetaminophen, an
antihistamine, and an antiemetic drug.
ANS D
Pretreatment with an antipyretic (acetaminophen), an antihistamine, and an antiemetic drug is the
appropriate action to reduce the adverse effects of amphotericin B therapy.
DIF Cognitive Level Analysis
