UNE MEDICAL BIOCHEMISTRY 1005 UNIT 3 EXAM | QUESTIONS AND
ANSWERS | VERIFIED AND WELL DETAILED ANSWERS | LATEST
EXAM VERSION
What are the direct products of B-Oxidation - CORRECT ANSWER - 1) NADH,
FADH2 used in ETC --> ATP
2) Acetyl-CoA
a) Substrate for ketogenesis
b) Allosterically activates pyruvate carboxylase --> gluconeogenesis
3) ATP used in anabolic process in fasted state
a) Gluconeogenesis
b) Urea Cycle
An 11-year-old girl is brought to the emergency department by her father. He
reports she has recently been very thirsty and needing to make frequent trips to the
bathroom. At her soccer game today, she complained of lightheadedness and that
the symptoms did not resolve even after drinking a power beverage. A rapid
dipstick test revealed glucose in her urine and further diagnostics are consistent
with a diagnosis of type 1 diabetes. Evaluation of this girl's liver would reveal an
increased rate of which of the following processes?
a) Fatty Acid Synthesis
b) Glycogenesis
c) Glycolysis
d) Ketogenesis
e) Protein Synthesis - CORRECT ANSWER - d) Ketogenesis
,i) Type 1 Diabetes: loss of insulin production Increased Glucagon
ii) Fed state
(1) Fatty acid synthesis, glycogenesis, glycolysis
iii) Fasted state
(1) B-oxidation - increase Acetyl-CoA for ketone synthesis & Lipolyis increases
free fatty acids for oxidation increase Acetyl-CoA
What is the role of Adipose Tissue in metabolism? - CORRECT ANSWER -
Stores Triacylglycerols (TAGs) --> broken down into fatty acids during fasted state
to use as energy
A 5-year-old female is brought to the emergency department by her mother. She is
a type I diabetic and has not taken her insulin while away at a day camp. The child
is unresponsive. Which of the following enzymes is phosphorylated and active
under these conditions?
a) Acetyl-CoA Carboxylase
b) Hormone-sensitive Lipase
c) Glycogen Synthase
d) Phosphofructokinase 2
a) Pyruvate Kinase - CORRECT ANSWER - b) Hormone-sensitive Lipase
Fed state
(1) Acetyl-CoA Carboxylase - fatty acid synthesis
(2) Glycogen synthase - inactivated by phosphorylation; active in fed state
, (3) PFK2 - inactivated by phosphorylation
(4) Pyruvate Kinase - inactivated by phosphorylation
1) The process of ketogenesis refers to the conversion of acetyl-CoA to which of
the following compounds?
a) Methylmalonyl-CoA
b) Malonyl-CoA
c) B-Hydroxybutyrate
d) Propionyl-CoA - CORRECT ANSWER - c) B-Hydroxybutyrate
What is the compound formed from the spontaneous decarboxylation of
acetoacetate in the blood that is responsible for a fruity odor on the breath of
someone with ketonemia?
a) B-Hydroxybutyrate
b) Acetyl-CoA
c) Acetone
d) Succinyl-CoA - CORRECT ANSWER - c) Acetone
1) A precipitating factor for the ketonemia associated with ketogenic diets,
starvation, and untreated type 1 diabetes is:
a) High-fat diet
b) Defects in enzymes of B-oxidation
ANSWERS | VERIFIED AND WELL DETAILED ANSWERS | LATEST
EXAM VERSION
What are the direct products of B-Oxidation - CORRECT ANSWER - 1) NADH,
FADH2 used in ETC --> ATP
2) Acetyl-CoA
a) Substrate for ketogenesis
b) Allosterically activates pyruvate carboxylase --> gluconeogenesis
3) ATP used in anabolic process in fasted state
a) Gluconeogenesis
b) Urea Cycle
An 11-year-old girl is brought to the emergency department by her father. He
reports she has recently been very thirsty and needing to make frequent trips to the
bathroom. At her soccer game today, she complained of lightheadedness and that
the symptoms did not resolve even after drinking a power beverage. A rapid
dipstick test revealed glucose in her urine and further diagnostics are consistent
with a diagnosis of type 1 diabetes. Evaluation of this girl's liver would reveal an
increased rate of which of the following processes?
a) Fatty Acid Synthesis
b) Glycogenesis
c) Glycolysis
d) Ketogenesis
e) Protein Synthesis - CORRECT ANSWER - d) Ketogenesis
,i) Type 1 Diabetes: loss of insulin production Increased Glucagon
ii) Fed state
(1) Fatty acid synthesis, glycogenesis, glycolysis
iii) Fasted state
(1) B-oxidation - increase Acetyl-CoA for ketone synthesis & Lipolyis increases
free fatty acids for oxidation increase Acetyl-CoA
What is the role of Adipose Tissue in metabolism? - CORRECT ANSWER -
Stores Triacylglycerols (TAGs) --> broken down into fatty acids during fasted state
to use as energy
A 5-year-old female is brought to the emergency department by her mother. She is
a type I diabetic and has not taken her insulin while away at a day camp. The child
is unresponsive. Which of the following enzymes is phosphorylated and active
under these conditions?
a) Acetyl-CoA Carboxylase
b) Hormone-sensitive Lipase
c) Glycogen Synthase
d) Phosphofructokinase 2
a) Pyruvate Kinase - CORRECT ANSWER - b) Hormone-sensitive Lipase
Fed state
(1) Acetyl-CoA Carboxylase - fatty acid synthesis
(2) Glycogen synthase - inactivated by phosphorylation; active in fed state
, (3) PFK2 - inactivated by phosphorylation
(4) Pyruvate Kinase - inactivated by phosphorylation
1) The process of ketogenesis refers to the conversion of acetyl-CoA to which of
the following compounds?
a) Methylmalonyl-CoA
b) Malonyl-CoA
c) B-Hydroxybutyrate
d) Propionyl-CoA - CORRECT ANSWER - c) B-Hydroxybutyrate
What is the compound formed from the spontaneous decarboxylation of
acetoacetate in the blood that is responsible for a fruity odor on the breath of
someone with ketonemia?
a) B-Hydroxybutyrate
b) Acetyl-CoA
c) Acetone
d) Succinyl-CoA - CORRECT ANSWER - c) Acetone
1) A precipitating factor for the ketonemia associated with ketogenic diets,
starvation, and untreated type 1 diabetes is:
a) High-fat diet
b) Defects in enzymes of B-oxidation
