WALDEN NURS 6630 PSYCHOPHARMACOLOGY
LATEST MIDTERM STUDY GUIDE WITH 170+
QUESTIONS & VERIFIED ANSWERS (BEST FOR
PRACTICE) | NURS 6630 PSYCHOPHARMACOLOGY
MIDTERM STUDY GUIDE 2025/2026
1. This class of antidepressants binds to presynaptic SERT and inhibits them
from reuptake of serotonin to increase levels in the synaptic cleft to bind
with postsynaptic 5HT2 receptors - ANSWER-SSRIs
2. First line therapy for MDD due to milder side effect profiles - ANSWER-
SSRIs
3. Six Common SSRIs - ANSWER-citalopram, citalopram, fluoxetine,
fluvoxamine, sertraline, paroxetine
4. Onset of therapeutic benefit from SSRIs - ANSWER-4-6 weeks
5. In addition to MDD, SSRIs also treat - ANSWER-Chronic Anxiety, PTSD,
OCD,
and eating disorders (bulimia)
6. Five Common side effects of SSRIs include - ANSWER-Anxiety,
insomnia, GI distress, sexual dysfunction (ED), SIADH
7. Severe side effect of SSRIs in children/adolescents under age 25 years
old - ANSWER-suicidal ideation
8. Life threatening adverse effect of SSRIs, especially when used in
combination with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) -
ANSWER-Serotonin Syndrome
9. Excess accumulation of serotonin resulting in overstimulation of the
nervous system - ANSWER-Serotonin Syndrome
10.Seven symptoms of Serotonin Syndrome - ANSWER-Flushing,
hyperthermia, agitation, muscle rigidity, seizure, coma, Hyperreflexia
11.The treatment for serotonin syndrome - ANSWER-Cyproheptadine
(5-HT2 receptor antagonist)
,12.Cyproheptadine treats serotonin syndrome by - ANSWER-blocking
5-HT2 receptors (serotonin antagonist)
13.Serotonin regulates - ANSWER-Mood, emotion, feeding, and
reproductive behavior
14.When SSRIs or SNRIs are stopped abruptly, common symptoms of
withdrawal include - ANSWER-Irritability, headaches, and insomnia
15.Medicine specific side effect of citalopram - ANSWER-Prolonged QT
interval (normal=0.4.-0.44 seconds)
16.This SSRI is pregnancy category D due to associations with congenital
heart defects - ANSWER-Paroxetine
17.All SSRIs but paroxetine (D) are pregnancy category - ANSWER-C
18.Three SSRIs that are inhibitors of Cytochrome P450 enzymes -
ANSWER- fluoxetine, fluvoxamine, and paroxetine
19.Five common SNRIs include - ANSWER-duloxetine, venlafaxine,
desvenlafaxine, milnacipran, levomilnacipran
20.This antidepressant class of medications works by binding to presynaptic
SERT and NET to inhibit them from reuptake of serotonin and
norepinephrine to increase their levels in the synaptic cleft - ANSWER-
SNRIs
21.In addition to MDD SNRIs treat - ANSWER-Anxiety and
neuropathic pain (peripheral neuropathy)
22.Medication specific indications of duloxetine: - ANSWER-urinary
incontinence and Fibromyalgia
23.Medication specific indications of venlafaxine: - ANSWER-social
anxiety, panic disorders, PTSD, OCD, postmenopausal hot flashes
24.Six common side effects of SNRIs include: - ANSWER-Insomnia, nausea,
sexual dysfunction, hypertension, sweating, headaches
, 25.Severe side effect of SNRIs in children/adolescents under age 25 years
old: - ANSWER-suicidal ideation
26.Life threatening adverse effect of SNRIs, especially when used in
combination with other serotonergic drugs: - ANSWER-Serotonin
Syndrome
27.This SNRI is an inhibitor of Cytochrome P450 enzymes: - ANSWER-
venlafaxine
28.This SNRI is hepatotoxic: - ANSWER-duloxetine
LATEST MIDTERM STUDY GUIDE WITH 170+
QUESTIONS & VERIFIED ANSWERS (BEST FOR
PRACTICE) | NURS 6630 PSYCHOPHARMACOLOGY
MIDTERM STUDY GUIDE 2025/2026
1. This class of antidepressants binds to presynaptic SERT and inhibits them
from reuptake of serotonin to increase levels in the synaptic cleft to bind
with postsynaptic 5HT2 receptors - ANSWER-SSRIs
2. First line therapy for MDD due to milder side effect profiles - ANSWER-
SSRIs
3. Six Common SSRIs - ANSWER-citalopram, citalopram, fluoxetine,
fluvoxamine, sertraline, paroxetine
4. Onset of therapeutic benefit from SSRIs - ANSWER-4-6 weeks
5. In addition to MDD, SSRIs also treat - ANSWER-Chronic Anxiety, PTSD,
OCD,
and eating disorders (bulimia)
6. Five Common side effects of SSRIs include - ANSWER-Anxiety,
insomnia, GI distress, sexual dysfunction (ED), SIADH
7. Severe side effect of SSRIs in children/adolescents under age 25 years
old - ANSWER-suicidal ideation
8. Life threatening adverse effect of SSRIs, especially when used in
combination with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) -
ANSWER-Serotonin Syndrome
9. Excess accumulation of serotonin resulting in overstimulation of the
nervous system - ANSWER-Serotonin Syndrome
10.Seven symptoms of Serotonin Syndrome - ANSWER-Flushing,
hyperthermia, agitation, muscle rigidity, seizure, coma, Hyperreflexia
11.The treatment for serotonin syndrome - ANSWER-Cyproheptadine
(5-HT2 receptor antagonist)
,12.Cyproheptadine treats serotonin syndrome by - ANSWER-blocking
5-HT2 receptors (serotonin antagonist)
13.Serotonin regulates - ANSWER-Mood, emotion, feeding, and
reproductive behavior
14.When SSRIs or SNRIs are stopped abruptly, common symptoms of
withdrawal include - ANSWER-Irritability, headaches, and insomnia
15.Medicine specific side effect of citalopram - ANSWER-Prolonged QT
interval (normal=0.4.-0.44 seconds)
16.This SSRI is pregnancy category D due to associations with congenital
heart defects - ANSWER-Paroxetine
17.All SSRIs but paroxetine (D) are pregnancy category - ANSWER-C
18.Three SSRIs that are inhibitors of Cytochrome P450 enzymes -
ANSWER- fluoxetine, fluvoxamine, and paroxetine
19.Five common SNRIs include - ANSWER-duloxetine, venlafaxine,
desvenlafaxine, milnacipran, levomilnacipran
20.This antidepressant class of medications works by binding to presynaptic
SERT and NET to inhibit them from reuptake of serotonin and
norepinephrine to increase their levels in the synaptic cleft - ANSWER-
SNRIs
21.In addition to MDD SNRIs treat - ANSWER-Anxiety and
neuropathic pain (peripheral neuropathy)
22.Medication specific indications of duloxetine: - ANSWER-urinary
incontinence and Fibromyalgia
23.Medication specific indications of venlafaxine: - ANSWER-social
anxiety, panic disorders, PTSD, OCD, postmenopausal hot flashes
24.Six common side effects of SNRIs include: - ANSWER-Insomnia, nausea,
sexual dysfunction, hypertension, sweating, headaches
, 25.Severe side effect of SNRIs in children/adolescents under age 25 years
old: - ANSWER-suicidal ideation
26.Life threatening adverse effect of SNRIs, especially when used in
combination with other serotonergic drugs: - ANSWER-Serotonin
Syndrome
27.This SNRI is an inhibitor of Cytochrome P450 enzymes: - ANSWER-
venlafaxine
28.This SNRI is hepatotoxic: - ANSWER-duloxetine
