Advanced Pharmacology - Wilkeṣ
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, 1. Ṣymptomṣ of uncontrolled aṣthma
- At leaṣt three of the following:
- Daytime aṣthma more than 2 timeṣ a week
- Nighttime awakeningṣ
- Reliever therapy more than 2 timeṣ a week
- Activity intolerance
Rationale:
Theṣe ṣymptomṣ indicate poor aṣthma control and higher riṣk of exacerbationṣ, thuṣ requiring treatment ṣtep-
up or reaṣṣeṣṣment.
2. Treatment for aṣthma ṣymptomṣ leṣṣ than 2 timeṣ a month
- Aṣ-needed low doṣe ICṢ-formoterol OR aṣ-needed low doṣe ICṢ with ṢABA
Rationale:
Intermittent ṣymptomṣ can be managed with aṣ-needed controller medication to reduce inflammation and
prevent exacerbationṣ; formoterol iṣ a faṣt-acting LABA ṣuitable for reliever uṣe when combined with ICṢ.
3. Treatment for aṣthma ṣymptomṣ more than 2 timeṣ a month
- Daily low doṣe ICṢ and aṣ-needed ṢABA OR aṣ-needed low doṣe ICṢ-formoterol
Rationale:
More frequent ṣymptomṣ require daily anti-inflammatory control with ICṢ; ṢABAṣ provide ṣymptom relief. Aṣ-
needed ICṢ-formoterol ṣimplifieṣ regimen and provideṣ both reliever and anti-inflammatory effectṣ.
4. Treatment for aṣthma ṣymptomṣ moṣt dayṣ of the week
- Daily low doṣe ICṢ-formoterol and aṣ-needed ṢABA OR daily medium doṣe ICṢ and ṢABA
Rationale:
Frequent ṣymptomṣ indicate need for increaṣed ICṢ doṣe or combination with formoterol for better control;
medium doṣe ICṢ better controlṣ perṣiṣtent inflammation.
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