Test Bank For Cellular and Molecular Immunology, 11th Edition by Abul K. Abbas| Verified Chapters 1-21|| Latest Edition 2025

,Table of Contents
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Chapter 01 Properties and Overview of Immune Responses
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Chapter 02 Cells and Tissues of the Immune System
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Chapter 03 Leukocyte Circulation and Migration Into Tissues
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Chapter 04 Innate Immunity
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Chapter 05 Antibodies and Antigens
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Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
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Histocompatibility Complex Molecules
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Chapter 07 Immune Receptors and Signal Transduction
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Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
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Chapter 09 Activation of T Lymphocytes
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Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
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Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
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Chapter 12 B Cell Activation and Antibody Production
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Chapter 13 Effector Mechanisms of Humoral Immunity
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Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
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Chapter 15 Immunologic Tolerance and Autoimmunity
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Chapter 16 Immunity to Microbes
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Chapter 17 Transplantation Immunology
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Chapter 18 Tumor Immunology
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Chapter 19 Hypersensitivity Disorders
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Chapter 20 Allergy
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Chapter 21 Primary and Acquired Immunodeficiencies
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,Chapter 01: Properties and Overview of Immune Responses
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Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 11th Edition
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MULTIPLE CHOICE nf




1. The principal function of the immune system is:
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a. Defense against cancer nf nf


b. Repair of injured tissues nf nf nf


c. Defense against microbial infections nf nf nf


d. Prevention of inflammatory diseases nf nf nf


e. Protection against environmental toxins nf nf nf




ANS: C n f


The immune system has evolved in the setting of selective pressures imposed by microbial
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infections. Although immune responses to cancer may occur, the concept that ―immunosur
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veillance‖ against cancer is a principal function of the immune system is controversial. Re
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pair of injured tissues may be a secondary consequence of the immune responses and infla
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mmation. Although the immune system has regulatory features that are needed to prevent
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excessive inflammation, prevention of inflammatory diseases is not a primary function. Th
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e immune system can protect against microbial toxins, but it generally does not offer protec
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tion against toxins of nonbiologic origin.
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2. Which of the following infectious diseases was prevented by the first successful
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vaccination?
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a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C n f


In 1798, Edward Jenner reported the first intentional successful vaccination, which was ag
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ainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, s
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mallpox was reported to be eradicated worldwide by a vaccination program. Effective vac
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cines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th centur
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y and are widely used. There is no effective vaccine against Mycobacterium tuberculosis.
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3. Which of the following is a unique property of the adaptive immune system?
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a. Highly diverse repertoire of specificities for antigens
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b. Self-nonself discrimination nf


c. Recognition of microbial structures by both cell-associated and soluble receptors
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d. Protection against viral infections nf nf nf


e. Responses that have the same kinetics and magnitude on repeated exposure to the
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same microbe
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ANS: n f A

, Highly diverse repertoires of specificities for antigens are found only in T and B lymphoc
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ytes, which are the central cellular components of the adaptive immune system. Both the i
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nnate and the adaptive immune systems use cell-
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associated and soluble receptors to recognize microbes, display some degree of self-
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nonself discrimination, and protect against viruses. On repeated exposure to the same micr
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obe, the adaptive immune response becomes more rapid and of greater magnitude; this is t
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he manifestation of memory.
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4. Antibodies and T lymphocytes are the respective mediators of which two types of
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immunity?
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a. Innate and adaptive nf nf


b. Passive and active nf nf


c. Specific and nonspecific nf nf


d. Humoral and cell-mediated nf nf


e. Adult and neonatal nf nf




ANS: D n f


Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes
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produce antibodies, which are the recognition and effector molecules of humoral immune r
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esponses to extracellular pathogens. T cells recognize and promote eradication of intracellul
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ar pathogens in cell-
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mediated immunity. Passive and active immunity both can be mediated by either B or T lym
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phocytes. Specific immunity is another term for adaptive immunity. Both B and T lymphocy
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tes participate in adult adaptive immunity but are still developing in the neonatal period.
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5. The two major functional classes of effector T lymphocytes are:
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a. Helper T lymphocytes and cytotoxic T lymphocytes nf nf nf nf nf nf


b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
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cyStes nf nf nf nf


c. Memory T cells and effector T cells nf nf nf nf nf nf


d. Helper cells and antigen-presenting cells nf nf nf nf


e. Cytotoxic T lymphocytes and target cells nf nf nf nf nf




ANS: A n f


T cells can be classified into effector subsets that perform different effector functions. Most
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effector T cells are either helper T lymphocytes, which enhance the responses of other im
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mune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes, w
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hich directly kill infected cells. Natural killer cells are not T lymphocytes.
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Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. nf nf nf nf nf nf nf nf nf nf nf nf nf nf




6. Which of the following cell types is required for all adaptive humoral immune responses?
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a. Natural killer cells nf nf


b. Dendritic cells nf


c. Cytolytic T lymphocytes nf nf


d. B lymphocytes nf


e. Helper T lymphocytes nf nf




ANS: D n f


Humoral immune responses are antibody- nf nf nf nf


mediated immune responses, and all antibodies are made by B lymphocytes and no other
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cell type.
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