TEST BANK
Tietz Fundamentals of Clinical Chemistry and Molecular
Diagnostics
Nader Rifai
8th Edition
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Nader Rifai TEST BANK
Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
Table of contents:
I. Principles OfeLaboratory Medicine
Chapter 1. Clinical Chemistry, MoleculareDiagnostics, and Laboratory Medicine
Chaptere2. Selection and Analytical Evaluation of Methods ² With Statistical Techniques
Chaptere3. Clinical Evaluation of Methods
Chapter 4. Evidence-Based Laboratory Medicine
Chaptere5. Establishmenteand Use of Reference Values
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
Chapter 7. Quality Management
II. Analytical Techniques And Instrumentation
Chapter 8. Principles of BasiceTechniqueseand Laboratory Safety
Chapter 9. Optical Techniques
Chaptere10. Electrochemistry and Chemical Sensors
Chaptere11. Electrophoresis
Chapter 12. Chromatography
Chaptere13. Mass Spectrometry
Chaptere14. Enzyme and Rate Analyses
Chapter 15. Immunochemical Techniques
Chaptere16 Automation
Chaptere17. Point-of-Care Instrumentation
III. Analytes
Chaptere18. Amino Acids, Peptides, and Proteins
Chaptere19. Serum Enzymes
Chapter 20. Tumor Markers and Cancer Genes
Chapter 21. Kidney Function Tests ² Creatinine, GFR, Urea, and Uric Acid
Chaptere22. Carbohydrates
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
Chaptere24. Electrolytes and Blood Gases
Chaptere25. Hormones
Chapter 26. Catecholamines and Serotonin
Chaptere27. Vitamins, Trace Elements, Nutritional Assessment
Chaptere28. Hemoglobin, Iron, and Bilirubin
Chapter 29. Porphyrins and Porphyrias
Chapter 30. Therapeutic Drugs and Their Management
Chaptere31. Clinical Toxicology
Chapter 32. ToxiceMetals
IV. Pathophysiology
Chaptere33. Diabetes
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Nader Rifai TEST BANK
Chapter 34. Cardiovascular Disease
Chapter 35. Kidney Disease
Chaptere36. Physiology andeDisorders of Water, Electrolyte, and Acid-Base Metabolism
Chaptere37. LivereDisease
Chapter 38. Gastrointestinal and Pancreatic Diseases
Chaptere39. Disorders of Bone and Mineral Metabolism
Chapter 40. Disorders of the Pituitary Gland
Chapter 41. Disorders of the Adrenal Cortex
Chaptere42. Thyroid Disorders
Chaptere43. Reproduction-Related Disorders
Chapter 44. Pregnancyand Prenatal Testing
Chaptere45. Newborn Screening and Inborn Errors of Metabolism
Chaptere46. Pharmacogenetics
V. MoleculareDiagnostics
Chaptere47. Principles of MoleculareBiology
Chaptere48. Nucleic Acid Techniques and Applications
Chapter 49. Genomes and Nucleic Acid Alterations
, Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Nader Rifai TEST BANK
Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
Test Bank
MULTIPLE CHOICE
1. An individual working in a clinical chemistry laboratory is married to a sales representative
who works for a company that sells chemistry laboratory supplies. When the laboratory
manager requests a list of needed supplies, cost of supplies, and vendors, this individual only
UHFRPPHQGVWKHVSRXVH¶VFRPSDQ\DVWKHYHQGRU7KLVLVFRQVLGHUHGWREHD Q
a. accounting issue.
b. possible conflict of interest.
c. maintenance of confidentiality issue.
d. problem with resource allocation.
ANS: B
Concern has been raised over the interrelationships between practitioners in the medical field
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
Similarly, relationships have been scrutinized between clinical laboratorians and
manufacturers and providers of diagnostic equipment and supplies. These concerns led the
National Institutes of Health (NIH) in 1995 to require official institutional review of financial
disclosure by researchers and management of situations in which disclosure indicates potential
conflicts of interest.
DIF: 1 REF: Page 4-5 OBJ: 6 | 7
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce the
pain following her recent surgery. A friend of the patient claims that the same painkiller
³ZRUNHGZRQGHUV´WRUHGXFHKHUSDLQDIWHUWKHVDPH surgery. The physician states that the
difference in the effect of the drug might be caused by ____, which is studied in
pharmacogenetics.
a. epidemiology
b. an inherited disease
c. a conflict of interest
d. a genetic variation in drug-metabolizing enzymes
ANS: D
Pharmacogenetics is the study of the genetic variation of drug metabolism between
individuals.
DIF: 1 REF: Page 3 OBJ: 1
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
name of a close friend printed on the bar-coded label. The genetic test that is ordered on the
IULHQG¶VVDPSOHZRXOGSURYLGHGLDJQRVWLFLQIRUPDWLRQDERXWDGLVRUGHUWKDWKDVDSRRU
prognosis, and the test is usually performed by John. He asks a fellow employee to analyze
the sample for him and not divulge the results. This ethical issue concerns:
a. confidentiality of patient genetic and medical information.
b. a conflict of interest.
c. resource allocation.
Tietz Fundamentals of Clinical Chemistry and Molecular
Diagnostics
Nader Rifai
8th Edition
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Nader Rifai TEST BANK
Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
Table of contents:
I. Principles OfeLaboratory Medicine
Chapter 1. Clinical Chemistry, MoleculareDiagnostics, and Laboratory Medicine
Chaptere2. Selection and Analytical Evaluation of Methods ² With Statistical Techniques
Chaptere3. Clinical Evaluation of Methods
Chapter 4. Evidence-Based Laboratory Medicine
Chaptere5. Establishmenteand Use of Reference Values
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
Chapter 7. Quality Management
II. Analytical Techniques And Instrumentation
Chapter 8. Principles of BasiceTechniqueseand Laboratory Safety
Chapter 9. Optical Techniques
Chaptere10. Electrochemistry and Chemical Sensors
Chaptere11. Electrophoresis
Chapter 12. Chromatography
Chaptere13. Mass Spectrometry
Chaptere14. Enzyme and Rate Analyses
Chapter 15. Immunochemical Techniques
Chaptere16 Automation
Chaptere17. Point-of-Care Instrumentation
III. Analytes
Chaptere18. Amino Acids, Peptides, and Proteins
Chaptere19. Serum Enzymes
Chapter 20. Tumor Markers and Cancer Genes
Chapter 21. Kidney Function Tests ² Creatinine, GFR, Urea, and Uric Acid
Chaptere22. Carbohydrates
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
Chaptere24. Electrolytes and Blood Gases
Chaptere25. Hormones
Chapter 26. Catecholamines and Serotonin
Chaptere27. Vitamins, Trace Elements, Nutritional Assessment
Chaptere28. Hemoglobin, Iron, and Bilirubin
Chapter 29. Porphyrins and Porphyrias
Chapter 30. Therapeutic Drugs and Their Management
Chaptere31. Clinical Toxicology
Chapter 32. ToxiceMetals
IV. Pathophysiology
Chaptere33. Diabetes
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Nader Rifai TEST BANK
Chapter 34. Cardiovascular Disease
Chapter 35. Kidney Disease
Chaptere36. Physiology andeDisorders of Water, Electrolyte, and Acid-Base Metabolism
Chaptere37. LivereDisease
Chapter 38. Gastrointestinal and Pancreatic Diseases
Chaptere39. Disorders of Bone and Mineral Metabolism
Chapter 40. Disorders of the Pituitary Gland
Chapter 41. Disorders of the Adrenal Cortex
Chaptere42. Thyroid Disorders
Chaptere43. Reproduction-Related Disorders
Chapter 44. Pregnancyand Prenatal Testing
Chaptere45. Newborn Screening and Inborn Errors of Metabolism
Chaptere46. Pharmacogenetics
V. MoleculareDiagnostics
Chaptere47. Principles of MoleculareBiology
Chaptere48. Nucleic Acid Techniques and Applications
Chapter 49. Genomes and Nucleic Acid Alterations
, Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Nader Rifai TEST BANK
Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
Test Bank
MULTIPLE CHOICE
1. An individual working in a clinical chemistry laboratory is married to a sales representative
who works for a company that sells chemistry laboratory supplies. When the laboratory
manager requests a list of needed supplies, cost of supplies, and vendors, this individual only
UHFRPPHQGVWKHVSRXVH¶VFRPSDQ\DVWKHYHQGRU7KLVLVFRQVLGHUHGWREHD Q
a. accounting issue.
b. possible conflict of interest.
c. maintenance of confidentiality issue.
d. problem with resource allocation.
ANS: B
Concern has been raised over the interrelationships between practitioners in the medical field
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
Similarly, relationships have been scrutinized between clinical laboratorians and
manufacturers and providers of diagnostic equipment and supplies. These concerns led the
National Institutes of Health (NIH) in 1995 to require official institutional review of financial
disclosure by researchers and management of situations in which disclosure indicates potential
conflicts of interest.
DIF: 1 REF: Page 4-5 OBJ: 6 | 7
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce the
pain following her recent surgery. A friend of the patient claims that the same painkiller
³ZRUNHGZRQGHUV´WRUHGXFHKHUSDLQDIWHUWKHVDPH surgery. The physician states that the
difference in the effect of the drug might be caused by ____, which is studied in
pharmacogenetics.
a. epidemiology
b. an inherited disease
c. a conflict of interest
d. a genetic variation in drug-metabolizing enzymes
ANS: D
Pharmacogenetics is the study of the genetic variation of drug metabolism between
individuals.
DIF: 1 REF: Page 3 OBJ: 1
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
name of a close friend printed on the bar-coded label. The genetic test that is ordered on the
IULHQG¶VVDPSOHZRXOGSURYLGHGLDJQRVWLFLQIRUPDWLRQDERXWDGLVRUGHUWKDWKDVDSRRU
prognosis, and the test is usually performed by John. He asks a fellow employee to analyze
the sample for him and not divulge the results. This ethical issue concerns:
a. confidentiality of patient genetic and medical information.
b. a conflict of interest.
c. resource allocation.
