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Cman 272 Exam 1 Pharmacology Antidepressants Neurotransmitters

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CMAN 272 EXAM 1 PHARMACOLOGY ANTIDEPRESSANTS NEUROTRANSMITTERS

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CMAN 272 EXAM 1 PHARMACOLOGY
ANTIDEPRESSANTS/NEUROTRANSMITTERS
What is the MOA of Nefazodone? - Answer -Weak Serotonin and norepinephrine
Inhibition (agonist)
Primarily: 5HT2 Antagonist/Alpha1 and H1 antagonist

What are the nursing implications for Nefazodone? - Answer -** not for those with pre
existing liver damage or disease!
- drug can be hepatotoxic
- check liver function enzymes
- teach about orthostatic hypotension ( get up slowly )
- monitor weight gain and BP (specifically hypotension)

What are the indications for Nefazodone? - Answer -Depression ONLY

What are the side effects of Nefazodone? - Answer -** think about alpha 1 antagonistic
effects
- hypotension & orthostatic hypotension
- dizziness
- hepatotoxicity
- paresthesias
- sedation

other:
- headache
- fatigue
- dry mouth
- weight gain
- constipation
- blurry vision
- nausea

Benefits to Nefazodone? - Answer -- possibly lower long term weight gain (compared to
SSRI's or TCA's)
- lower risk of sexual side effects of SSRI's

What class of drugs is Nefazodone in? - Answer -Atypical anti depressants
(SARI's) Serotonin antagonist and reuptake inhibitor

What is the MOA of Trazodone? - Answer -inhibits serotonin reuptake in synapse
5-HT reuptake inhibitor and 5-HT2a/2c antagonist

What are the nursing implications of Trazodone? - Answer -** severe sedation
- this drug can combat antidepressant-induced insomnia

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