USMLE Step 1 Rapid Review Rapid Review facts for
USMLE Step 1 Updated 2025/2026 100% VERIFIED
CORRECT NEW
Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) - Correct Answers
Budd-Chiari syndrome
Achilles tendon xanthoma - Correct Answers Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC - Correct Answers Waterhouse-Friderichsen syndrome
(meningococcemia)
Arachnodactyly, lens disloca$on, aor$c dissec$on, hyperflexible joints - Correct Answers
Marfan's (fibrillin defect)
Athlete with polycythemia - Correct Answers Erythropoie$n injec$on
Back pain, fever, night sweats, weight loss - Correct Answers Po/'s (TB to the vertebrae)
Bilateral hilar adenopathy, uvei$s - Correct Answers Sarcoid
Blue sclera - Correct Answers Osteogenesis imperfecta
Bluish line on gingiva - Correct Answers Burton's line - lead poisoning
Bone pain, bone enlargement, arthri$s, (also increased hat size, fracture, increased alk phos) -
Correct Answers Paget's
,Bounding pulses, diastolic hear murmur, head bobbing - Correct Answers Aor$c regurg
Café-au-lait spots, Lisch nodules - Correct Answers NF (1 = op$c glimoas and pheo, 2 =
acous$c Schwannomas)
Café-au-lait spots, polyosto$c fibrous dysplasia, precocious puberty - Correct Answers
McCune-Albright syndome (G protein problem)
Calf pseudohypertrophy - Correct Answers Duchenne's muscular dystrophy
Cherry-red spot on macula - Correct Answers Tay-Sachs, Niemann-Pick, central re$nal artery
occlusion
Chest pain, pericardial effusion/fric$on rub, persistent fever following MI - Correct Answers
Dressler's (autoimmune post-MI)
Child uses arms to stand up from squat - Correct Answers Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body - Correct Answers Slapped
cheek - B19
Chorea, demen$a, caudate degenera$on - Correct Answers Hun$ngton's
Chronic exercise intolerance with myalgia, fa$gue, painful cramps - Correct Answers McArdle's
(muscle phosphorylase deficiency)
Cold intolerance - Correct Answers Hypothyroidism
, Conjugate lateral gaze palsy, horizontal diplopia - Correct Answers Internuclear
ophthalmoplegia (MS or stroke)
Con$nuous machinery heart murmur - Correct Answers PDA
Cutaneous/dermal edema due to CT expansion - Correct Answers Myxedema
Dark purple skin / mouth nodules - Correct Answers Kaposi's sarcoma
Deep, labored breathing / hyperven$la$on - Correct Answers Kussmaul breathing, DKA
Derma$$s, demen$a, diarrhea - Correct Answers Pellagra (B3 / niacin deficiency)
Dilated cardiomyopathy, edema, polyneuropathy - Correct Answers Wet beriberi (B1 /
thiamine deficiency)
Dog or cat bite resul$ng in infec$on - Correct Answers Pasteurella multocida (local celluli$s)
Dry eyes, dry mouth, arthri$s - Correct Answers Sjogren's syndrome
Dysphagia (esophageal webs), glossi$s (smooth tongue), iron deficiency anemia - Correct
Answers Plummer-Vinson syndrome
Elas$c skin, hypermobility of joints - Correct Answers Ehler-Danlos (type III collagen)
Enlarged. hard leB supraclavicular node - Correct Answers VIrchow's node (abdominal met)
USMLE Step 1 Updated 2025/2026 100% VERIFIED
CORRECT NEW
Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) - Correct Answers
Budd-Chiari syndrome
Achilles tendon xanthoma - Correct Answers Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC - Correct Answers Waterhouse-Friderichsen syndrome
(meningococcemia)
Arachnodactyly, lens disloca$on, aor$c dissec$on, hyperflexible joints - Correct Answers
Marfan's (fibrillin defect)
Athlete with polycythemia - Correct Answers Erythropoie$n injec$on
Back pain, fever, night sweats, weight loss - Correct Answers Po/'s (TB to the vertebrae)
Bilateral hilar adenopathy, uvei$s - Correct Answers Sarcoid
Blue sclera - Correct Answers Osteogenesis imperfecta
Bluish line on gingiva - Correct Answers Burton's line - lead poisoning
Bone pain, bone enlargement, arthri$s, (also increased hat size, fracture, increased alk phos) -
Correct Answers Paget's
,Bounding pulses, diastolic hear murmur, head bobbing - Correct Answers Aor$c regurg
Café-au-lait spots, Lisch nodules - Correct Answers NF (1 = op$c glimoas and pheo, 2 =
acous$c Schwannomas)
Café-au-lait spots, polyosto$c fibrous dysplasia, precocious puberty - Correct Answers
McCune-Albright syndome (G protein problem)
Calf pseudohypertrophy - Correct Answers Duchenne's muscular dystrophy
Cherry-red spot on macula - Correct Answers Tay-Sachs, Niemann-Pick, central re$nal artery
occlusion
Chest pain, pericardial effusion/fric$on rub, persistent fever following MI - Correct Answers
Dressler's (autoimmune post-MI)
Child uses arms to stand up from squat - Correct Answers Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body - Correct Answers Slapped
cheek - B19
Chorea, demen$a, caudate degenera$on - Correct Answers Hun$ngton's
Chronic exercise intolerance with myalgia, fa$gue, painful cramps - Correct Answers McArdle's
(muscle phosphorylase deficiency)
Cold intolerance - Correct Answers Hypothyroidism
, Conjugate lateral gaze palsy, horizontal diplopia - Correct Answers Internuclear
ophthalmoplegia (MS or stroke)
Con$nuous machinery heart murmur - Correct Answers PDA
Cutaneous/dermal edema due to CT expansion - Correct Answers Myxedema
Dark purple skin / mouth nodules - Correct Answers Kaposi's sarcoma
Deep, labored breathing / hyperven$la$on - Correct Answers Kussmaul breathing, DKA
Derma$$s, demen$a, diarrhea - Correct Answers Pellagra (B3 / niacin deficiency)
Dilated cardiomyopathy, edema, polyneuropathy - Correct Answers Wet beriberi (B1 /
thiamine deficiency)
Dog or cat bite resul$ng in infec$on - Correct Answers Pasteurella multocida (local celluli$s)
Dry eyes, dry mouth, arthri$s - Correct Answers Sjogren's syndrome
Dysphagia (esophageal webs), glossi$s (smooth tongue), iron deficiency anemia - Correct
Answers Plummer-Vinson syndrome
Elas$c skin, hypermobility of joints - Correct Answers Ehler-Danlos (type III collagen)
Enlarged. hard leB supraclavicular node - Correct Answers VIrchow's node (abdominal met)
