Gms 6552 Lecture Exam 2 Actual 2025/2026 Questions And 100% Correct Answers

GMS 6552 LECTURE EXAM 2 ACTUAL 2025/2026 QUESTIONS AND 100% CORRECT ANSWERS Oncogene - Answer -A gene that causes or contributes to the development of cancer Hallmarks of Cancer - Answer -Sustaining proliferative signaling Evading growth suppressors Activating invasion and metastasis Enabling replicative immortality Inducing angiogenesis Resisting cell death In vivo oncogenic evidence - Answer -Cause cancer when activated in a transgenic animal Render nontumorigenic cells tumorigenic Knock down or knock out in tumorigenic cells renders the cells nontumorigenicNeed assistance in Online classes, Exams & Assignments? Reach out for Full Course Assistance, Plagiarism-free Essay Writing, Research Paper & Discussion Posts. Confidential & Secure! Email now at: Activation/overexpression of the oncogene is strongly correlated with human cancer In vitro oncogenic evidence - Answer -Causes anchorage-independent growth in soft agar (protection from anoikis) Causes focus formation (loss of contact inhibition) Renders cell growth factor independent Oncogenes in Cancer - Answer -Aberrant expression of proto-oncogenes that increases cell proliferation/survival First identified in cancer-causing viruses Typically a dominant mechanism Oncogene activation is usually limited to somatic tissue, but more cases of inherited oncogene mutations are being found Biochemical functions of oncogenes - Answer -G-proteins (Ras) Protein Kinases (Raf, Akt) Lipid Kinases (PI3-Kinase)