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COMLEX Level 1 Questions with Detailed
Verified Answers
MOA: Paxlitaxal
⼀Answer:- Microtubule inhibitor
Stabilizes polymerized microtubules. prevent completion of mitosis by
preventing breakdown of the mitotic spindle
MOA + Use: Oxandrolone
⼀Answer:- MOA: Anabolic-Androgenic steroid
Use: Treatment of severe burns
ADE: Testicular atrophy
MOA: Sirolimus
⼀Answer:- mTOR inhibitor
-binds FKBP to inhibit mTOR
inhibits proliferation of T cells in response to IL2
MOA of tacrolimus
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⼀Answer:- Calcineurin inhibitor via binding with intracellular FKBP-
12 protein which
impairs IL-2
use: transplant rejection
MOA: Danazol
⼀Answer:- Synthetic steroid
Decreases production of LH and FSH
What is the most common cause of death in patients with
Polycystic Kidney Disease?
⼀Answer:- Cardiac disease
Elevation of which hormone can confirm menopause in women of
appropriate age?
⼀Answer:- FSH
What are the positive immunohistochemical stains for
leiomyosarcoma?
⼀Answer:- Desmin
Vimentin
H-Caldesmon
Actin
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Which renal pathology is associated with Broad, waxy casts?
⼀Answer:- Advanced Chronic renal failure
What drug is commonly used for Neuropathic pain?
⼀Answer:- Amitriptyline (TCA)
ADE of note: strong muscarinic blocking properties = urinary retention
and tachycardia
Location of high risk HPV strain infections
⼀Answer:- basal layer of the squamous epithelium of the ectocervix
MOA of acyclovir
⼀Answer:- Competitively inhibits DNA polymerase, chain
termination occurs
tx for genital herpes
Describe histological appearance of leydig cell tumor
⼀Answer:- large polygonal cells with vacuolated cytoplasm and
Reinke Crystals (found in the interstitum of the testes) = rod shaped
intracytoplasmic crystal inclusions with rounded ends
What is the first line treatment for gonorrhea?
, Page | 4
⼀Answer:- Ceftriaxone
** remember to treat for this and chlamydia ( add azithromycin or
doxycycline)
Where do you see Anti--microsomal antibodies?
⼀Answer:- Hashimoto's thyroiditis
What are the signs and symptoms associated with Paget's disease
of the breast?
⼀Answer:- crusting, eczema like reaction, fissures around the areola
associated with an invasive DUCTAL carcinoma
MOA of tamoxifen?
⼀Answer:- Antagonist at breast
agonist at bone, uterus
ADE: increased risk thromboembolic events (esp with smoking) and
endometrial cancer
leiomyoma
COMLEX Level 1 Questions with Detailed
Verified Answers
MOA: Paxlitaxal
⼀Answer:- Microtubule inhibitor
Stabilizes polymerized microtubules. prevent completion of mitosis by
preventing breakdown of the mitotic spindle
MOA + Use: Oxandrolone
⼀Answer:- MOA: Anabolic-Androgenic steroid
Use: Treatment of severe burns
ADE: Testicular atrophy
MOA: Sirolimus
⼀Answer:- mTOR inhibitor
-binds FKBP to inhibit mTOR
inhibits proliferation of T cells in response to IL2
MOA of tacrolimus
, Page | 2
⼀Answer:- Calcineurin inhibitor via binding with intracellular FKBP-
12 protein which
impairs IL-2
use: transplant rejection
MOA: Danazol
⼀Answer:- Synthetic steroid
Decreases production of LH and FSH
What is the most common cause of death in patients with
Polycystic Kidney Disease?
⼀Answer:- Cardiac disease
Elevation of which hormone can confirm menopause in women of
appropriate age?
⼀Answer:- FSH
What are the positive immunohistochemical stains for
leiomyosarcoma?
⼀Answer:- Desmin
Vimentin
H-Caldesmon
Actin
, Page | 3
Which renal pathology is associated with Broad, waxy casts?
⼀Answer:- Advanced Chronic renal failure
What drug is commonly used for Neuropathic pain?
⼀Answer:- Amitriptyline (TCA)
ADE of note: strong muscarinic blocking properties = urinary retention
and tachycardia
Location of high risk HPV strain infections
⼀Answer:- basal layer of the squamous epithelium of the ectocervix
MOA of acyclovir
⼀Answer:- Competitively inhibits DNA polymerase, chain
termination occurs
tx for genital herpes
Describe histological appearance of leydig cell tumor
⼀Answer:- large polygonal cells with vacuolated cytoplasm and
Reinke Crystals (found in the interstitum of the testes) = rod shaped
intracytoplasmic crystal inclusions with rounded ends
What is the first line treatment for gonorrhea?
, Page | 4
⼀Answer:- Ceftriaxone
** remember to treat for this and chlamydia ( add azithromycin or
doxycycline)
Where do you see Anti--microsomal antibodies?
⼀Answer:- Hashimoto's thyroiditis
What are the signs and symptoms associated with Paget's disease
of the breast?
⼀Answer:- crusting, eczema like reaction, fissures around the areola
associated with an invasive DUCTAL carcinoma
MOA of tamoxifen?
⼀Answer:- Antagonist at breast
agonist at bone, uterus
ADE: increased risk thromboembolic events (esp with smoking) and
endometrial cancer
leiomyoma
