AAB MT Hematology Exam Questions and
Answers (Solved Papers)
What is hemoglobin composed of? - Correct Answers ✅4
heme, 4 iron, 4 globins
What disorder does a defect in heme synthesis lead to? -
Correct Answers ✅Porphyria
Porphyria - Correct Answers ✅Deficiency in the enzymes of
the porphyrin pathway leads to insufficient production of
heme. The principal problem in these deficiencies is the
accumulation of porphyrins, the heme precursors, which are
toxic to tissue in high concentrations.
What is methemoglobin? - Correct Answers
✅Methemoglobin is a form of hemoglobin that contains ferric
[Fe3+] iron and has a decreased ability to bind oxygen.
However, the ferric iron has an increased affinity for bound
oxygen. When methemoglobin concentration is elevated in
red blood cells, tissue hypoxia can occur.
What is the function of the enzyme methemoglobin-
cytochrome C reductase in a red blood cell? - Correct
Answers ✅To keep iron in the ferrous state
What product is formed when ferrous iron of hemoglobin is
oxidized to the ferric state? - Correct Answers
✅Methemoglobin
,AAB MT Hematology Exam Questions and
Answers (Solved Papers)
What is carboxyhemoglobin? - Correct Answers ✅A stable
complex of carbon monoxide and hemoglobin that forms in
RBCs when carbon monoxide is inhaled or produced in normal
metabolism. Large quantities of it hinder delivery of O2 to the
body. Tobacco smoking (through carbon monoxide inhalation)
raises the blood levels of COHb by a factor of several times
from its normal concentrations.
Which hemoglobin has a 200 times greater binding capacity
for the hemoglobin molecule than oxygen? - Correct
Answers ✅Carboxyhemoglobin
Which hemoglobin derivative causes irreversible changes in
RBCs? - Correct Answers ✅Sulfhemoglobin -- makes blood
incapable of carrying oxygen.
Which of the following hemoglobins is NOT normally present
in a normal adult? - Correct Answers ✅Hb-S
Which embryonic hemoglobin is normally found in newborns?
- Correct Answers ✅Hb-F
What is the most abundant hemoglobin in a newborn? -
Correct Answers ✅Hb-F
,AAB MT Hematology Exam Questions and
Answers (Solved Papers)
What is the molecular structure of Hemoglobin S? - Correct
Answers ✅Valine replaces glutamic acid in the 6th position
of the beta chain
Which of the following hemoglobins is insoluble under
lowered oxygen tension? - Correct Answers ✅Hb-S
What laboratory test is used to confirm the specific diagnosis
of sickle cell anemia? - Correct Answers ✅Hemoglobin
electrophoresis
In the solubility test for hemoglobin S, what is the reagent
responsible for the reduction of the hemoglobin molecule? -
Correct Answers ✅Sodium dithionite
In hemoglobin C, what replaces glutamic acid? - Correct
Answers ✅Lysine
Which red blood cell inclusion is characteristic of hemoglobin
C disease? - Correct Answers ✅Rod-shaped crystals
What is hemoglobin F composed of? - Correct Answers ✅2
alpha and 2 gamma chains
Which hemoglobin is resistant to alkali denaturation? -
Correct Answers ✅Hb-F
, AAB MT Hematology Exam Questions and
Answers (Solved Papers)
Which hemoglobins are differentiated by the Kleihauer-Betke
technique? - Correct Answers ✅Hb-A1 from Hb-F
What is the order of migration of hemoglobins, from fastest to
slowest, on cellulose acetate at pH 8.4? - Correct Answers
✅A1, F, S, C
Why is citrate agar used when abnormal hemoglobins are
identified on cellulose acetate at pH 8.6? - Correct Answers
✅It separates hemoglobin S from hemoglobin D
The cyanmethemoglobin method measures all hemoglobin
pigments EXCEPT which one? - Correct Answers
✅Sulfhemoglobin
What is the diluent used in the cyanmethemoglobin method
for the determination of hemoglobin? - Correct Answers
✅Drabkin's solution
What is the normal plasma hemoglobin concentration? -
Correct Answers ✅2-3 mg/dL
Which plasma protein binds free hemoglobin? - Correct
Answers ✅Haptoglobin
Answers (Solved Papers)
What is hemoglobin composed of? - Correct Answers ✅4
heme, 4 iron, 4 globins
What disorder does a defect in heme synthesis lead to? -
Correct Answers ✅Porphyria
Porphyria - Correct Answers ✅Deficiency in the enzymes of
the porphyrin pathway leads to insufficient production of
heme. The principal problem in these deficiencies is the
accumulation of porphyrins, the heme precursors, which are
toxic to tissue in high concentrations.
What is methemoglobin? - Correct Answers
✅Methemoglobin is a form of hemoglobin that contains ferric
[Fe3+] iron and has a decreased ability to bind oxygen.
However, the ferric iron has an increased affinity for bound
oxygen. When methemoglobin concentration is elevated in
red blood cells, tissue hypoxia can occur.
What is the function of the enzyme methemoglobin-
cytochrome C reductase in a red blood cell? - Correct
Answers ✅To keep iron in the ferrous state
What product is formed when ferrous iron of hemoglobin is
oxidized to the ferric state? - Correct Answers
✅Methemoglobin
,AAB MT Hematology Exam Questions and
Answers (Solved Papers)
What is carboxyhemoglobin? - Correct Answers ✅A stable
complex of carbon monoxide and hemoglobin that forms in
RBCs when carbon monoxide is inhaled or produced in normal
metabolism. Large quantities of it hinder delivery of O2 to the
body. Tobacco smoking (through carbon monoxide inhalation)
raises the blood levels of COHb by a factor of several times
from its normal concentrations.
Which hemoglobin has a 200 times greater binding capacity
for the hemoglobin molecule than oxygen? - Correct
Answers ✅Carboxyhemoglobin
Which hemoglobin derivative causes irreversible changes in
RBCs? - Correct Answers ✅Sulfhemoglobin -- makes blood
incapable of carrying oxygen.
Which of the following hemoglobins is NOT normally present
in a normal adult? - Correct Answers ✅Hb-S
Which embryonic hemoglobin is normally found in newborns?
- Correct Answers ✅Hb-F
What is the most abundant hemoglobin in a newborn? -
Correct Answers ✅Hb-F
,AAB MT Hematology Exam Questions and
Answers (Solved Papers)
What is the molecular structure of Hemoglobin S? - Correct
Answers ✅Valine replaces glutamic acid in the 6th position
of the beta chain
Which of the following hemoglobins is insoluble under
lowered oxygen tension? - Correct Answers ✅Hb-S
What laboratory test is used to confirm the specific diagnosis
of sickle cell anemia? - Correct Answers ✅Hemoglobin
electrophoresis
In the solubility test for hemoglobin S, what is the reagent
responsible for the reduction of the hemoglobin molecule? -
Correct Answers ✅Sodium dithionite
In hemoglobin C, what replaces glutamic acid? - Correct
Answers ✅Lysine
Which red blood cell inclusion is characteristic of hemoglobin
C disease? - Correct Answers ✅Rod-shaped crystals
What is hemoglobin F composed of? - Correct Answers ✅2
alpha and 2 gamma chains
Which hemoglobin is resistant to alkali denaturation? -
Correct Answers ✅Hb-F
, AAB MT Hematology Exam Questions and
Answers (Solved Papers)
Which hemoglobins are differentiated by the Kleihauer-Betke
technique? - Correct Answers ✅Hb-A1 from Hb-F
What is the order of migration of hemoglobins, from fastest to
slowest, on cellulose acetate at pH 8.4? - Correct Answers
✅A1, F, S, C
Why is citrate agar used when abnormal hemoglobins are
identified on cellulose acetate at pH 8.6? - Correct Answers
✅It separates hemoglobin S from hemoglobin D
The cyanmethemoglobin method measures all hemoglobin
pigments EXCEPT which one? - Correct Answers
✅Sulfhemoglobin
What is the diluent used in the cyanmethemoglobin method
for the determination of hemoglobin? - Correct Answers
✅Drabkin's solution
What is the normal plasma hemoglobin concentration? -
Correct Answers ✅2-3 mg/dL
Which plasma protein binds free hemoglobin? - Correct
Answers ✅Haptoglobin
