GMS 6552 Exam With verified questions and
answers latest updated
What is an example of a Transcription factors that plays a biochemical role in
oncogenes. - CORRECT ANSWER-Myc, Fos, Jun, E2F1, ....
What is an example of a Lipid Kinases that plays a biochemical role in oncogenes. -
CORRECT ANSWER-PI3-Kinase
What is an example of a Binding and inactivating apoptotic proteins that plays a
biochemical role in oncogenes. - CORRECT ANSWER-BCL2
What is an example of a Protein Kinase Regulatory Subunits that plays a
biochemical role in oncogenes. - CORRECT ANSWER-Cyclins A, E, and D
,What is an example of a Transcriptional coactivators that plays a biochemical role
in oncogenes. - CORRECT ANSWER-ß-Catenin, YAP, TAZ
Five Ways to Activate Oncogenes - CORRECT ANSWER-1. Mutation of genes to
make it overactive.
2. Amplification of a normal gene
3. Chromosomal Rearrangement
4. Promoter/enhancer insertion
5. Hypomethylation of oncogene
An oncogene is defined as - CORRECT ANSWER-a gene that causes or
contributes to the development of cancer
What are the two types of evidence for oncogenic behavior? - CORRECT
ANSWER-In vivo
In vitro
What are the 4 criteria for In vivo oncogenic behavior - CORRECT ANSWER-
Cause cancer when activated in a transgenic animal
Render nontumorigenic cells tumorigenic
Knock down or knock out in tumorigenic cells renders the cells nontumorigenic
Activation/overexpression of the oncogene is strongly correlated with human
cancer
, What are the 3 criteria for In vitro oncogenic behavior - CORRECT ANSWER-
Causes anchorage-independent growth in soft agar (protection from anoikis)
Causes focus formation (loss of contact inhibition)
Renders cells growth factor independent
What is an example of a GTPase that plays a biochemical role in oncogenes. -
CORRECT ANSWER-Ras
What is an example of a Protein Kinases that plays a biochemical role in
oncogenes. - CORRECT ANSWER-Raf, Akt, BCR-ABL, Cdk4, Src
What are some examples of Chromosome Rearrangement? (2) - CORRECT
ANSWER-Philadelphia chromosome. balanced reciprocal translocation t(9:22) in
myeloid cells. Fuses 5' end of BCR gene (chr.22) to the coding region of oncogene
ABL
Burkitt's lymphoma t(8;14) juxtaposes Ig heavy chain locus promoter/enhancer
region and MYC oncogene. Results in high levels of MYC transcription in B cells.
The protein is normal but overexpressed.
What therapy choices do we have to treat HER2 breast cancer? - CORRECT
ANSWER-Herceptin, Pertuzumab, and Lapatinib
If the philedelphia chromosome is present and we have a lessened amount of
BCR-ABL tyr kinases, how do we treat it? - CORRECT ANSWER-Gleevec
answers latest updated
What is an example of a Transcription factors that plays a biochemical role in
oncogenes. - CORRECT ANSWER-Myc, Fos, Jun, E2F1, ....
What is an example of a Lipid Kinases that plays a biochemical role in oncogenes. -
CORRECT ANSWER-PI3-Kinase
What is an example of a Binding and inactivating apoptotic proteins that plays a
biochemical role in oncogenes. - CORRECT ANSWER-BCL2
What is an example of a Protein Kinase Regulatory Subunits that plays a
biochemical role in oncogenes. - CORRECT ANSWER-Cyclins A, E, and D
,What is an example of a Transcriptional coactivators that plays a biochemical role
in oncogenes. - CORRECT ANSWER-ß-Catenin, YAP, TAZ
Five Ways to Activate Oncogenes - CORRECT ANSWER-1. Mutation of genes to
make it overactive.
2. Amplification of a normal gene
3. Chromosomal Rearrangement
4. Promoter/enhancer insertion
5. Hypomethylation of oncogene
An oncogene is defined as - CORRECT ANSWER-a gene that causes or
contributes to the development of cancer
What are the two types of evidence for oncogenic behavior? - CORRECT
ANSWER-In vivo
In vitro
What are the 4 criteria for In vivo oncogenic behavior - CORRECT ANSWER-
Cause cancer when activated in a transgenic animal
Render nontumorigenic cells tumorigenic
Knock down or knock out in tumorigenic cells renders the cells nontumorigenic
Activation/overexpression of the oncogene is strongly correlated with human
cancer
, What are the 3 criteria for In vitro oncogenic behavior - CORRECT ANSWER-
Causes anchorage-independent growth in soft agar (protection from anoikis)
Causes focus formation (loss of contact inhibition)
Renders cells growth factor independent
What is an example of a GTPase that plays a biochemical role in oncogenes. -
CORRECT ANSWER-Ras
What is an example of a Protein Kinases that plays a biochemical role in
oncogenes. - CORRECT ANSWER-Raf, Akt, BCR-ABL, Cdk4, Src
What are some examples of Chromosome Rearrangement? (2) - CORRECT
ANSWER-Philadelphia chromosome. balanced reciprocal translocation t(9:22) in
myeloid cells. Fuses 5' end of BCR gene (chr.22) to the coding region of oncogene
ABL
Burkitt's lymphoma t(8;14) juxtaposes Ig heavy chain locus promoter/enhancer
region and MYC oncogene. Results in high levels of MYC transcription in B cells.
The protein is normal but overexpressed.
What therapy choices do we have to treat HER2 breast cancer? - CORRECT
ANSWER-Herceptin, Pertuzumab, and Lapatinib
If the philedelphia chromosome is present and we have a lessened amount of
BCR-ABL tyr kinases, how do we treat it? - CORRECT ANSWER-Gleevec
