MSN 671 QUESTIONS AND ANSWERS
Presynaptic reuptake transporters are a major method of inactivation of which of the
following - Answer -serotonin and GABA
What is constitutive activity - Answer -signal transduction when no agonist or inverse
agonist is bound to the receptor
a partial agonist has what effect on neurotransmission - Answer -net agonism when
neurotransmission is deficient and net antagonism when neurotransmission is
excessive
Agonists cause ligand-gated ion channels to: - Answer -
positive and negative allosteric modulations - Answer -both are only possible in the
presence of a neurotransmitter
DA receptors can be categorized as D1-like (D1 and D5 receptors) and D2-like (D2, D3,
and D4 receptors). What differentiates the two group of receptors. - Answer -D1-like
receptors are excitatory and D2-like receptors are inhibitory
Symptoms of schizophrenia are hypothetically attributable to malfunctioning in the -
Answer -mesocortical and mesolimbic pathways
for which set of disorder is psychosis considered an associated feature rather than a
defining feature for diagnosis? - Answer -Bipolar mania, Parkinson's disease
The activation of N-methyl-d-aspartate (NMDA) receptors requires the presence of:
A. Glutamate only
. Glutamate and glycine
C. Glutamate, glycine, and magnesium
D. Glutamate and magnesium - Answer -glutamate and glycine
a leading hypothesis of psychosis is - Answer -hypo functioning NMDA receptors
dysfunction at NMDA-receptor containing synapses is hypothesized to lead to excessive
glutamate release in the ventral tegmental area. Downstream, this is hypothesized to
lead to what effects on dopamine (DA)? - Answer -excessive DA release in the NA and
reduced DA release in the PFC
the neurodevelopmental hypothesis of schizophrenia centers heavily around the idea
that aberrant competitive elimination occurs. Competitive elimination is a stage of
neurodevelopment in which - Answer -rarely used synapses are pruned, while
frequently used synapses are preserved
Presynaptic reuptake transporters are a major method of inactivation of which of the
following - Answer -serotonin and GABA
What is constitutive activity - Answer -signal transduction when no agonist or inverse
agonist is bound to the receptor
a partial agonist has what effect on neurotransmission - Answer -net agonism when
neurotransmission is deficient and net antagonism when neurotransmission is
excessive
Agonists cause ligand-gated ion channels to: - Answer -
positive and negative allosteric modulations - Answer -both are only possible in the
presence of a neurotransmitter
DA receptors can be categorized as D1-like (D1 and D5 receptors) and D2-like (D2, D3,
and D4 receptors). What differentiates the two group of receptors. - Answer -D1-like
receptors are excitatory and D2-like receptors are inhibitory
Symptoms of schizophrenia are hypothetically attributable to malfunctioning in the -
Answer -mesocortical and mesolimbic pathways
for which set of disorder is psychosis considered an associated feature rather than a
defining feature for diagnosis? - Answer -Bipolar mania, Parkinson's disease
The activation of N-methyl-d-aspartate (NMDA) receptors requires the presence of:
A. Glutamate only
. Glutamate and glycine
C. Glutamate, glycine, and magnesium
D. Glutamate and magnesium - Answer -glutamate and glycine
a leading hypothesis of psychosis is - Answer -hypo functioning NMDA receptors
dysfunction at NMDA-receptor containing synapses is hypothesized to lead to excessive
glutamate release in the ventral tegmental area. Downstream, this is hypothesized to
lead to what effects on dopamine (DA)? - Answer -excessive DA release in the NA and
reduced DA release in the PFC
the neurodevelopmental hypothesis of schizophrenia centers heavily around the idea
that aberrant competitive elimination occurs. Competitive elimination is a stage of
neurodevelopment in which - Answer -rarely used synapses are pruned, while
frequently used synapses are preserved
