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COMLEX Level 1 Questions and Verified
Answers
MOA: Paxlitaxal
Ans: Microtubule inhibitor
Stabilizes polymerized microtubules. prevent completion of mitosis by preventing
breakdown of the mitotic spindle
MOA + Use: Oxandrolone
Ans: MOA: Anabolic-Androgenic steroid
Use: Treatment of severe burns
ADE: Testicular atrophy
MOA: Sirolimus
Ans: mTOR inhibitor
-binds FKBP to inhibit mTOR
inhibits proliferation of T cells in response to IL2
MOA of tacrolimus
Ans: Calcineurin inhibitor via binding with intracellular FKBP-12 protein which
impairs IL-2
use: transplant rejection
MOA: Danazol
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Ans: Synthetic steroid
Decreases production of LH and FSH
What is the most common cause of death in patients with Polycystic Kidney Disease?
Ans: Cardiac disease
Elevation of which hormone can confirm menopause in women of appropriate age?
Ans: FSH
What are the positive immunohistochemical stains for leiomyosarcoma?
Ans: Desmin
Vimentin
H-Caldesmon
Actin
Which renal pathology is associated with Broad, waxy casts?
Ans: Advanced Chronic renal failure
What drug is commonly used for Neuropathic pain?
Ans: Amitriptyline (TCA)
ADE of note: strong muscarinic blocking properties = urinary retention and
tachycardia
Location of high risk HPV strain infections
Ans: basal layer of the squamous epithelium of the ectocervix
MOA of acyclovir
Ans: Competitively inhibits DNA polymerase, chain termination occurs
tx for genital herpes
Describe histological appearance of leydig cell tumor
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Ans: large polygonal cells with vacuolated cytoplasm and Reinke Crystals (found in
the interstitum of the testes) = rod shaped intracytoplasmic crystal inclusions with
rounded ends
What is the first line treatment for gonorrhea?
Ans: Ceftriaxone
** remember to treat for this and chlamydia ( add azithromycin or doxycycline)
Where do you see Anti--microsomal antibodies?
Ans: Hashimoto's thyroiditis
What are the signs and symptoms associated with Paget's disease of the breast?
Ans: crusting, eczema like reaction, fissures around the areola
associated with an invasive DUCTAL carcinoma
MOA of tamoxifen?
Ans: Antagonist at breast
agonist at bone, uterus
ADE: increased risk thromboembolic events (esp with smoking) and endometrial
cancer
leiomyoma
Ans: AKA FIBROIDS
benign tumor of smooth muscle commonly found in the uterus
If symptomatic: menorrhagia, dysmenorrhea, dyspaurenia. can cause pregnancy
loss
What is associated with lesions of the trochlear nerve?
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Ans: Lesions of the trochlear nerve (cranial nerve IV) result in dysfunction of the
superior oblique muscle and an inability to depress the eye, leading to diplopia
when the patient tries to look downward.
What results from a lesion to the Amygdala?
Describe location
Ans: Kluver-Bucy Syndrome
Location: medial temporal lobe anterior to the hippocampus near the lateral
ventricle
What results due to a lesion of the hippocampus?
Ans: Anterograde amnesia
Large choroid plexus papilloma filling the 3rd ventricle will impact which brain region?
Ans: Hypothalamus
Responsible for thermoregulation and feeding behavior
Describe Amaurosis Fugax
Ans: acute and painless onset of monocular visual loss with a normal funduscopic
examination in the background of atherosclerosis.
Cause: hypoperfusion of optic nerve, retina, or both
MOA: TPA
Ans: degradation of fibrin through conversion of plasminogen to plasmin
Describe: Orthostatic Syncope
COMLEX Level 1 Questions and Verified
Answers
MOA: Paxlitaxal
Ans: Microtubule inhibitor
Stabilizes polymerized microtubules. prevent completion of mitosis by preventing
breakdown of the mitotic spindle
MOA + Use: Oxandrolone
Ans: MOA: Anabolic-Androgenic steroid
Use: Treatment of severe burns
ADE: Testicular atrophy
MOA: Sirolimus
Ans: mTOR inhibitor
-binds FKBP to inhibit mTOR
inhibits proliferation of T cells in response to IL2
MOA of tacrolimus
Ans: Calcineurin inhibitor via binding with intracellular FKBP-12 protein which
impairs IL-2
use: transplant rejection
MOA: Danazol
, Page | 2
Ans: Synthetic steroid
Decreases production of LH and FSH
What is the most common cause of death in patients with Polycystic Kidney Disease?
Ans: Cardiac disease
Elevation of which hormone can confirm menopause in women of appropriate age?
Ans: FSH
What are the positive immunohistochemical stains for leiomyosarcoma?
Ans: Desmin
Vimentin
H-Caldesmon
Actin
Which renal pathology is associated with Broad, waxy casts?
Ans: Advanced Chronic renal failure
What drug is commonly used for Neuropathic pain?
Ans: Amitriptyline (TCA)
ADE of note: strong muscarinic blocking properties = urinary retention and
tachycardia
Location of high risk HPV strain infections
Ans: basal layer of the squamous epithelium of the ectocervix
MOA of acyclovir
Ans: Competitively inhibits DNA polymerase, chain termination occurs
tx for genital herpes
Describe histological appearance of leydig cell tumor
, Page | 3
Ans: large polygonal cells with vacuolated cytoplasm and Reinke Crystals (found in
the interstitum of the testes) = rod shaped intracytoplasmic crystal inclusions with
rounded ends
What is the first line treatment for gonorrhea?
Ans: Ceftriaxone
** remember to treat for this and chlamydia ( add azithromycin or doxycycline)
Where do you see Anti--microsomal antibodies?
Ans: Hashimoto's thyroiditis
What are the signs and symptoms associated with Paget's disease of the breast?
Ans: crusting, eczema like reaction, fissures around the areola
associated with an invasive DUCTAL carcinoma
MOA of tamoxifen?
Ans: Antagonist at breast
agonist at bone, uterus
ADE: increased risk thromboembolic events (esp with smoking) and endometrial
cancer
leiomyoma
Ans: AKA FIBROIDS
benign tumor of smooth muscle commonly found in the uterus
If symptomatic: menorrhagia, dysmenorrhea, dyspaurenia. can cause pregnancy
loss
What is associated with lesions of the trochlear nerve?
, Page | 4
Ans: Lesions of the trochlear nerve (cranial nerve IV) result in dysfunction of the
superior oblique muscle and an inability to depress the eye, leading to diplopia
when the patient tries to look downward.
What results from a lesion to the Amygdala?
Describe location
Ans: Kluver-Bucy Syndrome
Location: medial temporal lobe anterior to the hippocampus near the lateral
ventricle
What results due to a lesion of the hippocampus?
Ans: Anterograde amnesia
Large choroid plexus papilloma filling the 3rd ventricle will impact which brain region?
Ans: Hypothalamus
Responsible for thermoregulation and feeding behavior
Describe Amaurosis Fugax
Ans: acute and painless onset of monocular visual loss with a normal funduscopic
examination in the background of atherosclerosis.
Cause: hypoperfusion of optic nerve, retina, or both
MOA: TPA
Ans: degradation of fibrin through conversion of plasminogen to plasmin
Describe: Orthostatic Syncope
