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Exam (elaborations)

NR 507 – Immune System & Inflammation | Advanced Pathophysiology Review with Accurate Q&A | Exam preparation material

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This document provides a focused review of the immune system and inflammation content for NR 507, featuring clearly explained answers to exam-level questions. Topics include innate vs adaptive immunity, hypersensitivity reactions (Types I–IV), the inflammatory process, cytokines, histamine, mast cells, autoimmunity, HIV/AIDS pathology, T and B lymphocytes, and clinical applications of immune response. Ideal for advanced nursing students preparing for pathophysiology exams or understanding immune-related disease processes.

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NR507 Immune, Hematology, CV, Pulmonary,
Urinary questions with accurate answers
_________ A group of proteins that, when activated, can cause cell lysis
and inflammation
A. B-cells
B. T-cells
C. Autoantibodies
D. Immune complexes
E. Complement system Ans✓✓✓ E.
The complement system is a group of proteins that, when activated, can
cause cell lysis and inflammation.


_________ Bind to self-antigens, forming complexes that precipitate in
tissues
A. B-cells
B. T-cells
C. Autoantibodies
D. Immune complexes
E. Complement system Ans✓✓✓ C.
Autoantibodies, made by B cells, bind to self-antigens, forming immune
complexes that precipitate in tissues and cause inflammation.


_________ Modulate immune activity and may be involved in the
breakdown of self-tolerance, leading to autoimmune reactions

,A. B-cells
B. T-cells
C. Autoantibodies
D. Immune complexes
E. Complement system Ans✓✓✓ B.
T cells modulate the immune response. Due to a breakdown in "self"
versus "non-self" recognition, T cells mount an immune response to self-
antigens, producing cytokines and activating B cells.


_________ Precipitate in tissues, leading to inflammation and tissue
damage
A. B-cells
B. T-cells
C. Autoantibodies
D. Immune complexes
E. Complement system Ans✓✓✓ D.
Immune complexes precipitate in tissues, leading to inflammation and
tissue damage. They are made from autoantibodies that bind to self-
antigens.


_________ Produce autoantibodies
A. B-cells
B. T-cells
C. Autoantibodies

,D. Immune complexes
E. Complement system Ans✓✓✓ A.
B cells produce autoantibodies when activated by T cells that do not
recognize "self" cells and instead activate an immune response.


____________ are the primary effector cells and responsible for
initiating and mediating _____________ hypersensitivity.
Eosinophils, Neutrophils, Mast cells, or T-cells
Type 1, 2, 3, or 4 Ans✓✓✓ Mast cells are the primary effector cells and
responsible for initiating and mediating type 1 hypersensitivity reactions.


Characterized by the rapid release of proinflammatory mediators like
histamine, leukotrienes, and cytokines in response to allergen exposure,
mast cells are the primary effector cells responsible for initiating and
mediating type 1 hypersensitivity reactions.


____________ hypersensitivity reactions involve the formation of
_____________ that can deposit in tissues, leading to complement
activation, inflammation, and tissue destruction.
Type 1, 2, 3, or 4
IgE, IgM, IgG, immune complexes Ans✓✓✓ Type 3 hypersensitivity
reactions involve the formation of immune complexes that can deposit in
tissues, leading to complement activation, inflammation, and tissue
destruction.

, Type 3 hypersensitivity reactions involve the formation of immune
complexes that can deposit in tissues, leading to complement activation
and inflammation. This process can cause tissue damage and is
associated with systemic lupus erythematosus (SLE) and serum
sickness.
Type 1 reactions are mediated by IgE antibodies, and type 2 are
mediated by IgG or IgM antibodies. Type 4 reactions are activated by T-
helper cells.


13 yo patient diagnosed with sequestration crisis secondary to sickle cell
disease. Chief complaint: severe abd pain and weakness. Which of the
following findings is the best indicator of an improved outcome?
A. Pulse oximetry 98% on room air
B. Resolution of abdominal pain
C. Normal skin color
D. Hemoglobin level 12 g/dL Ans✓✓✓ B.
While all outcomes are important, the best indicator of improvement in
this scenario is resolution of abdominal pain. This directly addresses the
client's chief complaint, aligns with the goals of pain management, and
provides a tangible measure of the client's comfort and response to
treatment. Continuous monitoring of hemoglobin, pulse oximetry, and
skin color are essential for a comprehensive assessment.
An increase in hemoglobin suggests improved oxygen-carrying capacity
and may indicate a positive response to treatment. Stabilization or
improvement in pulse oximetry readings, specifically an increase to 95%
or above, is essential for assessing enhanced oxygen saturation.
Improved skin color, returning to a normal or healthier hue, reflects

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