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radiation therapy is a ... therapy for solid tumors - Answer- local
radiation vs. chemotherapy - Answer- radiation= local
chemo= systemic
high energy ionizing radiation used to target.. - Answer- tumor cells
3 ways to administer radiation therapyh
*= most common - Answer- 1. external beam **
2. implant therapy
3. systemic radiotherapy
External beam/ Teletherapy examples
*= most common machine used - Answer- 1. linear accelerator **
2. cyberknife
3. cobalt, orthovoltage machine
radiation therapy from a distance - Answer- teletherapy
short distance radiation therapy - Answer- bracytherapy
3 types of implant therapy - Answer- 1. short term
2. permanent implants
3. surface applicators
indications for radiotherapy - Answer- 1. companion animal tumrrs
2. large animal tumors
3. human
do we perform a lot of linear accelerator radiotherapy on horses? - Answer- no
sedation multiple times, multiple treatments
companion animal radiotherapy 2 forms of therapy - Answer- 1. definitive therapy:
curative intent
2. palliative therapy: pain relief
over ... of people with cancer are given some form of radiotherapy as part of their
treatment - Answer- half
radiation only works where... - Answer- you put it
- field is collimated much like a diagnostic radiograph
, do animals get radiation sickness when treated? - Answer- no, only local side effects
how radiation works
it is an ionizing radiation with high ... photons - Answer- energy
radiation used is 1000x kVp of X ray energy
... voltage - Answer- megavoltage
what is targeted with radiation therapy? - Answer- DNA
- damages the cells causing them to die when they attempt to undergo mitosis
radiation sensitivity is greatest at what part in the cell cycle?*** - Answer- G2/M
combining different modalities of radiotherapy can target... - Answer- different phases of
cell cycle
radiation damage
does radiation just target the tumor? - Answer- no, it will also target the surrounding
healthy tissue causing damage
when do we see radiation damage?* - Answer- when cells go through MITOSIS
each does of radiation is called a .. - Answer- fraction (fx)
unit of radiation - Answer- Gy (gray)
Linac
stands for.. - Answer- linear accelerator
RT or XRT stands for.. - Answer- radiation therapy
fractionation*
total dose (Gy) = ...x... - Answer- number of fractions x fraction size
fractionation can give a higher ... with smaller.... to avoid permanent damage - Answer-
higher total dose with smaller fraction size
tissue repairs itself between fractions
which heals better, normal tissue or tumor? - Answer- normal tissue> tumor
what type of normal tissue is MOST sensitive to the size of each fraction - Answer-
LATE responding normal tissue
fractionation protocols
10-20 fractions x 2.5-4.1 Gy= 48-60 Gy - Answer- conventional protocol