Radiation Therapy - Answer- Use of high energy-rays or other radiation particles to treat
malignant and some benign conditions
External Beam Radiation - Answer- electromagnetic radiation from machine i.e. linear
accelerator, photons, xray
Gamma rays - Answer- photons emitted from radioactive source such as colbolt-60
cesium-137 iridium-192
Brachytherapy - Answer- the use of radioactive materials in contact with or implanted
into the tissues to be treated
Hypo fractionization - Answer- shorter courses of treatment
Hyperfractionization - Answer- multiple daily fractions
Image guided RT (IGRT) - Answer- the use of image guidance to localize the target
both before and during treatment
Volumetric modulated arc therapy (VMAT) - Answer- treatment can be focused on the
tumor while protecting normal tissue in a faster period.
Image Guided Radiation Therapy (IGRT) - Answer- the use of image guidance to
localize the target both before and during treatment
Stereotactic Body Radiation Therapy (SBRT) - Answer- a highly effective local therapy
that requires accurate targeting, immobilization and tumor motion management to
deliver a large dose of RT in fewer fractions.
Five R's of radiobiology - repair, reassortment, repopulation, reoxygenation,
radiosensitivity - Answer- the rationale for fractionization of radiation
Repair - Answer- DNA repair lethal radiation damage; repair of normal cells.
Reassortment - Answer- Following a fraction of radiation, there is redistribution of cells
into a radiosensitive phase of the cell cycle
Repopulation - Answer- During radiation, tumor cell proliferation can occur.
Reoxygenation - Answer- Tumors consist of both oxygenated and hypoxic cells;
increases the sensitivity of tumor cells to RT