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2025/2026 ACNPC-AG Exam Review – 85 Clinical Questions with Accurate Answers | Cardio, Neuro, Infectious Disease, GI, MSK & More

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This comprehensive study guide includes 85 board-style questions with correct answers tailored for the Adult-Gerontology Acute Care Nurse Practitioner (ACNPC-AG) certification exam for the 2025/2026 cycle. Aligned with current AACN and ACNPC-AG exam standards, this resource covers a wide range of essential acute care topics including cardiovascular pathology (e.g., murmurs, valve disorders, aortic stenosis), neurology (e.g., hematomas, neuro assessments, dislocations), infectious disease (e.g., sepsis management, reportable STIs), gastrointestinal emergencies (e.g., toxic megacolon, hepatic risks), shock types, trauma care, and musculoskeletal diagnostics (e.g., Lachman, Apley, and other special tests). Clear, concise answer explanations support clinical reasoning development and test readiness, with fast recall tips for high-yield facts like Light’s criteria, metabolic derangements, dermatologic red flags (e.g., melanoma, basal cell carcinoma), and appropriate diagnostic pathways (e.g., bronchoscopy for foreign body, 3-sided dressing for GSW). Who this document is for: AGACNP students in MSN, DNP, or post-master’s programs preparing for AACN ACNPC-AG certification Acute care clinical nurse specialists seeking recertification support Nurse practitioner students enrolled in acute care, pharmacology, or diagnostic reasoning courses Advanced practice nursing faculty or preceptors using board review as instructional material Keywords: ACNPC AG review 2025, acute care nurse practitioner exam, adult-gerontology NP study guide, board-style clinical questions, AACN certification prep, murmurs and valve disease, GI complications, sepsis protocols, shock classification, Light's criteria, neuro trauma, melanoma diagnosis, MSK injury tests, certification vs licensure, metabolic alkalosis and acidosis

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ACNPC AG 2025/2026 Exam Questions
and Corresponding Answers with Surety
of 100% Pass Mark



Early sepsis tx with empiric abx - 🧠 ANSWER ✔✔Within 6 hours


The clock drawing test is most correlated with - 🧠 ANSWER ✔✔Driving

performance


hypertrophic cardiomyopathy - 🧠 ANSWER ✔✔Genetic mutation


Myotonic Muscular Dystrophy - 🧠 ANSWER ✔✔Most common adult form of MD


"Clasp knife" on rapid motion - 🧠 ANSWER ✔✔Spasticity


Bicuspid aortic valve - 🧠 ANSWER ✔✔A congenital abnormality


Most common valve lesion in elderly - 🧠 ANSWER ✔✔Aortic stenosis


Rheumatic fever related valve disease - 🧠 ANSWER ✔✔Mitral stenosis

, SD hematoma - 🧠 ANSWER ✔✔Venous cross bridging


epidural hematoma - 🧠 ANSWER ✔✔Loc, arterial


Lights criteria - 🧠 ANSWER ✔✔LdH greater than 2/3 upper limit, pl to serum ldh

>.6; pl to serum protein > 0.5


PEs can cause both - 🧠 ANSWER ✔✔Trans or exudative effusions


Murphy's sign - 🧠 ANSWER ✔✔cholecystitis; R subcostal pressure produces pain


Psoas sign - 🧠 ANSWER ✔✔appendicitis


Obturator sign - 🧠 ANSWER ✔✔appendicitis or pelvic abscess; 90 degree passive

hip rotation


Battle sign - 🧠 ANSWER ✔✔mastoid bruising; basilar skull fx


Zollinger-Ellison syndrome - 🧠 ANSWER ✔✔+ gastrin leads to ulcers from +

partial acid production


posterior hip dislocation - 🧠 ANSWER ✔✔90% of cases with internal rotation and

affected limb shortening


ant hip dislocation - 🧠 ANSWER ✔✔External rotation, limb shortening not

significant

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